ID A0A091PMR0_HALAL Unreviewed; 772 AA.
AC A0A091PMR0;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE SubName: Full=Guanine nucleotide exchange factor VAV2 {ECO:0000313|EMBL:KFP95903.1};
DE Flags: Fragment;
GN ORFNames=N329_12820 {ECO:0000313|EMBL:KFP95903.1};
OS Haliaeetus albicilla (White-tailed sea-eagle) (Falco albicilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Accipitriformes; Accipitridae;
OC Accipitrinae; Haliaeetus.
OX NCBI_TaxID=8969 {ECO:0000313|EMBL:KFP95903.1, ECO:0000313|Proteomes:UP000054379};
RN [1] {ECO:0000313|EMBL:KFP95903.1, ECO:0000313|Proteomes:UP000054379}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N329 {ECO:0000313|EMBL:KFP95903.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KK640710; KFP95903.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091PMR0; -.
DR Proteomes; UP000054379; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd20868; C1_VAV2; 1.
DR CDD; cd01223; PH_Vav; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd10406; SH2_Vav2; 1.
DR CDD; cd11980; SH3_VAV2_1; 1.
DR CDD; cd11977; SH3_VAV2_2; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR037832; PH_Vav.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR035880; VAV2_SH2.
DR InterPro; IPR035733; VAV2_SH3_1.
DR InterPro; IPR035732; VAV2_SH3_2.
DR PANTHER; PTHR45818:SF4; GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV2; 1.
DR PANTHER; PTHR45818; PROTEIN VAV; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF07653; SH3_2; 2.
DR PRINTS; PR00401; SH2DOMAIN.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00109; C1; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50890; PUA; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50002; SH3; 2.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000054379};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 1..52
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 126..304
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 333..435
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 446..495
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 509..575
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 596..690
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 710..771
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFP95903.1"
FT NON_TER 772
FT /evidence="ECO:0000313|EMBL:KFP95903.1"
SQ SEQUENCE 772 AA; 89793 MW; ACD1B6044F3BEEB1 CRC64;
QFLCLKNIRT FLKVCHDKFG LRNSDLFDPF DLFDVRDFGK VISAVSRLSF HSIAQTKGIR
PFPSEETTEN DDDVYRSLEE LADEHDLGED IYDCVPCEDE GDDIYEDIIR VEVQQPMKMG
MTEDDKRNCC LLEIQETEAK YYKTLEDIEK NYMNPLRLVL TPQDMEAIFI NLEDLIKVHF
SFLRAIDVSM MSGGSSLAKV FLEFKERLLI YGKYCSHMEY AQNTLNHLLT NREDVRQKVE
ECTLKVQDGK FKLQDLLVVP MQRVLKYHLL LKELLSHSSD RPEKQQLKEA LEAMQDLAMY
INEVKRDKET LKKISEFQSS IENLQVKLEE FGRPKIDGEL KVRSIVNHTK QDRYLFLFDK
VVIVCKRKGY NYELKEIIEL LFHKMTDDPM NNKDIKKWSY GFYLIHLQGK QGFQFFCKTE
EMKRKWMEQF EMAMSNIKPE KANANHHNFQ MYTFEKTTNC KACRMFLRGT FYQGYLCPKC
GAGAHKECLE IIPPCKIGSS ADQDSLSAGP GPKMVVVQNY HGNPAPPGKP VLTFQIGDVV
ELLRGDPDSP WWEGRLLQTK KSGYFPSSSV KPCPVDARPP NSRPPSREID YTAYPWFAGN
MERQQTDNLL KSHVSGTYLI RERPAEAERF AISIKFNEEV KHIKVVEKDN WIHITEAKKF
ESLLELVEYY QSHSLKESFK QLDTTLKYPY KSRERSTSRT FTRSPVFTPR VIGTAVARYN
FAARDMRELS LREGDVVKIY SRIGGDQGWW KGETNGRVGW FPSTYVEEEG VQ
//