ID A0A091HCY8_BUCRH Unreviewed; 4040 AA.
AC A0A091HCY8;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Dynein heavy chain 3, axonemal {ECO:0000313|EMBL:KFO92540.1};
DE Flags: Fragment;
GN ORFNames=N320_01609 {ECO:0000313|EMBL:KFO92540.1};
OS Buceros rhinoceros silvestris.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Bucerotiformes; Bucerotidae; Buceros.
OX NCBI_TaxID=175836 {ECO:0000313|EMBL:KFO92540.1, ECO:0000313|Proteomes:UP000054064};
RN [1] {ECO:0000313|EMBL:KFO92540.1, ECO:0000313|Proteomes:UP000054064}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N320 {ECO:0000313|EMBL:KFO92540.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; KL530192; KFO92540.1; -; Genomic_DNA.
DR Proteomes; UP000054064; Unassembled WGS sequence.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF1; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000054064}.
FT DOMAIN 1348..1487
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 1990..2137
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 732..780
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2843..2894
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFO92540.1"
FT NON_TER 4040
FT /evidence="ECO:0000313|EMBL:KFO92540.1"
SQ SEQUENCE 4040 AA; 462364 MW; 1B45B08A4EC2D0CC CRC64;
QTDSVYNVSN AKRLPELPPL PASASAAPSE LYQLVLKNSC YPPLMQQASQ TLAAPFKEQS
YYRSPSDSIA NNYTLTARDL KLKDVHKLKP SSMTGPSLAS KEFDPSRKKL KLTQGSQWTS
DRYTPPLNSL VERAPAHMRE LYVKTYTDNQ PLTPEEQFVI MHLHEKEISK QETPPSRNDI
ERYCYYIYNG VQEDMLAPQD EEMINGILKH VPTHVLSNPD LENLLASLKE EIKADYYITL
RKAIVDYILM DPAEKERLFI GSTPRPFPWR VVRAPVPWHS SYEEVKRWNE RNLFTVNPLM
PTLQQLWLSQ YSHLRFVRTE EMLCGGLPLL PSEFEEIIRR HCEEARDILQ NKWIPTCASI
FLDEKRKWLH FAPENDCDSS QQVESYFRSV AALMSLQLRE MVVNSLEDLL AFFMIHKDGN
DFTEPYREMQ FFLPQILTVK LSVEEPKIVF EPPLKECWDL ISRCFREILH SAEELPKVLD
KLYLHAKYSM NKPVCDIGKR LLFPELKRGD LTLRTVKPDE SLFSEYVNKV EKIFGSNIVG
PQKYLNVYSK YSYLLNNAQQ DVTDFLKEGH SLEALREKID SLTKLKREIA SMHVTVPLAM
FCLDALHLNE ELCSRTQNLK DRLIEFEVME NRELNNRICN EYMLMAKRMS EEPLSTEEIV
EFDTYLKKCS EVTVFELRQE VAKAAHRLKF LVDYADLSFF HWPVQIERIV ENSRNLLCDR
RNQAEMALLE RCSQFEETLE GYNKEVESYK KRDVMTIEEM KNNAEKFKEL NKNLDDALKE
FEFPLLQSII ANKQPFEQLW VTAYDFHTKS EEWMNGSLLK LNADEITEEV GNMWKIMYKL
SKSFPDLAGP RRLAENMKYK LDKFKQHLPV LSIACNRGMK ERHWKQISEI VGCEISPDET
TTLKDILDFG LTKYIDELEP IGASASKEYS LEKSIEKMKS EWGNMHLNLV KYRDTDTSIL
SAVDDIQLLL DDHIVKTQTI SGSPFVKPIE AECSAWEHKL RLMQDILDSW LKCQATWLYL
EPIFSSEDIV AQMPEEGRKF RVVDSHWKDI MAQVVKDTKV LVATEQPMML DRLQEANTLL
EEIQKGLNTY LEKKRLFFPR FFFLSNDELL EILSETKDPL RVQPHLKKCF EGIAKLEFTE
DLEIVGMISS EKEIVPFVDK IYPANAKGMV EKWLLQVEEM MLASVKQVLQ DGMREYIKVP
RKTWVLQWPG QVVICVSSIY WTEEVSVAIR KGTLPDFLEK SNLQIADIVE LVRGKLSSGA
RLTLGALIVI DVHARDVVAK LVEDKITDLN DFQWISQLRY YWEEKDVMVR MITTEAKYGY
EYLGNSLRLV ITPLTDRCYR TLMGALRLNL GGAPEGPAGT GKTETTKDLA KALAKQCVVF
NCSDGLDYKA MGKFFKGLAQ SGAWSCFDEF NRIEVEVLSV VAQQILSIQQ AIIRKLKTFI
FEGTEISLNP TCAVFITMNP GYAGRAELPD NLKALFRTVA MMVPDYALIG EISLYSMGFL
DSRSLAQKIV ATYRLCSEQL SSQHHYDYGM RAVKSVLTAA GNLKLKYPTE NESVLLLRAL
LDVNLAKFLA QDVPLFQGII SDLFPGVVLP TPDHDLFVQA LTENIKKMNL QPVPWFIGKI
IQIYEMMLVR HGFMIVGDAL SGKTSAYKVL AGALGDLCAA KSMDEFAVEY KIINPKAITM
GQLYGSFDPV SHEWTDGVLA NAFREQASSS TDDRKWIIFD GPVDAVWIEN MNTALDDNKK
LCLMSGEIIQ MNSKMNLIFE PADLEEASPA TVSRCGMIYM DPQQLGWEPL KDSYLNTLPP
ELQEEHRKLV SDMFMWLVQP CLDFIHLNCK AIVQTSPTHL SYSLMKLFAC LLDEIKQSEE
EEKESVSSQH TILKLQGLFL FALVWTVGGI IDADSRKKFD LFYRNLLMGR NDENPRPESV
KLTRNSIFPE NGSVYDFYFY KHGSGQWKMW TEYITKEEQV IPPGAKVSEL IIPTMETARQ
MFFLKTYVGH NVPLLFVGPT GTGKSAITNN FLLQLPKEKY IPSFITFSAR TSANQTQDIV
MSKLDRRRKG LFGPPLGKKA IIFVDDLNMP AKEVYGAQPP IELLRQWIDH GHWYDKKDTS
KINIIDVLLV SAMSPPGGGR NDITGRFTRH LNILSIHSFD DDILTKIFTA VADWHFSKGF
EPVFLRLGKM MVQATMVIYK MAVDNFLPTP SKSHYVFNLR DFSRVIKGVL LCPHTHLQNE
DKLIRLWIHE VYRVFCDRLI DEEDKKIFFQ MVEETTSNTF RQSINKVLSH LSPTGKISDD
DIRSLFFGDY LKPDTIVKVY DEITDLKQLT AVMEHYLKEY NNISKAPMSL VMFKFAIEHI
SRICRVLKQD NGHLLLVGIG GSGRQSATKL ATYMNTFELF QIEITKSYGI SEWKEDVKRV
MLTAGVGNKN VSFLFCDNQI KDEAFVEDIN MLLNTGDVPN IFATDEKAEI VEKMQGAARM
ENEKIEATPL AMYNFFTERV KKNLHIVLAM SPIGDAFRNR LRMFPSLINC CTIDWFQTWP
TDALEMVATK FLEDVELEDD IRKEVVSMCK YFQESVRELS ISYYTTLRRH NYVTPTSYLE
LVLTFKTLLS SKRQEVEMMR TRYLMGLQKL DFASSQVAEM QKELTALQPE LIRTSAETDK
MMIQIEKETS EVDAKKELVS ADEKEANEAA AVAKAIKDEC EGDLAEAMPA LEAALAALDT
LKPSDISLVK SMQNPPGPVK LIMESICVMK GTKPERKPDP SGSGKMLEDY WGPSKKILGD
LKFLESLKMY DKDNIPPAIM KRIRERFIDH PDFQPAVIKN VSSACEGLCK WVRAMEVYDR
VAKVVAPKRE RLRTAEGLLE VQMQKLKTKQ AELKEVVDHL QALNDEFQNM NDRKRELENN
IELCSQKLVR AEQLISGLGG EKERWTEAAR LLGIRYIDLI GDVLLSSGTV AYLGAFTVDY
RLQCQKQWQV LCNEKNIPCS SDFSLSSTLG DPVKIRAWHI AGLPVDSFSV DNGIIVSNSR
RWALMIDPQR QANKWVKNME KANKLSVIKL SDTHYVRTLE NAIQLGTPVL LENIGEELDA
FIEPILLKLT FKQQGVEYMK LGENIIEYSR DFRFYITTCL RNPHYLPEVA VKVCLLNFMI
TPLGLQDQLL GIVAAEEKPE LEEKKNKLII ESAANKKQLK EIEDKILEVL SSSEGNILED
ETAVNILSSS KELSEEISEK QKISSITEMQ IDSTRMGYKP VAVHSAVVFF CISDLANIEP
MYQYSLIWFI NLYVQSIAKS ERSEDLEERI RNITEHFTIS IYNNVCRSLF EKDKVLFSFL
LTVGILKGKD QIDDEVWRFL LTGGVALDNP HPNPAPEWLS DKSWAELVRA SSLTNLQGLM
EHVRESSSKW KLIYDSVRPH EEAFPDAWST LMGLDRMVIL RCLRPDKIIP AVQQFIVENM
GRTFTEPPTF DLGRSYSDSN CCAPLIFVLS PGADPMAGLL KFAEDVGMGG TSIRTISLGQ
GQGPIAAKMI YQAITDGTWV VLQNCHLATS WMPALEKICE EVIVPENTND KFRLWLTSYP
SEKFPVSILQ NGVKMTNEPP KGVRVNLLRS YLNDPISDPV FFSGCQKPEM WQKLLFGLCF
FHAIVQERRN FGPLGWNIPY EFNESDLRIS MQQIQMFLNE YEETPFEALT YLTGECNYGG
RVTDDKDRRL LLSLLSIVYN KDIEQDKYML AAGSDYYVPP HGPYESYIEY IRSLPITTHP
EVFGLHENAD ITKDNQETNQ LFHGVLLTLP REAGGGGKSP QETVEELAWD ILSKLPSGFD
VEEVMKVYPV LYEESMNTVL RQELIRFNRL TEVVRSSLIN LGKAIKGQVL MSSELEDVFN
SMLLGKVPSM WAAKSYPSLK PLGSYVSDLL CRLAFFQDWI VRGPPTVFWL SGFFFTQSFL
TGVLQNYARK HTIPIDHIGF EFEVMKQEHT MEKMPEDGAY VRGLFLEGAR WNRESLVIGE
SLPKMLYDSL PIIWLKPGES SRFLHLNIYS CPVYKTSARR GVLSTTGHST NYVLSIELPS
DKPQKHWINR GVAALCQLDD
//
