ID A0A091QA20_MERNU Unreviewed; 965 AA.
AC A0A091QA20;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Small G protein signaling modulator 2 {ECO:0000313|EMBL:KFQ21805.1};
DE Flags: Fragment;
GN ORFNames=N331_05710 {ECO:0000313|EMBL:KFQ21805.1};
OS Merops nubicus (Northern carmine bee-eater).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Coraciiformes; Meropidae; Merops.
OX NCBI_TaxID=57421 {ECO:0000313|EMBL:KFQ21805.1, ECO:0000313|Proteomes:UP000052967};
RN [1] {ECO:0000313|EMBL:KFQ21805.1, ECO:0000313|Proteomes:UP000052967}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N331 {ECO:0000313|EMBL:KFQ21805.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the RUTBC family.
CC {ECO:0000256|ARBA:ARBA00034124}.
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DR EMBL; KK691513; KFQ21805.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091QA20; -.
DR Proteomes; UP000052967; Unassembled WGS sequence.
DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProt.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR CDD; cd15784; PH_RUTBC; 1.
DR CDD; cd17704; RUN_SGSM2; 1.
DR Gene3D; 1.20.58.900; -; 1.
DR Gene3D; 2.30.29.230; -; 1.
DR Gene3D; 1.10.8.270; putative rabgap domain of human tbc1 domain family member 14 like domains; 1.
DR Gene3D; 1.10.472.80; Ypt/Rab-GAP domain of gyp1p, domain 3; 1.
DR InterPro; IPR000195; Rab-GAP-TBC_dom.
DR InterPro; IPR035969; Rab-GAP_TBC_sf.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR InterPro; IPR047345; RUN_SGSM2.
DR InterPro; IPR037745; SGSM1/2.
DR InterPro; IPR021935; SGSM1/2_RBD.
DR PANTHER; PTHR22957:SF194; SMALL G PROTEIN SIGNALING MODULATOR 2; 1.
DR PANTHER; PTHR22957; TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF12068; PH_RBD; 1.
DR Pfam; PF00566; RabGAP-TBC; 1.
DR Pfam; PF02759; RUN; 1.
DR SMART; SM00593; RUN; 1.
DR SMART; SM00164; TBC; 1.
DR SUPFAM; SSF140741; RUN domain-like; 1.
DR SUPFAM; SSF47923; Ypt/Rab-GAP domain of gyp1p; 2.
DR PROSITE; PS50826; RUN; 1.
DR PROSITE; PS50086; TBC_RABGAP; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000052967}.
FT DOMAIN 16..173
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT DOMAIN 548..927
FT /note="Rab-GAP TBC"
FT /evidence="ECO:0000259|PROSITE:PS50086"
FT REGION 78..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 190..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 647..693
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 712..733
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 678..693
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ21805.1"
FT NON_TER 965
FT /evidence="ECO:0000313|EMBL:KFQ21805.1"
SQ SEQUENCE 965 AA; 108870 MW; EA611931893DA63A CRC64;
QVKQIMEEAV TRKFVHEDSS HIIALCGAVE ASLLHMLRRR AAGFLRTDKV AALFTKVGKT
YAVAGDICRR VQELQQQVES RKNQPNGQEP LKRQGSTTSK APVLTPQAIK HIWVRTALIE
KVLDKIVQYI VDNCSKYYEK EALLADPVCG PILASLLVGP CALEYTKLKT ADHYWTDPSA
DELVQRHRIH GAHGRQDSPS KRPALGVRKR HSSGGAEDRG AAAAREYVES LHQNSRTHLL
YGKNNVLVQP KDDLEAIPGY LSLHQSADSL TLKWTPNQLM NGTLGDSELE KSVFWDYALI
VPLSQIVCIH CHQQAESRWT LVLVSQDGTQ RPPLHFPQGG HLLAFLSCLE NGLLPRGQLE
PPLWSQQGKG KVFPKLRKRN SNKSVELEEM SAEDTSTDYV FRIIYPGHRH DNNTSEMIEM
QGFGANLLSW QLEHCSQGSS CLSCSTGSSP YDIPSCCSSI HDRTPLKMLC ESMKRQIVSR
AFYGWLAYCR HLSTVRTHLS ALVNHTIVPP DRPSSATGGL TKELWSKYQK DKKNYKELEL
LRRVYYGGVQ HEIRKEVWPF LLGHYKFGMA KKEMDQVDED VALRYQKVMA EWKACEVVVK
QREKESHSAT LAKFSSGSSI DSHVQRLIHR DSTISNDVFI SVDEADPVEQ GPRGQDDPPL
TLLAADTPGG AAAEQQSVEF DSPDSGLPSS RNYSVASGVL SSIDDGQSVS FEDGAEEEAG
PDVERTDADA PRVPKAKPAV LQAQEPPAAE QLCPQADDLM DVASVCAASY TIELLDTVAL
NLHRIDKDVQ RCDRNYWYFT ADNLEKLRNV MCSYVWEHLE VGYVQGMCDL LAPLMVILDN
DQLAYSCFSH LMKRMSQNFP NGGAMDTHFA NMRSLIQILD SELFELMHQN GDYTHFYFCY
RWFLLDFKRE LLYEDVFTVW EVIWAAKHIS SEHFVLFIAL ALVEVYREII RDNNMDFTDI
IKFFN
//
