ID A0A091HAH3_BUCRH Unreviewed; 1481 AA.
AC A0A091HAH3;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
DE Flags: Fragment;
GN ORFNames=N320_05002 {ECO:0000313|EMBL:KFO91817.1};
OS Buceros rhinoceros silvestris.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Bucerotiformes; Bucerotidae; Buceros.
OX NCBI_TaxID=175836 {ECO:0000313|EMBL:KFO91817.1, ECO:0000313|Proteomes:UP000054064};
RN [1] {ECO:0000313|EMBL:KFO91817.1, ECO:0000313|Proteomes:UP000054064}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N320 {ECO:0000313|EMBL:KFO91817.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
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DR EMBL; KL527882; KFO91817.1; -; Genomic_DNA.
DR Proteomes; UP000054064; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 8.
DR CDD; cd05739; IgI_3_RPTP_IIa_LAR_like; 1.
DR CDD; cd14625; R-PTPc-S-1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 9.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF8; PROTEIN TYROSINE PHOSPHATASE RECEPTOR TYPE S; 1.
DR Pfam; PF00041; fn3; 7.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00014; FNTYPEIII.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 8.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 5.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50853; FN3; 8.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Receptor {ECO:0000313|EMBL:KFO91817.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054064};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1039..1062
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 6..88
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 95..185
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 190..284
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 288..377
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 382..479
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 484..583
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 584..677
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 682..778
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 782..876
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1129..1384
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1304..1375
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1416..1481
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFO91817.1"
FT NON_TER 1481
FT /evidence="ECO:0000313|EMBL:KFO91817.1"
SQ SEQUENCE 1481 AA; 165337 MW; 493CE12855B8F5A4 CRC64;
VRRVAPRFSI LPVSHEIMPG GNVNITCVAV GSPMPYVKWM QGAEDLTPED DMPVGRNVLE
LTDVKDSANY TCVAMSSLGV IEAVAQITVK SLPKAPGTPV VTETTATSIT ITWDSGNPDP
VSYYVIEYKS KSQDGPYQIK EDITTTRYSI GGLSPNSEYE IWVSAVNSIG QGPPSESVVT
RTGEQAPASA PRNVQGRMLS STTMIIQWEE PVEPNGQIRG YRVYYTMEPD QPVSNWQKHN
VDDSLLTTVG SLLEDETYTV RVLAFTSVGD GPLSDPIQVK TQQGVPGQPM NFRAEAKTET
SIVLSWSAPR QEIIVKYELL YKEGDHGREV QKNFEPTTSF TLEGLKPNTE YVFRLAARSA
LGLGAFTPEV RERTLQSKPS APPQDVKCVS TRSTAILVSW RPPPVESQNG ILAGYSVYYR
ALDSEDTELK EVNDIPPTTS QILLESLEKW TEYRITVVAH TEVGPGPESS PVIVRTDEDV
PSAPPRKVEV EVLNSTAIQV FWRSPVQNRQ HGQIRGYQVH YVRMENGEAR GLPQIKDIML
ADAQEMVIAG LQPETAYSIT VAAYTMKGDG ARSKPKVVTT KGAVPGKPIL SVHQTEENTL
LVKWEPPLDA EGQVMGYRLQ FGRKDVVPLA TLEFSATEDK YTAPSIHKGA TYVFKLAVKS
RAGFGEEAVQ ELTTPEDIPK GYPQILEASN ITAMSVQFGW LPPVLAERNG AIVKYTVAYW
EAGSPGNPLE KDLPPSPENS YTLNGLKPNT AYDVKIRAHT SKGPGPYSPT VQYRTFQLDQ
VLPKNFKVKM VTKTSVLLSW EFPENYNSPT PYKASGMAAS ELCIQYNGLN VDVDGRTTKK
LITNLRPHTF YNFVLMNRGN SMGGLQQNVA AWTAADMLSK KPEVTHKPDA DGNVVVILPD
VKSSVPVQAF YIVVVPLRKS RGGQFLNPLG SPEEMDLEEL VQDIARLRRR SLRHSRQLDF
PKPYIAARFR FLPSHFILGD MKHYDNFENR ALEPGQKYVV FILAVLQEPE ATFAASPFSD
PIQLDNPDPQ PIIDGEEGLI WVIGPVLAVV FIICIVIAIL LYKNKRKDSE PRTKCLLNNA
EITPHHPKDP VEMRRINFQT PGMLSHPPIP VSELAEHTEH LKANDNLKLS QEYESIDPGQ
QFTWEHSNLE VNKPKNRYAN VIAYDHSRVI LLPIEGIVGS DYINANYIDG YRKQNAYIAT
QGPLPETFGD FWRMVWEQRS ATIVMMTKLE EKSRIKCDQY WPGRGTDTYG MIQVTLLDTI
ELATFCVRTF SLHKNGSSEK REVRQFQFTA WPDHGVPEYP TPFLAFLRRV KTCNPPDAGP
IVVHCSAGVG RTGCFIVIDA MLERIKHEKT VDIYGHVTLM RSQRNYMVQT EDQYSFIHGA
LLEADACGNT QVPARNLYTY IQKLAQIEVG EHVTGMELEF KRLANSKAHT SRFISANLPC
NKFKNRLVNI MPYETTRVCL QPIRGVEGSD YINASFIDGY R
//
