ID   A0A091I536_CALAN        Unreviewed;       826 AA.
AC   A0A091I536;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   RecName: Full=Villin-1 {ECO:0000256|ARBA:ARBA00017436};
GN   ORFNames=N300_03577 {ECO:0000313|EMBL:KFP03322.1};
OS   Calypte anna (Anna's hummingbird) (Archilochus anna).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Caprimulgimorphae; Apodiformes;
OC   Trochilidae; Calypte.
OX   NCBI_TaxID=9244 {ECO:0000313|EMBL:KFP03322.1, ECO:0000313|Proteomes:UP000054308};
RN   [1] {ECO:0000313|EMBL:KFP03322.1, ECO:0000313|Proteomes:UP000054308}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N300 {ECO:0000313|EMBL:KFP03322.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell projection, filopodium tip
CC       {ECO:0000256|ARBA:ARBA00004495}. Cell projection, lamellipodium
CC       {ECO:0000256|ARBA:ARBA00004510}. Cell projection, microvillus
CC       {ECO:0000256|ARBA:ARBA00004105}. Cell projection, ruffle
CC       {ECO:0000256|ARBA:ARBA00004466}.
CC   -!- SIMILARITY: Belongs to the villin/gelsolin family.
CC       {ECO:0000256|ARBA:ARBA00008418}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KL218243; KFP03322.1; -; Genomic_DNA.
DR   RefSeq; XP_008495205.1; XM_008496983.1.
DR   AlphaFoldDB; A0A091I536; -.
DR   STRING; 9244.A0A091I536; -.
DR   GeneID; 103531342; -.
DR   CTD; 7429; -.
DR   OrthoDB; 25995at2759; -.
DR   Proteomes; UP000054308; Unassembled WGS sequence.
DR   GO; GO:0032433; C:filopodium tip; IEA:UniProtKB-SubCell.
DR   GO; GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
DR   GO; GO:0005902; C:microvillus; IEA:UniProtKB-SubCell.
DR   GO; GO:0001726; C:ruffle; IEA:UniProtKB-SubCell.
DR   GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR   GO; GO:0051693; P:actin filament capping; IEA:UniProtKB-KW.
DR   GO; GO:0007010; P:cytoskeleton organization; IEA:InterPro.
DR   CDD; cd11290; gelsolin_S1_like; 1.
DR   CDD; cd11289; gelsolin_S2_like; 1.
DR   CDD; cd11292; gelsolin_S3_like; 1.
DR   CDD; cd11293; gelsolin_S4_like; 1.
DR   CDD; cd11288; gelsolin_S5_like; 1.
DR   CDD; cd11291; gelsolin_S6_like; 1.
DR   Gene3D; 3.40.20.10; Severin; 6.
DR   Gene3D; 1.10.950.10; Villin headpiece domain; 1.
DR   InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR   InterPro; IPR007123; Gelsolin-like_dom.
DR   InterPro; IPR036180; Gelsolin-like_dom_sf.
DR   InterPro; IPR007122; Villin/Gelsolin.
DR   InterPro; IPR003128; Villin_headpiece.
DR   InterPro; IPR036886; Villin_headpiece_dom_sf.
DR   PANTHER; PTHR11977; VILLIN; 1.
DR   PANTHER; PTHR11977:SF35; VILLIN-1; 1.
DR   Pfam; PF00626; Gelsolin; 5.
DR   Pfam; PF02209; VHP; 1.
DR   PRINTS; PR00597; GELSOLIN.
DR   SMART; SM00262; GEL; 6.
DR   SMART; SM00153; VHP; 1.
DR   SUPFAM; SSF55753; Actin depolymerizing proteins; 4.
DR   SUPFAM; SSF82754; C-terminal, gelsolin-like domain of Sec23/24; 2.
DR   SUPFAM; SSF47050; VHP, Villin headpiece domain; 1.
DR   PROSITE; PS51089; HP; 1.
PE   3: Inferred from homology;
KW   Actin capping {ECO:0000256|ARBA:ARBA00022467};
KW   Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054308}.
FT   DOMAIN          760..826
FT                   /note="HP"
FT                   /evidence="ECO:0000259|PROSITE:PS51089"
SQ   SEQUENCE   826 AA;  92794 MW;  AC9CA6A85077083A CRC64;
     MVELSSKVSR TLDKTKPGIQ IWRIESMEMV PVPTKSYGNF YEGDSYILLS TRKSGNSFSY
     DIHYWLGKDS SQDEQGAAAI YTTQMDDHLG TVAVQHREVQ GHESETFRAY FKQGLIYKKG
     GVASGMRHVE TNTYNVQRLL HVKGKKNVVA GEVEMSWKSF NRGDVFLLDL GQLIIQWNGP
     ESNRNERLRA MTLAKDIRDR ERGGRAKVGI VDGENEGASP GLMQVLTHVL GEKRDIKPAI
     PDDKVDENLK SSLKLYHVSN ASGNLVIQEV AIRPLTQDML LHEDCYILDQ GGLKIFVWKG
     KNANKEEKQQ AMSRALGFIK AKNYPASTSV ETENDGSESS VFRQLFQKWT VPNQTSGLGK
     THAVGKVAKV EQVKFDATTL YAKPQMAAQQ KMVDDGSGEV EVWRVENNEL VPVEKRWFGH
     FYGGDCYLVL YTYSVGPKVN RIIYLWQGRQ ATTDELTASA YQAVILDQKY NNEPVQVRVT
     MGKEPAHLMA IFKGKMVVYA GGTSRAGNTE PTPSIRLFHV HGTTEYNTKA FEVPVRASSL
     NSNDVFVLKT PSCCYLWYGK GCSGDEREMG KMVADIISKS EKIVIAEGQE TSEFWVALGG
     KSQYANNKRL QEENSSMSPR LFECSNKTGT FLATEIVDFT QDDLEENDVY LLDTWDQVFF
     WIGNGANKSE KEAAAVMVQE YLRNHPSGRD LDTPIIMVKQ GHEPPTFTGW FMAWDPLNWA
     DRKSYEVLKA ELGDESSLGE LTSALTSKQE VFTATTTLLP EKLETFPLDV LVNTAAEDLP
     RGVDPSRKEC HLSDRDFEAV FGMKRSAFGN LPLWKQQKLK KDKGLF
//