ID A0A091K2A3_COLST Unreviewed; 845 AA.
AC A0A091K2A3;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN ORFNames=N325_11587 {ECO:0000313|EMBL:KFP30338.1};
OS Colius striatus (Speckled mousebird).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Coliiformes; Coliidae; Colius.
OX NCBI_TaxID=57412 {ECO:0000313|EMBL:KFP30338.1, ECO:0000313|Proteomes:UP000053615};
RN [1] {ECO:0000313|EMBL:KFP30338.1, ECO:0000313|Proteomes:UP000053615}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N325 {ECO:0000313|EMBL:KFP30338.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC multimeric enzyme that catalyzes the translocation of protons across
CC the membranes. Required for assembly and activity of the V-ATPase.
CC {ECO:0000256|RuleBase:RU361189}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KK539118; KFP30338.1; -; Genomic_DNA.
DR RefSeq; XP_010196720.1; XM_010198418.1.
DR AlphaFoldDB; A0A091K2A3; -.
DR GeneID; 104555143; -.
DR KEGG; csti:104555143; -.
DR CTD; 50617; -.
DR OrthoDB; 1967517at2759; -.
DR Proteomes; UP000053615; Unassembled WGS sequence.
DR GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR InterPro; IPR002490; V-ATPase_116kDa_su.
DR InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR PANTHER; PTHR11629:SF26; V-TYPE PROTON ATPASE 116 KDA SUBUNIT A 4; 1.
DR PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR Pfam; PF01496; V_ATPase_I; 1.
DR PIRSF; PIRSF001293; ATP6V0A1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW ECO:0000256|RuleBase:RU361189};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361189};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW Reference proteome {ECO:0000313|Proteomes:UP000053615};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361189};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361189};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT TRANSMEM 403..427
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 447..466
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 545..566
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 572..596
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 644..662
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 777..801
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT REGION 681..713
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 51..120
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 698..713
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 845 AA; 96778 MW; FE6D1ECBC32514C5 CRC64;
MASFFRSEEM SLMQLFLQVE AAYCCVSELG ELGLVQFRDL NANVNSFQRK FVNEVRRCES
LERILRFLEN EMEDNVEIVK LEKYPETPLP REMIDMEAVL EKLEAELLEA NRNQQTLKQN
FLELMELKHL LKKTQDFFEA ETNLTDDFFS EDTSGLLELR SNPAAAAAKL GFTAGVIRRE
RIIPFERLLW RACRGNIYLR YTEMDTPLED PVTREEVKKN VFIIFHQGEQ LKQKIKKICD
GFRATVYPCP ESAAERREML DGVNTRIEDL NTVMTQTESH RQRLLHEAAA NLWSWGIKVK
KIKAIYHILN CCNIDVTQQC VIAEIWFPVA DAGRIKKALH QGMERSGSAI APILTAIHTR
MAPPTFNRTN KFTAGFQNIV DAYGVGNYRE INPAPYTIIT FPFLFAVMFG DCGHGAVMLG
FALWMVMNEK SLLAQKSNNE IWNTFFSGRY LILLMGIFSM YTGFIYNDCF SKSFNIFGSS
WHVIAMFKNN SWNNSVLMEN TQLQLDPAVP GVYSGNPYPF GIDPIWNIAS NKLTFLNSYK
MKMSVVLGIV HMIFGVVLSL FNHIYFKKYI NIVLQFIPEM IFIISLFGYL VFMIIFKWCH
FDAHSSQSAP SILIHFINMF LFNYDDSSNA PLYLHQKEVQ SFLVIFALIA VPWMLLIKPF
ILRANYQKEQ RMIRSQAISA NPGGENEVDV PETNHSMKAS QGDHHGGGHG EHEDGGEEFN
FGDTFVHQAI HTIEYCLGCI SNTASYLRLW ALSLAHAQLS EVLWTMVMHN GLNNSSWIGL
IVIFIIFAAF AVLTVAILLV MEGLSAFLHA LRLHWVEFQN KFYMGAGYKF SPFSFKHIID
GTTEE
//
