ID A0A091PUM6_HALAL Unreviewed; 633 AA.
AC A0A091PUM6;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=Acetoacetyl-CoA synthetase {ECO:0000256|ARBA:ARBA00015326, ECO:0000256|RuleBase:RU367019};
DE EC=6.2.1.16 {ECO:0000256|ARBA:ARBA00012988, ECO:0000256|RuleBase:RU367019};
DE Flags: Fragment;
GN ORFNames=N329_11703 {ECO:0000313|EMBL:KFQ11365.1};
OS Haliaeetus albicilla (White-tailed sea-eagle) (Falco albicilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Accipitriformes; Accipitridae;
OC Accipitrinae; Haliaeetus.
OX NCBI_TaxID=8969 {ECO:0000313|EMBL:KFQ11365.1, ECO:0000313|Proteomes:UP000054379};
RN [1] {ECO:0000313|EMBL:KFQ11365.1, ECO:0000313|Proteomes:UP000054379}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N329 {ECO:0000313|EMBL:KFQ11365.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Converts acetoacetate to acetoacetyl-CoA in the cytosol.
CC {ECO:0000256|RuleBase:RU367019}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP +
CC diphosphate; Xref=Rhea:RHEA:16117, ChEBI:CHEBI:13705,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57286,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:456215; EC=6.2.1.16;
CC Evidence={ECO:0000256|RuleBase:RU367019};
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|RuleBase:RU367019}.
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432, ECO:0000256|RuleBase:RU367019}.
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DR EMBL; KK666009; KFQ11365.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091PUM6; -.
DR Proteomes; UP000054379; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0030729; F:acetoacetate-CoA ligase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd05943; AACS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR005914; Acac_CoA_synth.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR NCBIfam; TIGR01217; ac_ac_CoA_syn; 1.
DR PANTHER; PTHR42921; ACETOACETYL-COA SYNTHETASE; 1.
DR PANTHER; PTHR42921:SF1; ACETOACETYL-COA SYNTHETASE; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU367019};
KW Cytoplasm {ECO:0000256|RuleBase:RU367019};
KW Fatty acid metabolism {ECO:0000256|RuleBase:RU367019};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU367019};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098,
KW ECO:0000256|RuleBase:RU367019};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU367019};
KW Reference proteome {ECO:0000313|Proteomes:UP000054379}.
FT DOMAIN 6..63
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 69..451
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ11365.1"
FT NON_TER 633
FT /evidence="ECO:0000313|EMBL:KFQ11365.1"
SQ SEQUENCE 633 AA; 70452 MW; AF4906CDBCD00836 CRC64;
LLLANYDDLY QWSVESFSDF WAEFWKYSNI TCSRLYDEVV DTSKSIADVP EWFKGSRLNY
AENLLKHKDN DKIALYAAKE GKEEILKITF EELRQAVALY AAAMRKMGVK VGDRVVGYLP
NSIHAVEAML AAASIGAIWS STSPDFGING VLDRFSQIQP KLIFSVEAVI YNGKEHNHLE
KLLSVVKGLP DIRKVVVIPY VSSRETVDIS KIPNSVFLED FLATGKGDQA PQLEFEQLPF
SHPLFIMYSS GTTGAPKCMV HSAGGTLIQH LKEHILHGNM TSNDIIMYYT TASTGWMMWN
WLVTALATGA SVVLYDGSPL IPSPNVLWDL TDRLGITILG TGAKWLAVLE EKNLKPCETH
NLQTLHTILS TGSPLKSQSY EYVYKHIKSS VLLGSISGGT DIISCFMGQN VTIPVYKGEI
QARNLGMAVE AWNDEGKPVW GESGELVCTK PIPCQPTHFW NDENGSKYRK AYFSKFPGVW
AHGDYCKINP KTGGIVMLGR SDGTLNPNGV RFGSSEIYNI VEAFEEVSDS LCVPQYNKDG
EERVILFLKM ALNHAFSEDL VKRIRDAIRI ALSARHVPSL ILETKGIPYT VNGKKVEVAV
KQIIAGKEVE QRGAFSNPET LDLYQNIPEL QNF
//
