ID A0A091M5H3_CARIC Unreviewed; 698 AA.
AC A0A091M5H3;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 08-NOV-2023, entry version 38.
DE SubName: Full=Calpain-8 {ECO:0000313|EMBL:KFP67068.1};
GN ORFNames=N322_13147 {ECO:0000313|EMBL:KFP67068.1};
OS Cariama cristata (Red-legged seriema).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Cariamiformes; Cariamidae; Cariama.
OX NCBI_TaxID=54380 {ECO:0000313|EMBL:KFP67068.1, ECO:0000313|Proteomes:UP000054116};
RN [1] {ECO:0000313|EMBL:KFP67068.1, ECO:0000313|Proteomes:UP000054116}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N322 {ECO:0000313|EMBL:KFP67068.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase C2 family.
CC {ECO:0000256|ARBA:ARBA00007623}.
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DR EMBL; KK522825; KFP67068.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091M5H3; -.
DR MEROPS; C02.007; -.
DR Proteomes; UP000054116; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00214; Calpain_III; 1.
DR CDD; cd00044; CysPc; 1.
DR CDD; cd16191; EFh_PEF_CAPN8; 1.
DR Gene3D; 2.60.120.380; -; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR033883; C2_III.
DR InterPro; IPR022684; Calpain_cysteine_protease.
DR InterPro; IPR022682; Calpain_domain_III.
DR InterPro; IPR022683; Calpain_III.
DR InterPro; IPR036213; Calpain_III_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR001300; Peptidase_C2_calpain_cat.
DR PANTHER; PTHR10183; CALPAIN; 1.
DR PANTHER; PTHR10183:SF374; CALPAIN-8; 1.
DR Pfam; PF01067; Calpain_III; 1.
DR Pfam; PF00648; Peptidase_C2; 1.
DR PRINTS; PR00704; CALPAIN.
DR SMART; SM00720; calpain_III; 1.
DR SMART; SM00230; CysPc; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF49758; Calpain large subunit, middle domain (domain III); 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS50203; CALPAIN_CAT; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00239};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU00239}; Reference proteome {ECO:0000313|Proteomes:UP000054116};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807, ECO:0000256|PROSITE-
KW ProRule:PRU00239}.
FT DOMAIN 45..344
FT /note="Calpain catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50203"
FT DOMAIN 600..635
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT ACT_SITE 105
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
FT ACT_SITE 262
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
FT ACT_SITE 286
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
SQ SEQUENCE 698 AA; 79092 MW; 2358CED15B76C166 CRC64;
MARVAARLCQ ERAVADGLGS NANAIKYLKQ DYEALKRQCL QAGTLFKDEE FPACPSVLGY
RDLGPYSFKT QGIIWKRPME LCASPQFIIG GATRTDVCQG ELGDCWLLAA IASLTLNPDV
LYRVVPKAQS FQKDYAGIFH FQFWQYGEWV DVVVDDRLPT KNGKLLFVHS EEGNEFWSAL
LEKAYAKLNG SYEALTGGST MEAFEDFTGG ISESYELRRA PSNLYQIIQK ALKAGSLLGC
SIDITTAAEV EAITSLKLVK GHAYSVTGAE EVYYRGRPEK LVRLRNPWGE VEWTGAWSDN
APEWNYVDPK QKQALDKQVD DGEFWMAFSD FQRQFTRLEI CNLTPDTLTS NEVNKWDLTL
FNGQWRRGST AGGCQNYQAT YWTNPQFKIR LDEPDDDHEG SLNEPCCTIL VGLMQKNRRR
QKKMGEALLS IGYSLYQLAH DTDIHANRAF FARNQPAARS DPYVNLREVS SRIKLPRGEY
LIVPSTFEPY KNGEFCLRVF SEKQAKTQMV GDVVSAKPYE PHVNNKDIDD EFKTLYQKLS
GEDCEVTATE LQTILNQVLV KRKDIKSDGF NINTCREMIS LLDTNGTGTL GLVEFKTLWM
KIRKYLAIYK KVDGDYSGTI DSHEMRNALR EAGFMLSDQV QHSIVTRYAC SKLTIDFDGF
VACMIRLETL FKAFHLLDKD KSGVIQLSLA EWLCCTMV
//
