ID A0A091H6E9_9AVES Unreviewed; 770 AA.
AC A0A091H6E9;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Semaphorin-3A {ECO:0000313|EMBL:KFO81832.1};
DE Flags: Fragment;
GN ORFNames=N303_03582 {ECO:0000313|EMBL:KFO81832.1};
OS Cuculus canorus (common cuckoo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Cuculiformes; Cuculidae; Cuculus.
OX NCBI_TaxID=55661 {ECO:0000313|EMBL:KFO81832.1, ECO:0000313|Proteomes:UP000053760};
RN [1] {ECO:0000313|EMBL:KFO81832.1, ECO:0000313|Proteomes:UP000053760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N303 {ECO:0000313|EMBL:KFO81832.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the semaphorin family.
CC {ECO:0000256|ARBA:ARBA00009492}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KL448279; KFO81832.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091H6E9; -.
DR STRING; 55661.A0A091H6E9; -.
DR Proteomes; UP000053760; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0030215; F:semaphorin receptor binding; IEA:InterPro.
DR CDD; cd05871; Ig_Sema3; 1.
DR CDD; cd11249; Sema_3A; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR041416; IL-1RAcP-like_ig.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR042820; Sema3A_sema.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR027231; Semaphorin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR11036; SEMAPHORIN; 1.
DR PANTHER; PTHR11036:SF23; SEMAPHORIN-3A; 1.
DR Pfam; PF18452; Ig_6; 1.
DR Pfam; PF01403; Sema; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00423; PSI; 1.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000053760};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..770
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001874294"
FT DOMAIN 29..512
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT DOMAIN 574..663
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 728..770
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 747..770
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFO81832.1"
FT NON_TER 770
FT /evidence="ECO:0000313|EMBL:KFO81832.1"
SQ SEQUENCE 770 AA; 88646 MW; 091FBA0E0CC7B416 CRC64;
WLRGIALLSL GVLLAGRVNC QHVKNNVPRL KLSYKEMLES NNIINFNGLA NSSSYHTFLL
DEERSRLYVG AKDHIFSFNL VNIKEYQKIV WPVSHSRRDE CKWAGKDILR ECANFIKVLK
AYNQTHLYAC GTGAFHPVCA YIEVGSHPED NIFRMEDSHF ENGRGKSPYD PKLLTASLLV
DGELYSGTAA DFMGRDFAIF RTLGHHHPIR TEQHDSRWLN DPRFISAHLI PESDNPEDDK
IYFFFRENAI DGEHTGKATH ARIGQICKND FGGHRSLVNK WTTFLKARLI CSVPGPNGID
THFDELQDVF LMNSKDPKNP IVYGVFTTSS NIFKGSAVCM YSMTDVRRVF LGPYAHRDGP
NYQWVPYQGR VPYPRPGTCP SKTFGGFDST KDLPDEVITF ARSHPAMYNP VFPINNRPIM
IKTDVDYQFT QIVVDRVDAE DGQYDVMFIG TDVGTVLKVV SIPKETWHEL EEVLLEEITV
FREPTVISAM KISTKQQQLY IGSATGVSQL PLHRCDVYGK ACAECCLARD PYCAWDGSSC
SRYFPTAKRR TRRQDIRNGD PLTHCSDLQH HDNPSGQTLE EKIIYGVENS STFLECSPKS
QRAVVYWQFQ KQNDDRKEEI KVDDHMIRTE QGLLLRSLQR RDSGIYFCHA VEHGFMQTLL
KVTLEVIDTD HLEELLHKEE DGDASKTKDA TNSMTPSQKI WYRDFMQLIN HPNLNTMDEF
CEQVWKRDRK QRRQRPANTQ VNTNKWKHLQ ENKKGRNRRT HEFERAPRSV
//
