ID   A0A091PAE2_LEPDC        Unreviewed;      1083 AA.
AC   A0A091PAE2;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE            EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN   ORFNames=N330_14242 {ECO:0000313|EMBL:KFQ04580.1};
OS   Leptosomus discolor (Madagascar cuckoo roller) (Cuculus discolor).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Coraciiformes; Leptosomidae; Leptosomus.
OX   NCBI_TaxID=188344 {ECO:0000313|EMBL:KFQ04580.1, ECO:0000313|Proteomes:UP000053001};
RN   [1] {ECO:0000313|EMBL:KFQ04580.1, ECO:0000313|Proteomes:UP000053001}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N330 {ECO:0000313|EMBL:KFQ04580.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; KK670441; KFQ04580.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A091PAE2; -.
DR   PhylomeDB; A0A091PAE2; -.
DR   Proteomes; UP000053001; Unassembled WGS sequence.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR   GO; GO:0000209; P:protein polyubiquitination; IEA:InterPro.
DR   CDD; cd00078; HECTc; 1.
DR   Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR   InterPro; IPR044611; E3A/B/C-like.
DR   InterPro; IPR000569; HECT_dom.
DR   InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   PANTHER; PTHR45700; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR   PANTHER; PTHR45700:SF2; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR   Pfam; PF00632; HECT; 1.
DR   SMART; SM00119; HECTc; 1.
DR   SMART; SM00015; IQ; 1.
DR   SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR   PROSITE; PS50237; HECT; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   4: Predicted;
KW   Ligase {ECO:0000313|EMBL:KFQ04580.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053001};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW   ECO:0000256|PROSITE-ProRule:PRU00104}.
FT   DOMAIN          744..1083
FT                   /note="HECT"
FT                   /evidence="ECO:0000259|PROSITE:PS50237"
FT   REGION          1..40
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          358..382
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        16..40
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        1051
FT                   /note="Glycyl thioester intermediate"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ   SEQUENCE   1083 AA;  123963 MW;  3A1B97429F1307E4 CRC64;
     MFSFEGDFKT RPKVSLGGAS RKEEKASLLH RTQEERRKRE EERRRLKNAI IIQSFVRGYR
     DRKHQYSIQR SEFDRCADLA QSGGTFSTAN GANLTLLVRQ LLFFYRQNED SKRLVWMCQN
     LIKQSSQFVK QLDGPDRLTC LFQIKRLLGL CCRLLQNCND DSLNVALPMR MLEVFSSENT
     YLPVLQDVSY VTSLIEQILH YMIQKGYYKS LYLLINNKLP SSIEYSDVSR VPIAKILLEN
     VLKPLHFTYS SCPEGARQQI FAAFTEEFLA APFTDQIFHF IIPALADVQT VFPYELFLNA
     LLLAESGCSR RSDQAPWLFY FVLTVGETYL GSLSEEGLLV YLRVLQTFLS QLPVSAAGTN
     CQDANSDSED EDEEISKMTT APGDGRISVQ YITEECLKKL DTKQQTNTLL NMVWRDSASE
     EVFTLMASIC HTLMVQHRMM VPKVLLYSLA FNARFLRHLW YLISSRTTRM ITGSMVPLLQ
     VISRGSPMSL EDSSRIIPLF YLFSSLFSHS LISIHDNEFF GDPIEVVGQR QSSMMPFTLE
     ELVILSRCLR DACLGIIKLA YPETKPEVRE EYIAAFRSVG VTKNTEMQQC IQTEQKRWIQ
     LFKVITNLVK MLKSRDTRRN FCPPNHWLSE QENIKADKVT QLYVPSARHV WRVRRMGRIG
     PLQSTLDVGL EPAPLSVSEE RQLAILTELP FVVPFEERVK IFQRLIYADK QEVQGDGPFL
     DGINVTIRRN YIYEDAYDKL SPENEPDLKK RIRVHLLNAH GLDEAGIDGG GIFREFLNEL
     LKSGFNPNQG FFKTTNEGLL YPNPAAQMLV GDSYARHYYF LGRMLGKALY ENMLVELPFA
     SFFLSKLLGT SADVDIHHLA SLDPEMYKNL LFLKSYEGDV EELGLNFTVV NNDLGEAQVV
     ELKPGGKDIP VTSANRIAYI HLVADYRLNK QIRQHCLAFR QGLANVVNLE WLRMFDQQEI
     QVLISGAQVP ISLDDLKSFT NYSGGYTADH PVIKIFWRVV ESFTDEEKRK LLKFVTSCSR
     PPLLGFKELY PAFCIHNGGS DLDRLPTAST CMNLLKLPEF YDENLMRSKL LYAIECAAGF
     ELS
//