ID A0A091QDU1_MERNU Unreviewed; 1026 AA.
AC A0A091QDU1;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Toll-like receptor 7 {ECO:0000313|EMBL:KFQ25094.1};
DE Flags: Fragment;
GN ORFNames=N331_00686 {ECO:0000313|EMBL:KFQ25094.1};
OS Merops nubicus (Northern carmine bee-eater).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Coraciiformes; Meropidae; Merops.
OX NCBI_TaxID=57421 {ECO:0000313|EMBL:KFQ25094.1, ECO:0000313|Proteomes:UP000052967};
RN [1] {ECO:0000313|EMBL:KFQ25094.1, ECO:0000313|Proteomes:UP000052967}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N331 {ECO:0000313|EMBL:KFQ25094.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, phagosome
CC {ECO:0000256|ARBA:ARBA00004262}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004115}. Lysosome
CC {ECO:0000256|ARBA:ARBA00004371}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR EMBL; KK697219; KFQ25094.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091QDU1; -.
DR Proteomes; UP000052967; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0045335; C:phagocytic vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0002218; P:activation of innate immune response; IEA:UniProt.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0060255; P:regulation of macromolecule metabolic process; IEA:UniProt.
DR GO; GO:0051171; P:regulation of nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0080090; P:regulation of primary metabolic process; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR041283; LRR_12.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR47410:SF2; TOLL-LIKE RECEPTOR 7; 1.
DR PANTHER; PTHR47410; TOLL-LIKE RECEPTOR 7-RELATED; 1.
DR Pfam; PF18837; LRR_12; 1.
DR Pfam; PF13855; LRR_8; 4.
DR Pfam; PF01582; TIR; 1.
DR SMART; SM00365; LRR_SD22; 9.
DR SMART; SM00369; LRR_TYP; 13.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 3.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:KFQ25094.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000052967};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 817..841
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 866..1010
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ25094.1"
FT NON_TER 1026
FT /evidence="ECO:0000313|EMBL:KFQ25094.1"
SQ SEQUENCE 1026 AA; 118612 MW; 6B9E50662D9D7732 CRC64;
LLSESWFHKS LPCDVKASED TVTVDCTDRR LIEVPRGIPE NATNLTLSIN HIPHIYPTTF
AHLENLMEID FRCNCVPVRM GPKDNVCNRR LKIENGSFAS LTRLKSLYLD ANQLLEIPRG
LPTTLSLLSL EANSIFSIQK ANLSELGNIE VLYLGQNCYY RNPCNVSFEI ERTAFLELKK
LTILSLKSNN LTHIPLNLPS TLKELYIYNN MIQVIQEYDL STLHNVEILD LSGNCPRCYN
APYPCIPCPR NTIEIHPNAF YSLKNLRILR LHSNSLQSIP SRWFKTIKNL KELDLSQNFL
MKEIGDAQFL KFIPSLVELD LSFNFEVKTY SPYLNLSKTF SSLSNLETLR VKGYVFKELR
RRDLNPLLSL RNLTVLDLGT NFIKVADLRA FNEFPALKLI DLSMNKISPS SDESNLYGFC
SNSRISVEQY NREVLQEMHY FRYDEYGRSC RSKDKEAASY QSPVKEECRE YGETLDLSRN
NVFFINPSDF RDLSSLRCLN LSGNAISQTL NGSEFYYMSG LKYLDFSNNR IDLLYSTAFK
ELQSLEILDL SNNEHYFLAE GVTHVLSFVK NLAHLKKLMM NENAISTSIN TGMESQSLQI
LEFRGNRLDV LWMDGNARYL SFFKNLTSLE QLDISFNSLS FFPHGVFDAM PPELKVLNLT
NNQMKSFNWG NLHYMKKLVT LDLSNNLLAT VPRELSNCSS TLQELMLRNN RIQRLTKHFL
RDAFTLKYLD LSSNKIQIIK KSSFPENVIN NLRMLLLHGN PFKCNCDAVW FVWWINQTQV
TIPLLATDVT CAGPGAHKGR SVVFLDLYTC ELDTSYLILY ALSASTVLGL MVFAVMSHLY
FWDVWYSYHY CTAKLKGYRR LSLPDACYDA FVAYDNEDPA VNEWVLRELV ERLENQRAKR
FNLCLEDRDW VPGQPVFDNL SQSIQLSKKT VFVLTSKYIK SGSFKTTFYM AHQRLLDEKM
DVIILIFLER VLQKSRYVRL RKRLCRSSVL EWPTNPRSQP YFWQCLKNAI ATSNTLAYNK
LLQETV
//
