ID A0A091P2W1_HALAL Unreviewed; 1659 AA.
AC A0A091P2W1;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
DE Flags: Fragment;
GN ORFNames=N329_04817 {ECO:0000313|EMBL:KFQ01096.1};
OS Haliaeetus albicilla (White-tailed sea-eagle) (Falco albicilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Accipitriformes; Accipitridae;
OC Accipitrinae; Haliaeetus.
OX NCBI_TaxID=8969 {ECO:0000313|EMBL:KFQ01096.1, ECO:0000313|Proteomes:UP000054379};
RN [1] {ECO:0000313|EMBL:KFQ01096.1, ECO:0000313|Proteomes:UP000054379}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N329 {ECO:0000313|EMBL:KFQ01096.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability of
CC excitable membranes. Assuming opened or closed conformations in
CC response to the voltage difference across the membrane, the protein
CC forms a sodium-selective channel through which Na(+) ions may pass in
CC accordance with their electrochemical gradient.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR EMBL; KK649704; KFQ01096.1; -; Genomic_DNA.
DR Proteomes; UP000054379; Unassembled WGS sequence.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.5.1190; iswi atpase; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 3.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR008053; Na_channel_a5su.
DR InterPro; IPR001696; Na_channel_asu.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR024583; Na_trans_cytopl.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF288; SODIUM CHANNEL PROTEIN; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR Pfam; PF06512; Na_trans_assoc; 1.
DR Pfam; PF11933; Na_trans_cytopl; 1.
DR PRINTS; PR00170; NACHANNEL.
DR PRINTS; PR01666; NACHANNEL5.
DR SMART; SM00015; IQ; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 3.
DR PROSITE; PS50096; IQ; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel {ECO:0000256|RuleBase:RU361132, ECO:0000313|EMBL:KFQ01096.1};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361132};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361132};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000054379};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU361132};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU361132};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361132};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361132};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU361132}.
FT TRANSMEM 57..82
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 384..402
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 414..437
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 449..473
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 494..527
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 582..607
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 878..896
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 917..933
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 945..964
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1009..1029
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1119..1142
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1201..1219
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1231..1253
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1265..1284
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1332..1354
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1421..1444
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT DOMAIN 9..88
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 174..333
FT /note="Voltage-gated Na+ ion channel cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF11933"
FT DOMAIN 383..613
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 621..872
FT /note="Sodium ion transport-associated"
FT /evidence="ECO:0000259|Pfam:PF06512"
FT DOMAIN 876..1151
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1200..1454
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 127..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 207..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1634..1659
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 79..113
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 148..168
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 236..263
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ01096.1"
FT NON_TER 1659
FT /evidence="ECO:0000313|EMBL:KFQ01096.1"
SQ SEQUENCE 1659 AA; 188609 MW; 3A2B04A512FF1C4C CRC64;
CPEGYICLKA GENPDHGYTS FDTFGWAFLS LFRLMTQDCW ERLYQQTLRS AGKIYMLFFM
LVIFLGSFYL VNLILAVVAM AYEEQNQATI AETEEKERKF REAMEMLKKE QEALAAKGID
SMSLSSLEMS PLSSKNAKER RNKRKKKKSL GAEEYGEDQR NPKCDYDDGQ RRMTLLGISY
GPSANLVKRR TSHGSIFSFR LRGRDTGSET DFADDEISTA GENESHRGSL LIPRSGRRPS
VQSQVSHSSH PTTPNYTQTG KRNSSVDCNG VVSLIGGGTG ALNPDPTSPA GLLLPPVIME
KPGTGDLLLM PHRASVDHSE EPFQRQRAVS AVSIITSALE ELEESHQKCP PCWNHFAVKF
LIWDCCPLWL LIKKFVKFVV MDPFTDLTIT LCIVLNTLFM ALEHYKMTKE FDHMLYIGNL
VFTGIFTAEM IFKVIALDPY YYFQQGWNIF DSIIVILSLM ELGLSSMGNL SVLRSFRLLR
VFKLAKSWPT LNTLIKIIGN SVGALGNLTL VLAIIVFIFA VVGMQLFGKS YIDNVKKIST
TGNLPRWHMN DFFHSFLIIF RILCGEWIET MWDCMEVAGQ PLCLLVFLLV MVIGNLVVLN
LFLALLLSSF SADNLSAPDE DGEMNNLQLA FARINRGLRY VKHTTWNFCC NVLRHPKTTA
EKKAMMKLAA QNTGALNNCV NSHTTADLGK DMENHKENHA EDGMNKNGEK HLGITDNDDF
MTNPDLSICV PIAVGESDIE EEDEEQSTFT EMEQEKQLQL RGQRCQSPGV RSQNSEICEE
LSELHVDKQL KAEPPPPVGQ KELDEISLSE GSTVDLTNPA ELLEQIPEFA EELMEPEDCF
PEVCVRFFPC CSVDITKFPG KIWWRLRKTC YRIVEHNWFE TFIIFMILLS SGALAFEDIY
LEDRKNIKTM LEYADKIFTY IFVLEMLLKW VAYGFKKYFT NAWCWLDFLI VDVSLISLIA
NTLGYSEMGP IKSLRTLRAL RPLRALSRFE GMRVVVNALV GAIPSIMNVL LVCLIFWLIF
SIMGVNLFAG KFGKCINKTE GDMPLDSKII NNMSDCILYN VSGTFYWTKV KVNFDNVGAG
YLALLQVATF KGWMDIMYAA VDSRECEEQP EWECNLYMYL YFVIFIIFGS FFTLNLFIGV
IIDNFNQQKK KISGQDIFMT EEQKKYYNAM KKLGSKKPQK PIPRPLNKYQ GFIFDVVSKQ
AFDVSIMILI CLNMVTMMVE TDDQSQEKVN ILHKINMLFV AIFTGECIIK MLALRHYYFT
NGWNIFDFVV VILSIVGTVL SDIIQKYFFS PTLFRVIRLA RIGRILRLIR GAKGIRTLLF
ALMMSLPALF NIGLLLFLVM FIYAIFGMAN FAYVKKEHGI DDMFNFQTFA NSMLCLFQIT
TSAGWDGLLN PILNTGPPYC DPNLPNANGS KGDCGSPAVG ILFFVTYIII SFLIVVNMYI
AIILENFSVA TEESTEPLSE DDFDMFYEIW EKFDPEATQF IEYSALSDFA DALSEPLRIA
KPNKIKLIAM DLPMVSGDRI HCLDILFAFT KRVLGESGEM DALKIQMEEK FMAANPSKIS
YEPITTTLRR KQEEVSAIII QRAYRRHLFR RSMKQASYLY RHRTFDGSIL EDDAPEKEGL
IAFMMNENYG RPIDKSETLS STSFPPSYDS VTRGTSDNL
//