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Database: UniProt
Entry: A0A091P2W1_HALAL
LinkDB: A0A091P2W1_HALAL
Original site: A0A091P2W1_HALAL 
ID   A0A091P2W1_HALAL        Unreviewed;      1659 AA.
AC   A0A091P2W1;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   10-MAY-2017, entry version 18.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
DE   Flags: Fragment;
GN   ORFNames=N329_04817 {ECO:0000313|EMBL:KFQ01096.1};
OS   Haliaeetus albicilla (White-tailed sea-eagle).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Falconiformes; Accipitridae;
OC   Accipitrinae; Haliaeetus.
OX   NCBI_TaxID=8969 {ECO:0000313|EMBL:KFQ01096.1, ECO:0000313|Proteomes:UP000054379};
RN   [1] {ECO:0000313|EMBL:KFQ01096.1, ECO:0000313|Proteomes:UP000054379}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N329 {ECO:0000313|EMBL:KFQ01096.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; KK649704; KFQ01096.1; -; Genomic_DNA.
DR   Proteomes; UP000054379; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR008053; Na_channel_a5su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PRINTS; PR01666; NACHANNEL5.
DR   SMART; SM00015; IQ; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000054379};
KW   Ion channel {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000313|EMBL:KFQ01096.1};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054379};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     57     82       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    384    402       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    414    437       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    449    473       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    494    527       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    582    607       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    878    896       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    917    933       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    945    964       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1009   1029       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1119   1142       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1201   1219       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1231   1253       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1265   1284       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1332   1354       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1421   1444       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN        7     88       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      145    333       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      384    611       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      621    872       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN      876   1150       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1200   1454       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED       79    113       {ECO:0000256|SAM:Coils}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:KFQ01096.1}.
FT   NON_TER    1659   1659       {ECO:0000313|EMBL:KFQ01096.1}.
SQ   SEQUENCE   1659 AA;  188609 MW;  3A2B04A512FF1C4C CRC64;
     CPEGYICLKA GENPDHGYTS FDTFGWAFLS LFRLMTQDCW ERLYQQTLRS AGKIYMLFFM
     LVIFLGSFYL VNLILAVVAM AYEEQNQATI AETEEKERKF REAMEMLKKE QEALAAKGID
     SMSLSSLEMS PLSSKNAKER RNKRKKKKSL GAEEYGEDQR NPKCDYDDGQ RRMTLLGISY
     GPSANLVKRR TSHGSIFSFR LRGRDTGSET DFADDEISTA GENESHRGSL LIPRSGRRPS
     VQSQVSHSSH PTTPNYTQTG KRNSSVDCNG VVSLIGGGTG ALNPDPTSPA GLLLPPVIME
     KPGTGDLLLM PHRASVDHSE EPFQRQRAVS AVSIITSALE ELEESHQKCP PCWNHFAVKF
     LIWDCCPLWL LIKKFVKFVV MDPFTDLTIT LCIVLNTLFM ALEHYKMTKE FDHMLYIGNL
     VFTGIFTAEM IFKVIALDPY YYFQQGWNIF DSIIVILSLM ELGLSSMGNL SVLRSFRLLR
     VFKLAKSWPT LNTLIKIIGN SVGALGNLTL VLAIIVFIFA VVGMQLFGKS YIDNVKKIST
     TGNLPRWHMN DFFHSFLIIF RILCGEWIET MWDCMEVAGQ PLCLLVFLLV MVIGNLVVLN
     LFLALLLSSF SADNLSAPDE DGEMNNLQLA FARINRGLRY VKHTTWNFCC NVLRHPKTTA
     EKKAMMKLAA QNTGALNNCV NSHTTADLGK DMENHKENHA EDGMNKNGEK HLGITDNDDF
     MTNPDLSICV PIAVGESDIE EEDEEQSTFT EMEQEKQLQL RGQRCQSPGV RSQNSEICEE
     LSELHVDKQL KAEPPPPVGQ KELDEISLSE GSTVDLTNPA ELLEQIPEFA EELMEPEDCF
     PEVCVRFFPC CSVDITKFPG KIWWRLRKTC YRIVEHNWFE TFIIFMILLS SGALAFEDIY
     LEDRKNIKTM LEYADKIFTY IFVLEMLLKW VAYGFKKYFT NAWCWLDFLI VDVSLISLIA
     NTLGYSEMGP IKSLRTLRAL RPLRALSRFE GMRVVVNALV GAIPSIMNVL LVCLIFWLIF
     SIMGVNLFAG KFGKCINKTE GDMPLDSKII NNMSDCILYN VSGTFYWTKV KVNFDNVGAG
     YLALLQVATF KGWMDIMYAA VDSRECEEQP EWECNLYMYL YFVIFIIFGS FFTLNLFIGV
     IIDNFNQQKK KISGQDIFMT EEQKKYYNAM KKLGSKKPQK PIPRPLNKYQ GFIFDVVSKQ
     AFDVSIMILI CLNMVTMMVE TDDQSQEKVN ILHKINMLFV AIFTGECIIK MLALRHYYFT
     NGWNIFDFVV VILSIVGTVL SDIIQKYFFS PTLFRVIRLA RIGRILRLIR GAKGIRTLLF
     ALMMSLPALF NIGLLLFLVM FIYAIFGMAN FAYVKKEHGI DDMFNFQTFA NSMLCLFQIT
     TSAGWDGLLN PILNTGPPYC DPNLPNANGS KGDCGSPAVG ILFFVTYIII SFLIVVNMYI
     AIILENFSVA TEESTEPLSE DDFDMFYEIW EKFDPEATQF IEYSALSDFA DALSEPLRIA
     KPNKIKLIAM DLPMVSGDRI HCLDILFAFT KRVLGESGEM DALKIQMEEK FMAANPSKIS
     YEPITTTLRR KQEEVSAIII QRAYRRHLFR RSMKQASYLY RHRTFDGSIL EDDAPEKEGL
     IAFMMNENYG RPIDKSETLS STSFPPSYDS VTRGTSDNL
//
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