ID A0A091GWG1_BUCRH Unreviewed; 3118 AA.
AC A0A091GWG1;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Huntingtin {ECO:0000313|EMBL:KFO87921.1};
GN ORFNames=N320_11098 {ECO:0000313|EMBL:KFO87921.1};
OS Buceros rhinoceros silvestris.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Bucerotiformes; Bucerotidae; Buceros.
OX NCBI_TaxID=175836 {ECO:0000313|EMBL:KFO87921.1, ECO:0000313|Proteomes:UP000054064};
RN [1] {ECO:0000313|EMBL:KFO87921.1, ECO:0000313|Proteomes:UP000054064}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N320 {ECO:0000313|EMBL:KFO87921.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May play a role in microtubule-mediated transport or vesicle
CC function. {ECO:0000256|ARBA:ARBA00002907}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the huntingtin family.
CC {ECO:0000256|ARBA:ARBA00007153}.
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DR EMBL; KL515677; KFO87921.1; -; Genomic_DNA.
DR Proteomes; UP000054064; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR048412; Htt_bridge.
DR InterPro; IPR048413; Htt_C-HEAT_rpt.
DR InterPro; IPR048411; Htt_N_HEAT_rpt-1.
DR InterPro; IPR000091; Huntingtin.
DR InterPro; IPR028426; Huntingtin_fam.
DR InterPro; IPR024613; Huntingtin_N_HEAT_rpt-2.
DR PANTHER; PTHR10170:SF10; HUNTINGTIN; 1.
DR PANTHER; PTHR10170; HUNTINGTON DISEASE PROTEIN; 1.
DR Pfam; PF20925; Htt_bridge; 1.
DR Pfam; PF20927; Htt_C-HEAT; 1.
DR Pfam; PF12372; Htt_N-HEAT; 1.
DR Pfam; PF20926; Htt_N-HEAT_1; 1.
DR PRINTS; PR00375; HUNTINGTIN.
DR SUPFAM; SSF48371; ARM repeat; 2.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000054064}.
FT REGION 453..474
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 502..564
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 610..653
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1143..1201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1843..1863
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2611..2634
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 453..467
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 513..564
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 610..625
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 626..651
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1186..1201
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1843..1861
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3118 AA; 345926 MW; D913708894B3CD3C CRC64;
MATMEKLMKA FESLRSFQQQ QGPAAIPEEP LQRPAGAWPL APTVHSDMDA NWIMMVDTIW
RVKKELSTTK KDRVNHCLTI CENIVAQSLR NSPEFQKLLG IAMELFLLCS EDAESDVRMV
ADECLNKVIK ALMDSNLPRL QLELYKEIKK NGASRSLRAA LWRFAELAHL VRPQKCRPYL
VNLLPCLTRI SKRPEESVQE TLAAAIPKIM AAFGNFANDN EIKVLLKAFI ANLKSSSPTI
RRTAAASAVS ICQHSRRTQY FYAWLLNVLL GLLVPVEDDH PTLLILGVLL TLRYLIPLLQ
QQVKDTSLKG SFGVTRKETE ISPSPEQLTQ VYELTLHYTQ HQDHNVVTGA LELLQQLFRT
PPPELLHALT SSGGIAQVSV SKDESAIRNR SGSIMELIAG GGSSCSPVLA RKHKGKILLG
EEEGLEDDAE TRSDVSAASF AASMKGEISS ELASSSGVST TGSVGSSAAD PAGHDIITEQ
PRSQHTLQSD SVDLTSCDLT STATEGEEDD VLSRSSSQIS AVQSDPTMDL NDGTQASSPI
SDSSQTTTEG PDSAVTPSDS SETVLEGAEG QYSGMQIGQL QDEEDETANI LQDDSSESFR
NSSIALQQPH LLKTMSHSRQ PSDSSVDRFT SKEDAADPGD HENKPSRVKG DIGHYTDGNS
APLVHCVRLL SASFLLTGEK GALVPDRDVR VSVKALAVSC VGAAVALHPE SFFSKLYKTP
LEAMGEEYEE QYVSDILNYI DHGDPQIRGA TAILCGTIVN SILIKSRFDV EKWLINVRSS
TGNLFSLVDC IPLLQKTLKD ESSVTCKLAC TAVRHCIMSL CSSSYSELGL QLIVDLLTLK
NNSYWLVRTE LLETLAEVDF RLVSFLEGKT ESLHRGIHHY TGVMLNNVVI CLLGDEDPRV
RHVAAASLLR LVPKLFYNCD QGQADPVVAV ARDQSSVYLK LLMHETQPPS HFAVSTITRT
YRGYNMLQSP TDVTMENNLS RVIAAISHAL TISTTRALTF GCCEALCLLS TTFPVCTWSV
GWHCGVSQPS SSDEAQKGCT IGMAGMVLSL LSSAWFPLDL SAHQDALVLT GNLLAASAPK
CLKNPWSAEE DSNQGAAKQE EPWPALADRT LVTLVEQLFS HLLKVINICA HVMDDVAPGP
AVKAALPSLT NPPSLSPIRR KGKERESVEQ ASVPMSPKKG GETSPAPRQT DATGPVPANK
SSSVGSFYHL PSYLKLYDVL KATHANYKVT LDLQNSNEKF GSFLRSALDV LSQILELATL
QDIGKCVEEI LGYLKSCFNR EPTMATVCVQ QLLKTLFGTN LASQYDGLSS NPNKAQGKAQ
RLGSSSLRPG LYHYCFMAPY THFTQALADA SLRNMVQAEQ EHDASGWFDV LQKVSTQLKT
SITSAAKHRA DKNAIHSHIR LFEPLVIKAL KQYTTTTSVQ LQRQVLDLLA QLVQLRVNYC
LLDSDQVFIG FVLKQFEYIE VGQFRESEAI IPNIFFFLVL LSYERYHSKQ IIGIPKIIHL
CDGIMASGRK AVTHAIPALQ PIVHDLFVLR GTNKADAGKE LETQKEVVVS MLLRLIQYHQ
VLEMFILVLQ QCHKENEDKW KRLSRQIADI ILPMLAKQQM HIDSHDALGV LNTLFEILAP
SSLRPVDMLL RSMFVTPKTM ASVSTVQLWI SGILAILRVL ISQSTEDIVL SRIQELSFSP
YLISCQAINR LRHGENNVSA PEDRIEVKQA KNLPEETFSR FLLQLVGILL EDIVTKQLKV
NMNEQQHTFY CQELGTLLMC LIHIFKSGMF RRITAAATRL FTGDGSDGSF YTLESLSELV
QSMIPTHPSL VLLWCQILLL VNYTNYSWWS EVHQTPKRHS LSTTKLLSPQ ISGSSGESDS
ESKRGMCNRE IVRRGALILF CDYVCQNLHD SEHLTWLIVN HVQDLINLSH EPPVQDFISA
VHRNSAASGL FIQAIQSRCE NLAAPTTLKK TLQCLEGIHL SQSGAVLTLY VDKLLCTPFR
VLARMVDTLA CRRVEMLLAA TLQNSITQLP VEELDRIQEY LQSSGLATRH QRLYSLLDRF
RLMVAPDTTS PSPLITSHPL DGEDQPALEN VILDKDWYVS LVRSQCYIKS DSALLEGAEL
VNRIPQSDLN SFMTSKEFNL SLLAPCISLG MNEISRDQKS SFFETARRVT LDHVSTTVQN
LPANHQVFQP LLPAEPSAYW KKLSDIFGDE VMYQSMMTLC RALAQYLLLL SKLPAGLRVP
PDKEDDILKF VVTSVEALSW HLMHDQIPLS VDLQAALDCC CLTLQQPTLW NLLASAANVT
YACSLINCIR FIIEAVAVEP GNQLLSPERK KNTLKCLSEG EVDSNTQTTK HITAACEMVA
EMVECLQTVL ALGHKRNSSI PAFLTPVLKN IIISLARLPL VNSYTRVPPL VWKLGWSPKP
AGDFGTVFPE IPVEFLQEKE IFKEFIYRIN TLGWISRTQF EETWATLLGV LVTQPIVMDQ
EENQQEEDTE RTQINVLAVQ AITSLVLSAM TIPVAGNPAV SCLEQQPRNK ALKALDTRFG
RKLSVIRGIV EQEIQAMVSK RDNIATHHLY QAWDPVPSLS PATTGALISH EKLLLQINTE
REIGDMDYKL GQVSIHSIWL GNNITPLREE EWGEDEEDEN DIPAPSSPPT SPINTRKHRA
GVDIHSCSQF LLELYSQWIL PSNPSKRTPV ILISEVVRSL LAVSDLFTER NQFEMMYTTL
TELRKVHPSE DEILVQYLIP ATCKAAAVLG MDKAVAEPVS RLLESTLRST HMPSRIGALH
GILYILECDL LDETAKQLIP IISEYLLSNL RGVAHCVNVH NQQHILVMCA AAFYLIENYP
LDVGPEFSAG IIQMCGVMVS GSDESTPSII YHCVLRGLER LLLSEQLSRL DSESLVKLSV
DRVNVQSPHR AMAALGLMLT CMYTGKEKIS PSRTSDANPA APDSESVIVA MERVSVLFDR
IRKGFPFEAR VVARILPQFL DDFFPPQDVM NKVIGEFLSN QQPYPQFMAA VVYKVFQTLH
STGQSSMVRD WVMLSLSNFT QRTPVAMAMW SLSCFFVSAS TSQWISAILP HIISRMGKSE
QVDVNIFCLV AIDFYRHQID EELDRRAFQS VFEVVASPGT PYHRLLTCLQ NVHKVTAC
//
