ID A0A091KYA8_9GRUI Unreviewed; 2869 AA.
AC A0A091KYA8;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Collagen alpha-3(VI) chain {ECO:0000313|EMBL:KFP44448.1};
DE Flags: Fragment;
GN ORFNames=N324_11403 {ECO:0000313|EMBL:KFP44448.1};
OS Chlamydotis macqueenii (Macqueen's bustard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Gruiformes; Otididae; Chlamydotis.
OX NCBI_TaxID=187382 {ECO:0000313|EMBL:KFP44448.1, ECO:0000313|Proteomes:UP000053330};
RN [1] {ECO:0000313|EMBL:KFP44448.1, ECO:0000313|Proteomes:UP000053330}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N324 {ECO:0000313|EMBL:KFP44448.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Collagen VI acts as a cell-binding protein.
CC {ECO:0000256|ARBA:ARBA00043858}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the type VI collagen family.
CC {ECO:0000256|ARBA:ARBA00044000}.
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DR EMBL; KK759519; KFP44448.1; -; Genomic_DNA.
DR Proteomes; UP000053330; Unassembled WGS sequence.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR CDD; cd01481; vWA_collagen_alpha3-VI-like; 3.
DR CDD; cd01482; vWA_collagen_alphaI-XII-like; 1.
DR CDD; cd01450; vWFA_subfamily_ECM; 2.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 11.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR041900; vWA_collagen_alpha3-VI-like.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR22588:SF6; COLLAGEN ALPHA-4(VI) CHAIN; 1.
DR PANTHER; PTHR22588; UNCHARACTERIZED; 1.
DR Pfam; PF01391; Collagen; 3.
DR Pfam; PF00092; VWA; 11.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00327; VWA; 12.
DR SUPFAM; SSF53300; vWA-like; 12.
DR PROSITE; PS50234; VWFA; 11.
PE 3: Inferred from homology;
KW Collagen {ECO:0000313|EMBL:KFP44448.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053330};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..2869
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001877471"
FT DOMAIN 38..212
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 241..418
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 444..623
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 644..817
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 842..1014
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1035..1211
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1245..1416
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1447..1627
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1647..1820
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 2413..2593
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 2631..2827
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 2056..2384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2119..2135
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2143..2168
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 2869
FT /evidence="ECO:0000313|EMBL:KFP44448.1"
SQ SEQUENCE 2869 AA; 311094 MW; 8A1109971408DE5C CRC64;
MRKHRHLPFA AMFCLLLSGF CSVRAQQQAA VKTVAVADII FLVDSSWSIG KEHFQLIREF
LYDVVKALDV GGNDFRFALV QFSGNPHTEF QLNTYPSTRD VLSHIANMPY MGGGTKTGKG
LEYLIENHLT KAAGSRASEG VPQVIIVLTD GRSQDDVALP SSVLKSAHVN IFAVGVQDAV
EGELKEIASE PFDTHLFNLE NFTALHGIVG DLVANVHSSM TPEKAGAKGL VKDITAQESA
DLIFLIDGSN NVGSVNFQAI RDFLVNLIES LRVGAQQIHI GVVQYSDEPR TEFALNSYST
KADVLDAVKA LSFRGGEEAN TGAALEFVVE NLFTQAGGSR IEEAVPQILV LISGGESSDD
IREGLLAVKQ ASIFSFSIGV LNADSAELQQ IATDGSFAFT ALDIRNLDAL RELLLPNIVG
VAQRLILLEA PTIVTEVIEV NKKDIVFLID GSTALGTGPF NSIRDFVAKI VQRLEVGPDL
IQVAVAQYAD RVKPEFYFNT HQSRKDVMAN VKRMKLMGGT ALNTGSALDF VRNNFFTSAA
GCRMDEGVLP MLVLITGGKS MDAVDQAAAE MKRNRIVILA IGSRNADLAE LQEIAHERDF
VFNPNDFRVQ FMQAILPEVL SPIRTLSGGL IIQEPPSVQV TKRDIIFLLD GSLNVGNANF
PFVRDFVATL VNYLDVGSDK IRVGLVQFSD TPKTEFFLYS YQTKSDIIQR MGQLRPKGGS
VLNTGSALNF VLSNHFTEAG GSRINEQVPQ VLVLVTAGRS ADAFLQVSNE LARAGVLTFA
VGVRSADKAE LEQIAFNPRM VYFMDDFSAL AALPQELNKP ITTYVSGGVE EVPLAPTESK
KDILFLIDGS ANLLGSFPAV RDFVHKVISE LNVGPDATRV AVAQFSDNIQ VEFDFAELPS
KQDMLLKVKR MKIKTGKQLN IGAALDETIR RLFVKEAGSR IEEGIPQFLV LLVAGRSTDD
VEQPSDALKQ TGVVTFAIKA KNADAVELER IVYAPQFILN VESLPQISEL QPNIVNLLKT
IQLQPTVVKR GEKKDVVFLI DGSDGVRRGF PLLKTFVQRV VESLDIGRDK VRVAVAQYSN
VIQPEFLLDT YEDKADLISA IQELKVMGGS PLNTGAALDY LIKNVFTVSS GSRIAEGVPQ
FLILLTADRS QDDVRRPSVV LKTSGTVPFG IGIGNADLTE LQTISFLPDF AISVPDFTQL
DTVQQVVSNR VIRLTKKEIE SLAPDLIFTS PSPAAFFPAA GVKRDVVFMV DGSRYAAQEF
YLIRDLIERI VNNLDVGFDT TRISVVQFSE HPHVEFLLNA HSTKDEVQSA VRRLRPQGGQ
QVNIGEALEF VAKTIFTRPS GSRIEEGVPQ FLVILSSRKS DDDLENPSLQ VKQVGVAPMV
VAKNVDPEDI VQISLSPDYV FQVSSFQELP SLEQKLLTPI ETLTGDQIRR LLGDVQPPTD
SSGDKKDVVF LIDSSDNVRP DGLAHIRDFI GRIVQQLEVG PNKVRIGVVQ FSNNVFPEFY
LKTHRSKNAV LQAIRRLRLR GGSPVNAGKA LDYAVKNYFI KSAGSRIEDG VPQHLVIILG
DRSQDDVNRP ATVITSTSIK PLGVGARNVD RDQLQIITND PERVLVVQDF TGLPTLEKRL
QNILEELPIP TIETPGFLGP GGKKQADIVF LLDGSINLGR ENFQEVLQFV YSVVDAIYRD
GDSIQVGLAQ YNSDVTDEFF LKDYSTKPEI LDAINKVIYK GGRVANTGAA IRHIQAKHFV
KEAGSRIDQR VPQIAFIVTG GKSSDDGPGA SLEIAQKGVK VFAVGVRNID LKDVSSLASE
SATSFRAATA QELSELNEQV LVTLEAAMEE KLCPVTTDVT RDCDLDVILG FDVTDVGPGQ
NIFNSQRGLE SRVESVLNRI TQMQKISCTG NQAPNVRVAI MAQARGGPVE GLDFSEYQPQ
LFERFQGMRT RGPYFLTADT LRSYLAKFRS APSGSTKVII HFTDGADDSM DQLAAASSTL
HTEGVNALIF VGLDRVSDFD KVMQLEFGRG FTYNRPLRVN LLDLDFELAE QLDNIAERTC
CKVPCKCSGQ RGDRGMPGPI GPKGATGDLG YGGYPGDEGG PGERGPPGVN GTQGFQGCPG
HRGTKGSRGF PGEKGELGEM GLDGIDGEEG DKGLPGSSGE KGYAGRRGDK GVKGERGERG
DRGLRGDPGD SGADNTQRGS RGQKGEIGPM GEPGPAGLEG QDGAVGRQGM AGRRGPVGVK
GTKGSVGPAG PAGEQGMRGP QGPSGQTGTP GIRGEQGVPG PRAGGGPPGA PGERGRIGPL
GRKGEPGDPG PKGQNGQRGP RGEMGDDGRD GIGSPGPQGR KGERGFIGYP GPKGGPGDRG
GVGGPGPKGN RGRRGNAGDP GTPGQKGEVG YPGPSGLKGD KGESRDQCAL VRNIKDKCPC
CYGPKECPVF PTELAFAIDT SSGVVRDVFN RMKQTVLRVV NNLTIAESNC PRGARVALVT
YNNEVTTEIR FADARKKSSL LQQIQNFQAT LTTKPRSLET AMSFVARNTF KRARSGFLMR
KVAVFFSNGD TRASPQLNDA VLKLYDAGVM PVFLTSRQDP VLTRALEINN TAVGHAIVLP
ASGNQLNETI RRLLTCHICL DVCDPDPACG FGSQRPVFRD RRAAPTDVDT DIAFIMDSSE
STTPLQFSEM KKYISHLVSN LEISSEPKLS QHHARVAVLQ QAPYEYETNS SFPPVKTEFS
LTDYGSKEKI VNYLHNQMTQ LHGTRAMGSA IEHTMAHIFE SAPNPRDLKV IVLMMTGKVN
KEELAYLQKV VIEAKCKGYF FIVLGIGRKV NTKNIYSLAS EPHDVFFKLV DKPGELHEEP
LLRFGRLLPS FIRSDFAFHL SPEIQKQCEW FQRDQQAKSQ SPGHTGQKA
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