ID A0A091I4B2_CALAN Unreviewed; 1679 AA.
AC A0A091I4B2;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Intersectin-1 {ECO:0000313|EMBL:KFP03057.1};
DE Flags: Fragment;
GN ORFNames=N300_07293 {ECO:0000313|EMBL:KFP03057.1};
OS Calypte anna (Anna's hummingbird) (Archilochus anna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Caprimulgimorphae; Apodiformes;
OC Trochilidae; Calypte.
OX NCBI_TaxID=9244 {ECO:0000313|EMBL:KFP03057.1, ECO:0000313|Proteomes:UP000054308};
RN [1] {ECO:0000313|EMBL:KFP03057.1, ECO:0000313|Proteomes:UP000054308}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N300 {ECO:0000313|EMBL:KFP03057.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; KL218200; KFP03057.1; -; Genomic_DNA.
DR STRING; 9244.A0A091I4B2; -.
DR Proteomes; UP000054308; Unassembled WGS sequence.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd08375; C2_Intersectin; 1.
DR CDD; cd00052; EH; 2.
DR CDD; cd13264; PH_ITSN; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd11987; SH3_Intersectin1_1; 1.
DR CDD; cd11989; SH3_Intersectin1_2; 1.
DR CDD; cd11991; SH3_Intersectin1_3; 1.
DR CDD; cd11993; SH3_Intersectin1_4; 1.
DR CDD; cd11995; SH3_Intersectin1_5; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 5.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR000261; EH_dom.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR032140; INTAP.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR46006:SF9; INTERSECTIN-2 ISOFORM X1; 1.
DR PANTHER; PTHR46006; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF12763; EF-hand_4; 2.
DR Pfam; PF16617; INTAP; 1.
DR Pfam; PF16652; PH_13; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00018; SH3_1; 3.
DR Pfam; PF07653; SH3_2; 1.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00239; C2; 1.
DR SMART; SM00054; EFh; 2.
DR SMART; SM00027; EH; 2.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 5.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF47473; EF-hand; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 5.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS50031; EH; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 5.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000054308};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT DOMAIN 12..100
FT /note="EH"
FT /evidence="ECO:0000259|PROSITE:PS50031"
FT DOMAIN 44..79
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 211..300
FT /note="EH"
FT /evidence="ECO:0000259|PROSITE:PS50031"
FT DOMAIN 244..279
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 704..765
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 871..929
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 960..1018
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1032..1096
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1113..1172
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1195..1381
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1420..1529
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1537..1653
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 595..665
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 791..826
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 321..475
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFP03057.1"
FT NON_TER 1679
FT /evidence="ECO:0000313|EMBL:KFP03057.1"
SQ SEQUENCE 1679 AA; 190675 MW; C793F4D241FF6E25 CRC64;
GNLDIWAITV EERAKHDQQF HSLKPTSGFI TGDQARNFFF QSGLPQPVLA QIWALADMNN
DGRMDQLEFS IAMKLIKLKL QGYQLPSALP PVMKQPPIAL PTAPGFGIGG IASMPSLTTV
PPVPMASIPV VGMSPPLVSS VPAAAVPPLA NGAPAVIQPL PGFAHPAPLP KSSSFSRSGP
GSQLNAKLQK AQSFDVASVP PVAEWAVPQS SRLKYRQLFN SHDKTMSGHL TGPQARTILM
QSSLPQTQLA TIWNLSDIDQ DGKLTAEEFI LAMHLIDVAM SGQPLPPVLP PEYIPPSFSG
SLILLCPMFS HMKVTFEDKK RENFERGNLE LEKRRQALLE QQRKEQERLA QLERAEQERK
ERERQEQERK RQLELEKQLE KQRELERQRE EERRKEIERR EAAKRELERQ RQLEWERNRR
QELLNQRNKE QEDIVVLKAK KKTLEFELEA LNDKKNQLEG KLQDIRCRLS TQRQEIESTN
KSRELRIAEI THLQQQLQES QQMLGRLIPE KQLLNDQLKQ VQQNSLHRDS LLTIKRALEA
KELARQQLRD QLDEVEKETR SKLQEIDIFN NQLKELREIH NKQQLQKQKN LEAERLKQKE
QEKKTDLEKQ KEAQRRTQER DKQRLDRVQP EEDLQWQKKI QEDEKQKREE ITKKKESEDK
GKQEMQEKLS KLFQPHQEAN KPAVQAPWSN AEKAPLTISA QEDVKIVYYR ALYPFESRSH
DEITIQPGDI VMVDESQTGE PGWLGGELKG KTGWFPANYA EKIPESEVPA SVKPAIEAAA
APKVSVHETT TSLGAPASTE STATANNWAD FSSTWPTNTS EKPETDNWDA WAAQPSLTVP
SAGQLRQRSA FTPATVTGSS PSPVLGQGEK VEGLQAQALY PWRAKKDNHL NFNKNDIITV
LEQQDMWWFG EVQGQKGWFP KSYVKLISGP IRKSTSMDSG SSESPASLKR VASPAAKATM
SGEEYIAMYT YESSEQGDLT FQQGDMILVT KKDGDWWTGT LGDKSGVFPS NYVRLKDSEA
PGAAGKTGSL GKKPEIAQVI ASYTATGPEQ LTLAPGQLIL IRKKNPGGWW EGELQARGKK
RQIGWFPANY VKLLSPGTSK TTPTELPKSA ALPSVCQVIG MYDYTAQNDD ELAFNKGQII
NVLNKEDPDW WKGEVNGQVG LFPSNYVKLT TDMDPSQQWC ADLHLLDMLT PTERKRQGYI
HELIVTEENY VNDLQLVTEI FQKPLMESEL LTEKEVAMIF VNWKELIMCN IKLLKALRVR
KKMSGEKMPV KMIGDILTAQ LPHMQPYIRF CSCQLNGAAL IQQKTDEVPE FKEFVKRLAM
DPRCKGMPLS SFLLKPMQRV TRYPLIIKNI IENTPENHPD HSHLKHALEK AEELCSQVNE
GVREKENSDR LEWIQAHVQC EGLSEQLVFN SVTNCLGPRK FLHSGKLYKA KSNKELYGFL
FNDFLLLTQI IKPLGSSGTD KVFSPKSNLQ YKMYKTPIFL NEVLVKLPTD PSGDEPIFHI
SHIDRVYTLR AESINERTAW VQKIKAASEL YIETEKKKRE KAYLVRSQRA TGIGRLMVNI
VEGIELKPCR SHGKSNPYCE VTMGSQCHIT KTIQDTLNPK WNSNCQFFIK DLEQDVLCIT
VFERDQFSPD DFLGRTEIRV ADIKKDQGSK GPVTKCLLLH EVPTGEIVVR LDLQLFDEP
//
