ID A0A091Q5S0_LEPDC Unreviewed; 749 AA.
AC A0A091Q5S0;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 13-SEP-2023, entry version 30.
DE RecName: Full=Chloride anion exchanger {ECO:0000256|RuleBase:RU362052};
DE AltName: Full=Solute carrier family 26 member 3 {ECO:0000256|RuleBase:RU362052};
DE Flags: Fragment;
GN ORFNames=N330_11251 {ECO:0000313|EMBL:KFQ15265.1};
OS Leptosomus discolor (Madagascar cuckoo roller) (Cuculus discolor).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Coraciiformes; Leptosomidae; Leptosomus.
OX NCBI_TaxID=188344 {ECO:0000313|EMBL:KFQ15265.1, ECO:0000313|Proteomes:UP000053001};
RN [1] {ECO:0000313|EMBL:KFQ15265.1, ECO:0000313|Proteomes:UP000053001}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N330 {ECO:0000313|EMBL:KFQ15265.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mediates chloride-bicarbonate exchange with a chloride
CC bicarbonate stoichiometry of 2:1 in the intestinal epithelia. Plays a
CC role in the chloride and bicarbonate homeostasis during sperm
CC epididymal maturation and capacitation.
CC {ECO:0000256|RuleBase:RU362052}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000256|RuleBase:RU362052}.
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DR EMBL; KK687689; KFQ15265.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091Q5S0; -.
DR PhylomeDB; A0A091Q5S0; -.
DR Proteomes; UP000053001; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
DR CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR Gene3D; 3.30.750.24; STAS domain; 1.
DR InterPro; IPR018045; S04_transporter_CS.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR NCBIfam; TIGR00815; sulP; 1.
DR PANTHER; PTHR11814:SF19; CHLORIDE ANION EXCHANGER; 1.
DR PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SUPFAM; SSF52091; SpoIIaa-like; 1.
DR PROSITE; PS01130; SLC26A; 1.
DR PROSITE; PS50801; STAS; 1.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|RuleBase:RU362052};
KW Chloride {ECO:0000256|RuleBase:RU362052};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW Reference proteome {ECO:0000313|Proteomes:UP000053001};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362052};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362052}; Transport {ECO:0000256|RuleBase:RU362052}.
FT TRANSMEM 77..98
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 104..120
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 127..146
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 166..186
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 193..213
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 249..268
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 280..297
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 334..353
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 365..382
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 402..423
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 460..487
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT DOMAIN 515..710
FT /note="STAS"
FT /evidence="ECO:0000259|PROSITE:PS50801"
FT NON_TER 749
FT /evidence="ECO:0000313|EMBL:KFQ15265.1"
SQ SEQUENCE 749 AA; 82821 MW; 9F1CE99925BE03A2 CRC64;
MVEPVGNHYV VARPVYSENL FNEEHEKLHR YHKTFWDHLK LYFRCSPQRA KKIALRLFPI
VSWLPAYRFR EWILSDIVSG INTGLVAVLQ GLAFALLVNV PPGYGLYAAF FPVLVYFIFG
TSRHISVGPF PVLSLMVGGT VVRLVPDDSA GNGTSTNISA INEERVMVAA SVTFLSGVFQ
LLLGILQFGF IVIYLSQSLI SGFTTAAAIH VLVSQLKFML QLPVPGFNKP FGIIYTLESV
FSQITETNIA DLVTSLVVLL IVFVVKEIND RYKAKLPTPI PIELLVTVLA ALISYFVNFE
EKFGVAVVGK LEEGFQVPVA PDAGILQKCI GDSISIAIVG FAVAFSVAKV YSIKHDYPVD
GNQELIAFGL GNIVGGSFKG FASSTALSRS GVQESTGGKT QIAGIISAVI VLIVILAIGF
LLAPLQKSVL ASLALGNLKG MLMQFKEIGI LWRKDKYDCI IWVVTFLAAV FLGLDIGLAT
AVAFQLLTVV IRSQIPSCTV LANVGRSNIY RNRKDYTDIY EPEGVKIFRC SSPIFFANIE
FFREKLITAV GFNPQRVLRK RNKALRKIRK MLKKGELQVT PVCLICAANH THESDEELDN
NRIEELDQPT NMTDLPIQIN WGADLPPGIT VPRVDIHSII LDFSSVSFLD FSAMRVLQKT
LKEFVRINID IYIAGAHEGF LDKLERCAFF DEEIKPSMFF LTIHDAVLHI LLKKDIASSP
KLKVTEEKCS SNNSIIISSN GLRSRECTV
//