ID A0A091KI49_9GRUI Unreviewed; 1878 AA.
AC A0A091KI49;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 44.
DE RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
DE Flags: Fragment;
GN ORFNames=N324_11911 {ECO:0000313|EMBL:KFP40279.1};
OS Chlamydotis macqueenii (Macqueen's bustard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Gruiformes; Otididae; Chlamydotis.
OX NCBI_TaxID=187382 {ECO:0000313|EMBL:KFP40279.1, ECO:0000313|Proteomes:UP000053330};
RN [1] {ECO:0000313|EMBL:KFP40279.1, ECO:0000313|Proteomes:UP000053330}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N324 {ECO:0000313|EMBL:KFP40279.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability of
CC excitable membranes. Assuming opened or closed conformations in
CC response to the voltage difference across the membrane, the protein
CC forms a sodium-selective channel through which Na(+) ions may pass in
CC accordance with their electrochemical gradient.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC Nav1.4/SCN4A subfamily. {ECO:0000256|ARBA:ARBA00038083}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR EMBL; KK746160; KFP40279.1; -; Genomic_DNA.
DR Proteomes; UP000053330; Unassembled WGS sequence.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.5.1190; iswi atpase; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR001696; Na_channel_asu.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF223; SODIUM CHANNEL PROTEIN TYPE 4 SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR Pfam; PF06512; Na_trans_assoc; 1.
DR PRINTS; PR00170; NACHANNEL.
DR SMART; SM00015; IQ; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
DR PROSITE; PS50096; IQ; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU361132};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361132};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361132};
KW Reference proteome {ECO:0000313|Proteomes:UP000053330};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU361132};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU361132};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361132};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361132};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU361132}.
FT TRANSMEM 117..142
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 187..206
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 218..239
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 245..265
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 403..430
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 715..733
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 745..768
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 780..804
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 825..853
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 915..938
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1150..1168
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1189..1211
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1217..1237
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1266..1292
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1390..1413
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1471..1489
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1501..1519
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1526..1551
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1588..1616
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1690..1715
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT DOMAIN 126..437
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 714..943
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 952..1144
FT /note="Sodium ion transport-associated"
FT /evidence="ECO:0000259|Pfam:PF06512"
FT DOMAIN 1148..1422
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1470..1725
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 990..1016
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1055..1105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 434..465
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1067..1085
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFP40279.1"
FT NON_TER 1878
FT /evidence="ECO:0000313|EMBL:KFP40279.1"
SQ SEQUENCE 1878 AA; 213046 MW; A8529F2449576B8F CRC64;
PGPENLRPFT PASLAAIEQR IAEAEALKVK RQQVELPEEE ELKPSSDLEA GKNLPLIYGD
PPLELIGVPL EDLDPFYKDK KTFIVLNKGK SIFRFSATPA LYLLGPFHPI RRGAIKVLIH
SYPCPLMFIM ITILTNCVFM TLSNPPAWSK NVEYTFTGIY TFESLIKILS RGFCIDNFTF
LRDPWNWLDF MVISMAYITE FVDLGNISAL RTFRVLRALK TITVIPGLKT IVGALIQSVK
KLSDVMILTV FCLSVFALIG LQLFMGNLRQ KCVRWPPLND TLLGDLGLGN DTLANGTLYG
NFTDDIASNF TSNSTFDFEA YINDEANFYF LEGALDALLC GNSSDAGKCP EGYQCMKAGR
NPNYGYTSYD TFSWAFLALF RLMTQDFWEN LFQLTLRAAG KTYMIFFVVV IFLGSFYLIN
LILAVVAMAY AEQNDATMLE EQQKEEEFQQ LMEQLKKHQE EQEKVVGGKC GAKMRDLRNR
GRKEGGSDMR GDASIYVKSK NDPHLVQRGG EKQGIKSTRT DSILSCSTSR AGNLAESLRR
QVVVRAQRKH SRKTGQFANH LLLAKTGKSR EGLRDPASPP MEVLVSLKCY LSPFSVLGSL
VSPQYLNSDQ DNAKDCNGQV VPKVVLERSA TVVEVHVRLC LCRPSRVPTP IKPGLEKRVG
SAISVISNAV EELEEAHQKC PPWWYKCAHT FLVWNCCPPW LKLKKFVKLV VMDPFVDLGI
TICIVLNTVF MAMEHYPMTE EFENVLTVGN LVFTGIFTAE MVLKLIALDP YEYFQQGWNI
FDSIIVTLSL VELGLANVQG LSVLRSFRLL RVFKLAKSWP TLNMLIKIIG NSVGALGNLT
LVLAIIVFIF AVVGMQLFGK SYIECVCKIS LDCTLPRWHM NDFFHSFLIV FRILCGEWIE
TMWDCMEVAG QTMCLIVFMM VMVIGNLVVL NLFLALLLSS FSADSLAASD DDGEMNNLQI
AIGRITKGID FVKASVLTLL RRLWKGKKVA PEEEQEPNKR ENSVLNHVDT SQEPKSEYLD
GVTGKEYFFM DELDHMNFIN NPNLTVQVPI ASEESDLYEE TSTQSDTEDA KNPLSSDNAS
SLCSTVDYKP PPPVEEEVAE EAEDSKEPEE CFTEACVKRF PCLYVDITSE RGKVWWNIRK
TCFHIVEHDW FETFIVFMIL LSSGALAFED IYIEQRKVIR TILEYADKVF SYVFVIEMLL
KWVAYGFKVY FTNAWCWLDF LIVDVSIISL TANWLGYSEL GAIKSLRTLR ALRPLRALSR
FEGMRVVVNA LLGAIPSIMN VLLVCLIFWL IFSIMGVNLF AGKYYRCVNT TSGELFDISV
VNNKSDCMAL LHTNEVRWVN VKVNFDNVGL GYLSLLQVAT FKGWMDIMYA AVDSREIEEQ
PVYEINLYMY IYFVIFIIFG AFFTLNLFIG VIIDNFNQQK KKISKDIFMT EEQKKYYNAM
KKLGSKKPQK PIPRPSNKFQ GMVFDFVTKQ VFDITIMILI CLNMVTMMVE TDDQSDLKTS
VLYKINLVFI VIFTGECVLK MFALRYYYFT IGWNIFDFVV VILSILGIVL SDIIEKYFVS
PTLFRVIRLA RIGRVLRLIR GAKGIRTLLF ALMMSLPALF NIGLLLFLVM FIYSIFGMSN
FAYVKKEAGI DDIFNFETFG NSIICLFQIT TSAGWDGLLS PILNSGPPDC DPDLENPGSS
VKGDCGNPSI GIFFFCSYII ISFLIVVNMY IAIILENFNV ATEESSEPLC EDDFEMFYET
WEKFDPDATQ FIAYSTLSDF VDTLQEPLKI PKPNKIKLIT MDLPMVAGDK IHCLDILFAL
TKEVLGDSGE MDALKATMEE KFMAANPSKV SYEPITTTLK RKHEEVCATK IQRAFRRYLL
RRSVKQASYM YRHSKDED
//