ID A0A091PA62_HALAL Unreviewed; 740 AA.
AC A0A091PA62;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=ARF GTPase-activating protein GIT2 {ECO:0000313|EMBL:KFQ04812.1};
DE Flags: Fragment;
GN ORFNames=N329_08155 {ECO:0000313|EMBL:KFQ04812.1};
OS Haliaeetus albicilla (White-tailed sea-eagle) (Falco albicilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Accipitriformes; Accipitridae;
OC Accipitrinae; Haliaeetus.
OX NCBI_TaxID=8969 {ECO:0000313|EMBL:KFQ04812.1, ECO:0000313|Proteomes:UP000054379};
RN [1] {ECO:0000313|EMBL:KFQ04812.1, ECO:0000313|Proteomes:UP000054379}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N329 {ECO:0000313|EMBL:KFQ04812.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KK655805; KFQ04812.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091PA62; -.
DR Proteomes; UP000054379; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007420; P:brain development; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 1.20.120.330; Nucleotidyltransferases domain 2; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR047161; GIT-like.
DR InterPro; IPR032352; GIT1/2_CC.
DR InterPro; IPR022018; GIT1_C.
DR InterPro; IPR013724; GIT_SHD.
DR PANTHER; PTHR46097:SF4; ARF GTPASE-ACTIVATING PROTEIN GIT2; 1.
DR PANTHER; PTHR46097; G PROTEIN-COUPLED RECEPTOR KINASE INTERACTING ARFGAP; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF12205; GIT1_C; 1.
DR Pfam; PF16559; GIT_CC; 1.
DR Pfam; PF08518; GIT_SHD; 2.
DR SMART; SM00248; ANK; 3.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00555; GIT; 2.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS50115; ARFGAP; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000054379};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 1..107
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT REPEAT 149..181
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 361..406
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 471..512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 537..625
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 427..461
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 391..405
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 471..488
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 537..555
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 556..570
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 610..625
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ04812.1"
FT NON_TER 740
FT /evidence="ECO:0000313|EMBL:KFQ04812.1"
SQ SEQUENCE 740 AA; 82635 MW; F8E4E224FBAD4613 CRC64;
DPCWASINRG ILICDECCSV HRSLGRHISQ VRHLKHTPWP PTLLQMVETL YSNGANSIWE
HSLLDPASVM SGRRKASPQD KVHPNKAEFI RAKYQMLAFV HRLPCREDDS VTAKDLSKQL
HSSVRTGNLE TCLRLLSLGA QANFFHPEKG NTPLHVAAKA GQTLQAELLA VYGADPGTQD
SNGKTPVDYA RQGGHHELAE RLVEIQYELT DRLAFYLCGR KPEHKNGQHF VIPQMADSSL
DLSELAKAAK KKLQSLSNHL FEELAMDVYD EVDRRETDAV WLATQNHSTL VTETTVVPFL
PVNPEYSSTR NQGRQKLARF NAHEFATLVI DILSDAKRRQ QGNPLTGSKE NVELILKSIS
NQHSSESQDN DQPDYDSVAS DEDTDLETNA AKSNRQKSLD SDLSDGPVTA QEYMQVKNAL
VASEVKIQQL MKVNINLSDE LRIMQKKLQT LQSENTNLRR QATTNIYQVQ TGSEYTDPAN
NSSLKRRPSA RGSRPMSMYE TGSGQKPYLP MGEVTYPEES ITRLQPFPPH IGRSAFVTSS
SSLPSFPSTL SWSRDESTRR ASKLEKQSSV SESDYDNPTT PLELEETGSG RKGRQRSVLW
QGEGSIPEDA DTAPSSSLPS TEDVIRKTEQ ITKNIQELLR AAQENKHDSY IPCSERIHVA
VTEMAALFPK KPKSELVRTS LRLLTSSAYR LQSECKKTLP VETCPTTDIQ LVTQQVIQCA
YDIAKAAKQL VTITTKENNN
//
