ID A0A091Q3B0_LEPDC Unreviewed; 1067 AA.
AC A0A091Q3B0;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 03-MAY-2023, entry version 28.
DE SubName: Full=Retinoblastoma-like 2 {ECO:0000313|EMBL:KFQ14677.1};
DE Flags: Fragment;
GN ORFNames=N330_07465 {ECO:0000313|EMBL:KFQ14677.1};
OS Leptosomus discolor (Madagascar cuckoo roller) (Cuculus discolor).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Coraciiformes; Leptosomidae; Leptosomus.
OX NCBI_TaxID=188344 {ECO:0000313|EMBL:KFQ14677.1, ECO:0000313|Proteomes:UP000053001};
RN [1] {ECO:0000313|EMBL:KFQ14677.1, ECO:0000313|Proteomes:UP000053001}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N330 {ECO:0000313|EMBL:KFQ14677.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the retinoblastoma protein (RB) family.
CC {ECO:0000256|ARBA:ARBA00009475}.
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DR EMBL; KK686182; KFQ14677.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091Q3B0; -.
DR PhylomeDB; A0A091Q3B0; -.
DR Proteomes; UP000053001; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd20606; CYCLIN_RBL2; 1.
DR Gene3D; 1.10.472.140; -; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 2.
DR InterPro; IPR013763; Cyclin-like_dom.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR002720; RB_A.
DR InterPro; IPR002719; RB_B.
DR InterPro; IPR015030; RB_C.
DR InterPro; IPR028309; RB_fam.
DR InterPro; IPR024599; RB_N.
DR PANTHER; PTHR13742; RETINOBLASTOMA-ASSOCIATED PROTEIN RB -RELATED; 1.
DR PANTHER; PTHR13742:SF8; RETINOBLASTOMA-LIKE PROTEIN 2; 1.
DR Pfam; PF11934; DUF3452; 1.
DR Pfam; PF01858; RB_A; 1.
DR Pfam; PF01857; RB_B; 1.
DR SMART; SM00385; CYCLIN; 1.
DR SMART; SM01367; DUF3452; 1.
DR SMART; SM01368; RB_A; 1.
DR SMART; SM01369; Rb_C; 1.
DR SUPFAM; SSF47954; Cyclin-like; 3.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000053001};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 21..163
FT /note="Retinoblastoma-associated protein N-terminal"
FT /evidence="ECO:0000259|SMART:SM01367"
FT DOMAIN 341..533
FT /note="Retinoblastoma-associated protein A-box"
FT /evidence="ECO:0000259|SMART:SM01368"
FT DOMAIN 772..941
FT /note="Cyclin-like"
FT /evidence="ECO:0000259|SMART:SM00385"
FT DOMAIN 948..1067
FT /note="Retinoblastoma-associated protein C-terminal"
FT /evidence="ECO:0000259|SMART:SM01369"
FT REGION 578..603
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 857..928
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 582..603
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 878..892
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ14677.1"
FT NON_TER 1067
FT /evidence="ECO:0000313|EMBL:KFQ14677.1"
SQ SEQUENCE 1067 AA; 121307 MW; 6695982EA3EC1984 CRC64;
FNSQGNDLHW LACALYVACR KAIPTVSRGT AEGNYVSLTR ILRCSEQSLI EFFNKMKKWE
DMANLPSQFR ERTERLERNF TVSAVIFKKY EPIFQDIFRY PQEDQPRQQR GRKQRRQPCT
VTEVFQFCWV LFVHAKGNFP MISDDLVNSY HLLLCALDLV YGNALQCPNR KELLNPNFKG
LPEDFNSKDY KVSSDPPCII EKLCSLHYGL VLEAKGIKEH FWKPYIRKLF DKKLLKGKDE
NLTGFLDPGN FGDSFKAINK AYEEYVLSVG NLDERIFLGE DADEEIGTLT RCLNTTSGME
TAERVQVKHN LQQHFDRSKS LRITTPLTGR KYIKESNPYV TPVSIATYSL SRLHTMLTGL
KNAPSDNLEQ ILRACSRDPS QSIANRVKEM YEAYCQSVQS EGEFSNVSKD VASKHFRRAE
VLYYKVLESV IEQERRRLGD ADLSAILEQD VFHRSLLACC LEIITFTYKP PGNFPFITEI
FDIPVYHFYK VIEVLIRAED GLCREVVKHL NHIEEQILES MAWKQESILW DRIRDNENKV
PSCEEVMPPQ YFERCAGNSV IGSPLTPRRI TEVRAETGGL GKGLSSSPTT LYDRYSSPTA
NPTRRRLFVD NDNTSDSGTP VRVSQQPVVN TVPVQNMNPE AMSVTPVPGQ TLVTVATATV
TANNGQTVTI PVQGIANENG GITFFPVQVN VGTQPQTVSA PIQPLSAQTL AGTLNPQMTG
ATLQLPGQLT VQQISPGEQR PTQQFTTATS IRPRKMGSLA LFFRKVYHLA SVRLRDLCVK
LDIADELRKK IWTCFEYSLV HCPEIMMDRH LDQLLMCAIY VMAKVTKEDR SFQNIMRCYR
TQPQAKSHVY RSVLIKGRRR RRRSGSSDSS SQQSSPTDRS KERNKEKTSR DSSPVMRSSS
TLPVPHPNSA PPTPTRLMGA NSDTEEEERG DLIQFYNNIY IEQIKEFALK YTSNAQADSP
PLSPYPFVRM GSPRRIQLSQ NHPVYISPHK SESTLSPREK IFYYFSSSPS KRLKEINSMV
RTGETPTKKR GILLEDGTEA PAKRICQENH TALLRRLQDV ANDRGSH
//
