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Database: UniProt
Entry: A0A091NW66_HALAL
LinkDB: A0A091NW66_HALAL
Original site: A0A091NW66_HALAL 
ID   A0A091NW66_HALAL        Unreviewed;      3259 AA.
AC   A0A091NW66;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   20-DEC-2017, entry version 20.
DE   SubName: Full=Ryanodine receptor 2 {ECO:0000313|EMBL:KFP96923.1};
DE   Flags: Fragment;
GN   ORFNames=N329_07873 {ECO:0000313|EMBL:KFP96923.1};
OS   Haliaeetus albicilla (White-tailed sea-eagle).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Falconiformes; Accipitridae;
OC   Accipitrinae; Haliaeetus.
OX   NCBI_TaxID=8969 {ECO:0000313|EMBL:KFP96923.1, ECO:0000313|Proteomes:UP000054379};
RN   [1] {ECO:0000313|EMBL:KFP96923.1, ECO:0000313|Proteomes:UP000054379}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N329 {ECO:0000313|EMBL:KFP96923.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; KK642645; KFP96923.1; -; Genomic_DNA.
DR   Proteomes; UP000054379; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd00051; EFh; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 1.
DR   Pfam; PF02026; RyR; 2.
DR   Pfam; PF00622; SPRY; 1.
DR   SMART; SM00449; SPRY; 1.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   PROSITE; PS50188; B302_SPRY; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000054379};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:KFP96923.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054379};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2887   2905       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3106   3126       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3180   3199       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        1    176       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     2630   2665       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED     1671   1691       {ECO:0000256|SAM:Coils}.
FT   COILED     3021   3044       {ECO:0000256|SAM:Coils}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:KFP96923.1}.
FT   NON_TER    3259   3259       {ECO:0000313|EMBL:KFP96923.1}.
SQ   SEQUENCE   3259 AA;  371705 MW;  363A7FE00082D7CA CRC64;
     RFMLRRTKPD YSTSHSARLT EDVLADDRDD YDYLMQTSTY YYSVRIFPGQ EPANVWVGWI
     TSDFHQYDTS FDLDRVRTVT VTLGDEKGKV HESIKRSNCY MVCAGESMSP GQGRNNNGLE
     IGCLVDAASG LLTFTANGKE LGTYYQVEPS TKLFPAVFAQ ATSPNVFQFE LGRIKNVMPL
     SAGLFKSEHK NPVSQCPPRL HVQFLTHVLW SRVPNHFLKV DVSRISERQG WMIQCLNPLQ
     FMALHIPEEN RTIDILELTE QEELLKFHYH TLRLYSAVCA LGNNRVAHAM CSHVDESQLL
     YAIENKYMPG LLRAGYYDLL IDIHLNTYAT ARLMMNNEFI VPMTDETKSI TLFPDENKKH
     GLPGIGLSTS LRPRMQFSSP SFVSISSECF QFSPEFPLET LKAKTIEMLT EAVQEGSLHV
     RDPVGGSTEF LFVPLIKLFY TLLIMGIFHN GDLKHILQLI EPRVFKEAMS QEDEVDFSEK
     ELSSDELKSE EGEEETRGEQ VPKEGLLQMK LPEPVKLQMC HLLQYLCDCQ VRHRIEAIVA
     FSDDFVAKLQ ENQRFRYNEV MQALNMSAAL TARKTKEFRS PPQEQINMLL NFKDDKNDCP
     CPEEIRDQLL DFHEDLMTHC GIELDEDGTL DGNSDLTIRG RLLYLMEKVT YLKKKQAEKP
     VDDDAKTSST LQQLISDTMV RWAQESVIED PELVRAMFVL LHRQYDGIGG LVRALPKTYT
     INSVSVEDTI NLLASLGQIR SLLSVRMGKE EEKLMIRGLG DIMNNKVFYQ HPNLMRALGM
     HETVMEVMVN VLGGGESKEI TFPKMVANCC RFLCYFCRIS RQNQKAMFDH LSYLLENSSV
     GLASPSMRGS TPLDVAAASV MDNNELALAL REPDLEKVVR YLAGCGLQSC PLLISKGYPD
     IGWNPVEGER YLDFLRFAVF CNGESVEENA NVVVRLLIRR PECFGPALRG EGGNGLLAAM
     EEAIQISEDP TRDGPSPSNG SSKTLEMEEQ EDDTIHMGNA IMTFYAALID LLGRCAPEMH
     LIHAGKGEAI RIRSILRSLI PLEDLVGVIS IPFHMPTIAK DGTVVEPDMS AGFCPDHKAA
     MVLFLDRVYG IEDQDFLLHL LEVGFLPDLR AAASLDTAAL SATDMALALN RYLCTAVLPL
     LTRCAPLFAG TEHHASLIDS LLHTVYRLSK GCSLTKAQRD SIEECLLSIC GQLRPSMMQH
     LLRRLVFDVP LLNEHAKMPL KLLTNHYERC WKYYCLPGGW GNFGAASEEE LHLSRKLFWG
     IFDALSQKKY EQELFKLALP CLSAVAGALP PDYMESNYVN MMEKQSSMDS DGNFNPQPVD
     TSNITIPEKL EYFINKYAEH SHDKWSMEKF ANGWTYGETY SESAKVQPLM KQYKLLSEKE
     KEIYRWPIKE SLKTMLAWGW RIERTREGDS MALYNRTRRI SQTSQISVDT AHGYTPRAID
     MSNVTLSRDL HAMAEMMAEN YHNIWAKKKK MELEAKGGGN HPLLVPYDTL TAKEKAKDRE
     KAQDILKFLQ INGYVVSRGL KDLELDTPSI EKRFAYSFLQ QLIRYVDEAH QYILEFDGGS
     RGKGEHFPYE QEIKFFAKVV LPLIDQYFKN HRLYFLSAAS RPLSSGGHAS NKEKEMVTSL
     FCKLGVLVRH RISLFGNDAT SIVNCLHILG QTLDARTVMK TGLESVKMAL RAFLDNAAED
     LEKTMENLKQ GQFTHSRNQP KGVTQIINYT TVALLPVLSS LFEHIGQHQF GEDLILEDVQ
     VSCYRILASL YALGTSKSIY VERQRSALGE CLAAFSGAFP VAFLETHLNK HNIYSIYNTK
     NARDRAVLNL PTSVEEVCPN IPSLVKLMEE IVELAESGIR YTQMPHIMEV ILPMLCSYMS
     HWWEHGPENN PDKAEMCCTA LTSEHMNTLL GNILKIIYNN LGIDEGAWMK RLAVFSQPII
     SKAKPQLLKT HFLPLMDKLK KKAAVVVSDE EHLRAEGRGD MSEAELLILD EFTTLARDLY
     AFYPLLIRFV DYNRAKWLKE PNPEAEELFR MVAEVFIYWS KSHNFKREEQ NFVVQNEINN
     MSFLISDTKS KMSKAAVSDQ ERKKMKRKGD RYSMQTSLIV AALKRLLPIG LNICAPGDQE
     LIALAKNRFS MKDTEDEVRD IIRSNLHLQG KLEDPAIRWQ MALYKDLPNR TEDSSDPEKT
     VERVLDIANV LFHLEQVRHI FPVEHPQRSK KAVWHKLLSK QRKRAVVACF RMAPLYNLPR
     HRAVNLFLQG YDKSWIETEE HYFEDKLIED LAKPGEEPPE EDESLKRVDP LHQLILLFSR
     TALTEKCKLE EDFLYMAYAD IMAKSCHDEE DDDGEEEVKS FEEKEMEKQK LLYQQARLHD
     RGAAEMVLQT ISASKGEMGP MVAATLKLGI AILNGGNSTV QQKMLDYLKD KKDVGFFQSL
     AGLMQSCSVL DLNAFERQNK AEGLGMVTEE GSGEKVMQDD EFTCDLFRFL QLLCEGHNSD
     FQNYLRTQTG NNTTVNIIIS TVDYLLRVQE SISDFYWYYS GKDVIDEQGQ RNFSKAIQVA
     KQVFNTLTEY IQGPCTGNQQ SLAHSRLWDA VVGFLHVFAH MQMKLSQDSS QIELLKELMD
     LQKDMVVMLL SMLEGNVVNG TIGKQMVDML VESSNNVEMI LKFFDMFLKL KDLTSSDAFK
     EYDPDGKGII SKRDFHKAME SHKHYTQSET EFLLSCAETD ENETLDYEEF VKRFHEPAKD
     IGFNVAVLLT NLSEHMPHDT RLQTFLELSE SVLNYFQPFL GRIEIMGSAK RIERVYFEIS
     ESSRTQWEKP QVKESKRQFI FDVVNEGGEK EKMELFVNFC EDTIFEMQLA AQISESDLNE
     RSANKEENEK DKPEEQDPRM GFFSLVTMKS ALVALKYNLM TLMKMLSMKS LKKQMKKVKK
     MTMKDMVMAL FSSYWSILMG LLHFACSVVR GFFRIICSLL LGGSLVEGAK KIKVAELLAN
     MPDPTQDEVR GEGEEGERKP TEAALPAEDL TDLRTLSDES DLLSDIFGLD LKREGGQYKL
     IPHNPNAGLS DLLSTPSLAP MPEVQEKIQV KEDEKEEKEE TKSEPEKAEG EDGEKEEKAK
     EDKGKQKLRQ LHTHRYGEPE VQESAFWKKI IAYQQKLLNY FARNFYNMRM LALFVAFAIN
     FILLFYKVST SAVTEEKEVP VVSAAESTKL NSLESDNQRV IAVHYVLEES SGYMEPTLRI
     LAILHTVISF FCIIGYYCLK VPLVIFKREK EVARKLEFDG LYITEQPSED DIKGQWDRLV
     INTQSFPNNY WDKFVKRKV
//
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