ID A0A091QG21_MERNU Unreviewed; 281 AA.
AC A0A091QG21;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=TGF-beta family profile domain-containing protein {ECO:0000259|PROSITE:PS51362};
DE Flags: Fragment;
GN ORFNames=N331_07656 {ECO:0000313|EMBL:KFQ25295.1};
OS Merops nubicus (Northern carmine bee-eater).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Coraciiformes; Meropidae; Merops.
OX NCBI_TaxID=57421 {ECO:0000313|EMBL:KFQ25295.1, ECO:0000313|Proteomes:UP000052967};
RN [1] {ECO:0000313|EMBL:KFQ25295.1, ECO:0000313|Proteomes:UP000052967}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N331 {ECO:0000313|EMBL:KFQ25295.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR EMBL; KK697565; KFQ25295.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091QG21; -.
DR Proteomes; UP000052967; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0051216; P:cartilage development; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0001503; P:ossification; IEA:UniProtKB-KW.
DR CDD; cd19390; TGF_beta_BMP2; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR047953; BMP2_TGF_beta-like.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR NCBIfam; NF033679; DNRLRE_dom; 1.
DR PANTHER; PTHR11848:SF143; BONE MORPHOGENETIC PROTEIN 2; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR PRINTS; PR00669; INHIBINA.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Chondrogenesis {ECO:0000256|ARBA:ARBA00023188};
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Osteogenesis {ECO:0000256|ARBA:ARBA00022855};
KW Reference proteome {ECO:0000313|Proteomes:UP000052967};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 164..281
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 156..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..176
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ25295.1"
FT NON_TER 281
FT /evidence="ECO:0000313|EMBL:KFQ25295.1"
SQ SEQUENCE 281 AA; 32231 MW; F7647659EFCA3793 CRC64;
EVLEELPETS GKTARRFFFN LTSIPNEESI TSAELQIFRK QVHGAFENNS SYHHRINIYE
IIKPATATSK DPVTRLLDTR LVHHNASKWE SFDVTPAVLR WIAHGQPNHG FVVEVVHLDK
ENSASKRHVR ISRSLHQDED SWSQLRPLLV TFGHDGKGHP LHKREKRQAK HKQRKRHKYS
CKRHPLYVDF NDVGWNDWIV APPGYSAFYC HGECPFPLAD HLNSTNHAIV QTLVNSVNSK
IPKACCVPTE LSAISMLYLD ENEKVVLKNY QDMVVEGCGC R
//
