ID A0A091LVI5_CARIC Unreviewed; 2233 AA.
AC A0A091LVI5;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Dynein heavy chain 5, axonemal {ECO:0000313|EMBL:KFP62329.1};
DE Flags: Fragment;
GN ORFNames=N322_02058 {ECO:0000313|EMBL:KFP62329.1};
OS Cariama cristata (Red-legged seriema).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Cariamiformes; Cariamidae; Cariama.
OX NCBI_TaxID=54380 {ECO:0000313|EMBL:KFP62329.1, ECO:0000313|Proteomes:UP000054116};
RN [1] {ECO:0000313|EMBL:KFP62329.1, ECO:0000313|Proteomes:UP000054116}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N322 {ECO:0000313|EMBL:KFP62329.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; KK508789; KFP62329.1; -; Genomic_DNA.
DR Proteomes; UP000054116; Unassembled WGS sequence.
DR GO; GO:0005929; C:cilium; IEA:UniProt.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46961; DYNEIN HEAVY CHAIN 1, AXONEMAL-LIKE PROTEIN; 1.
DR PANTHER; PTHR46961:SF16; DYNEIN, AXONEMAL, HEAVY CHAIN 8; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000054116}.
FT DOMAIN 4..194
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 351..465
FT /note="Dynein heavy chain AAA 5 extension"
FT /evidence="ECO:0000259|Pfam:PF17852"
FT DOMAIN 691..772
FT /note="Dynein heavy chain 3 AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17857"
FT DOMAIN 846..1107
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 1121..1466
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 1495..1715
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 1961..2070
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 2101..2233
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT COILED 1130..1157
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1350..1405
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1656..1683
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFP62329.1"
FT NON_TER 2233
FT /evidence="ECO:0000313|EMBL:KFP62329.1"
SQ SEQUENCE 2233 AA; 254352 MW; 8A4EC786251221F4 CRC64;
FYIFCIFQNP GYAGRQELPE NLKIQFRTVA MMVPDRSIIM RVKLASAGFR DNQVLSRKFY
TLYKLCEEQL SKQVHYDFGL RNILSVLRTL GAVKRSNPKE PEKTVVMRVL RDMNLSKLVD
EDEPLFMSLI NDLFPGITLD KAGYPELQSA IQKQAEKAGL IHHPPWILKL IQLYETQRVR
HGMMTLGPTG AGKTKCINIL MKAMTDCGAP HKEMRMNPKA ITASQMFGTL DVATNDWTDG
IFSTLWRKTL KVKKSEHIWI VLDGPVDAIW IENLNSVLDD NKTLTLANGD RIPMSPSCKI
IFEPHNIDNA SPATVSRNGM VFMSSSVLDW KPILRAWLQT LPVTYSDVLW NCFNAVFQDV
IDFVFSAVTP KMPILECMYI KQAIDLLQGL LSDRDEKQLS EEHIARLFIF AIMWSAGALL
EPDDRLKMEL FLRKHSAVKE LPAVNGEETM FEFGIDACGQ WEHWSKKVPE YIYPKDSVPE
YTSILVPNVD SVRTDFLMHT IMRQGKAVLL IGEQGTAKTV MIKDYTSKYD PDVHLTKCLN
FSSATLPNMF QRSIESYIDK RMGTTYGPPA GKKMTVFIDD INMPVINEWG DQITNEIVRQ
LMEQKGFYNL EKPGEFTNVV DIQFVAAMIH PGGGRNDIPQ RLKRQFTIYN CTLPSSSSID
KIFRTIAEGY FCEQRHFSAE ICKLASALVS TTRKIWQTTK AKMLPTPAKF HYIFNLRDLS
RIWQGILTVT SEVCQSIGVL VALFQHECRR VIADRFISQS DKDWFEDMMI KIASAEHGQN
LFEDKSTELY FVDFLHDVPE ATGDEPDDAE LKAPKIYEPI PSLDNLAERL QMFMQQYNET
IRGSKMDLVF FKDAIIHLIK ISRIIRTPQG NALLVGVGGS GKQSLTRLAS YIAGYESFQI
TLTRTYATNN LLDDLKILYR TAGQRGKGIV FIFTDNEIRD ESFLEYMNNV LASGEVSNLF
ARDEIGEITQ DLIPAMKKEY PRRTPTGENL YNYFLARVRN NLHVVLCFSP VGEKFRTRAL
KFPGLISGCT MDWFQRWPKD ALVAVAQHFL TSYHIECTDE VKQSVVKTMG TFQDIVAEKC
VEYFERYRRR TFVTPKSYLS FIGGYKAIYK EKFASVGSLS ERMRTGLAKL MEAEVSVNQL
SKELVMKEKD LAVASKKADE VLLEVTMKAQ AAEKVKMQVQ KVKDKAQAIV DDIAIDKAAA
EEKLEAARPA LEEAEAALQT IKPSDIATVR KLGKPPHLIM RIMDCVLLLF QRKIDPVTPD
QERPCVKPSW TEALKLMNNS GFLSMLLTFQ KDSITGETVE LLEPYLDMED YNLETAKKVC
GNVAGLCSWT QAMAYFYGIN KEVLPLKANL ALQEGRLAAA QEELNNAQIQ LDEKQMELDQ
VQTMYDTAMK EKQALLDDAE ACRRKMSNAT ALIEGLGGEK LRWTASSKNF QNQIVNLVGN
VLLATGFLSY SGPFNQEYRN LLLQLWKKEM DNSNIPYSND LNLTGMLVDN TTVGEWNLQG
LPNDDLSIQN GIIVTKASRY PLLIDPQGQG KIWIKNKEKN NGLQITAMNH KFFRSHIEDC
LSLGRPLLIE DVGEELDPAL DNILEKNFIK SGSAHKVKVG DKEVDLMKGF TLYITTKLAN
PAYTPEISAR TTVIDFTVTM KGLEDQLLGR VILTEKQELE AERVKLMEEV TSNKRKMQEL
EDNLLFRLTS TEGSLVEDES LIEVLRITKT TAEEVSEKLN IAAETEVKIN TAREEYRPVA
CRGSILYFLV VEMSLVNVMY QTSLRQFLGI FDLSVERSQK SQITAKRVVY IIEHLTYEVF
KYTVRGLYEN HRFLFTLLLA LKIDLQAKKI SHTEFETLIK GGASLDLNSV EPKPKKWILD
MTWLNLVQLS SLYPFNQLLV QVVRNEKSWK AWFDEEAPEK AVIPDGYDSL LDQFRKLLLV
RSWCPDHTVA QARHYIAESL GGKYAEGFIL EMEAMWTESD CRTPLTCFLS MGSDPTENIE
RLAKSKNIPC RAISMGQGQE VHARRLLNQC MQDGGWVLLQ NCHLGLEFLS ELMDTITTAE
SMSESFRTWI TTEAHSEFPI NILQSSIKFT NEPPQGVKAG LKRTYSAVTQ DHLEVSNMPQ
WKPLLYAVAF LHTTVQERRK FGPLGWNIPY EFNQADFAAS VQFVQNHLDD MDIKHGVNWS
CVRYMLGEVQ YGGRVTDDLD KALLNTYARV WFGEHMFSEK FCFYKDYVIP KGKTVEDYLQ
YIEELPVIDT PEV
//
