ID   A0A091M4L2_CARIC        Unreviewed;       389 AA.
AC   A0A091M4L2;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Short-chain dehydrogenase/reductase family 42E member 1 {ECO:0000313|EMBL:KFP66728.1};
DE   Flags: Fragment;
GN   ORFNames=N322_05043 {ECO:0000313|EMBL:KFP66728.1};
OS   Cariama cristata (Red-legged seriema).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Cariamiformes; Cariamidae; Cariama.
OX   NCBI_TaxID=54380 {ECO:0000313|EMBL:KFP66728.1, ECO:0000313|Proteomes:UP000054116};
RN   [1] {ECO:0000313|EMBL:KFP66728.1, ECO:0000313|Proteomes:UP000054116}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N322 {ECO:0000313|EMBL:KFP66728.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC       {ECO:0000256|ARBA:ARBA00009219, ECO:0000256|RuleBase:RU004475}.
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DR   EMBL; KK521876; KFP66728.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A091M4L2; -.
DR   Proteomes; UP000054116; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR   PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR   Pfam; PF01073; 3Beta_HSD; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|RuleBase:RU004475};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU004475};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054116};
KW   Transmembrane {ECO:0000256|RuleBase:RU004475};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU004475}.
FT   TRANSMEM        284..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004475"
FT   TRANSMEM        365..383
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004475"
FT   DOMAIN          12..281
FT                   /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT                   /evidence="ECO:0000259|Pfam:PF01073"
FT   NON_TER         389
FT                   /evidence="ECO:0000313|EMBL:KFP66728.1"
SQ   SEQUENCE   389 AA;  43491 MW;  C0035BABF9859F32 CRC64;
     MEPENTAKET VVITGGGGYF GFRLGCAIYQ KGVDVILFDV VKPLQTVPEG IKFVQGDVCC
     LSEVEEALKD VICVFHIASY GMSGREQLNR KLIEDVNVKG TENVIQACKS TGVSGLVYTS
     TYNVIFGGQI IENGDESLPY LPLHLHPDHY SRTKSLAEMK VLEANGAELG NGKGVLRTCA
     LRPAGIYGPG EQRHLPRIVS YIERGLFKFV YGDPLSLVEF VHVDNLVQVH ILASEALKAN
     KKHIAAGQAY FISDGRPVNN FEFFRPLVEG LGYKFPTCRL PLSLVYFFAF LTEVVHFLVG
     HVYNFQPLLT RTEVYKTGVT HYFSMEKARK ELGYEPQQYN LNEVVEWFRS QGCGPKPRRH
     TITHLVRDGA LLLLLMAVMV SWFPSTVTF
//