ID A0A091Q7X2_LEPDC Unreviewed; 923 AA.
AC A0A091Q7X2;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE SubName: Full=Integrin alpha-4 {ECO:0000313|EMBL:KFQ16352.1};
DE Flags: Fragment;
GN ORFNames=N330_05750 {ECO:0000313|EMBL:KFQ16352.1};
OS Leptosomus discolor (Madagascar cuckoo roller) (Cuculus discolor).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Coraciiformes; Leptosomidae; Leptosomus.
OX NCBI_TaxID=188344 {ECO:0000313|EMBL:KFQ16352.1, ECO:0000313|Proteomes:UP000053001};
RN [1] {ECO:0000313|EMBL:KFQ16352.1, ECO:0000313|Proteomes:UP000053001}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N330 {ECO:0000313|EMBL:KFQ16352.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR EMBL; KK690327; KFQ16352.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091Q7X2; -.
DR PhylomeDB; A0A091Q7X2; -.
DR Proteomes; UP000053001; Unassembled WGS sequence.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF78; INTEGRIN ALPHA-4; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 4.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 4.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000053001};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT TRANSMEM 866..892
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 81..132
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 186..245
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 249..306
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 310..372
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 357..513
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 516..661
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 672..839
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ16352.1"
FT NON_TER 923
FT /evidence="ECO:0000313|EMBL:KFQ16352.1"
SQ SEQUENCE 923 AA; 102948 MW; 25E8224D08932B40 CRC64;
LGNPNGERCG KTCLEERDNQ WLGVSLSRQP KENGSIVACG HRWKNIFYIK NEHKLPYGIC
FAISSEFRTE LSRRICPCYI DHVRKFGENH GSCQAGMSSF YIEDLIILGA PGSFYWTGSV
FVYNTTANTI HAYTDSNNQV KFGSYLGYSV GAGHFLTSAS TEVIGGAPQQ EQTGKAYIFS
IEKQLNILFE LRGKKLGSYF GAAVCAVDLN SDGLSDLLVG APMQSTIREE GRVYVYINSG
SEAKMVELNI ELSGSDSYAA RFGESIANLG DIDNDGFEDV AIGAPQEDNL KGVIYIYNGR
KDGITPSFSQ RIQGLQVSNS LSMFGQSIAS GIDADNNGYQ DVAVGAFLSD SAVVLRTKPV
IIVEASLKHS NSVNRTNLNC MENDQPAVCM NLKICFSYTG REVPGYIVLL YNLSVDVNRK
VDTQGRFYFS SNGTSDTISG NVKIYSKNIA CKDHPAFMRK DVRDILTPVH VEASYHLGHH
VLQKRNAQEF SPLQPVLQQR KEKDVIKSKF VFARFCSQEN CSADLRVSGK VAFPKPHDKK
TYLAVGSMKT LLLNVSLLNV GDDAYETVLH IQIPKGLYFI RVLELEEKQI HCEVLDKENH
AVKLECSVGY LYVDQKSKLD FSFLLDASSF TRADDDLNII INATCKNEDG NMLLDNTLTL
YVPLKYEIEL NTHGFVSPAS FLYGTNEKDS SVACMKENIN FTFHVISAGP SMAPNTNLEI
MIPNAFPPHD FKLFNTLDIK TTVGQCSYNK YPRNCSAAER NENILKDVVT FFSKPAKRQM
YCMKNDSLCL QIHCELGNME SGKEATIQLQ LEATPSLLEM DDASALKFEV RATASPEKNA
RVIELHKDKQ TAYVYLEGVH HQKPKYHVTV LIIGIGLIVG VTLFLLLSFI LWKIGFFKRQ
YKPVPQDKNR RDSWSFTTGN KDD
//
