ID   A0A091QJQ7_MERNU        Unreviewed;       605 AA.
AC   A0A091QJQ7;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=Neurolysin, mitochondrial {ECO:0000256|ARBA:ARBA00039454};
DE            EC=3.4.24.16 {ECO:0000256|ARBA:ARBA00039068};
DE   AltName: Full=Microsomal endopeptidase {ECO:0000256|ARBA:ARBA00041940};
DE   AltName: Full=Mitochondrial oligopeptidase M {ECO:0000256|ARBA:ARBA00042607};
DE   AltName: Full=Neurotensin endopeptidase {ECO:0000256|ARBA:ARBA00041659};
DE   Flags: Fragment;
GN   ORFNames=N331_01532 {ECO:0000313|EMBL:KFQ27413.1};
OS   Merops nubicus (Northern carmine bee-eater).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Coraciiformes; Meropidae; Merops.
OX   NCBI_TaxID=57421 {ECO:0000313|EMBL:KFQ27413.1, ECO:0000313|Proteomes:UP000052967};
RN   [1] {ECO:0000313|EMBL:KFQ27413.1, ECO:0000313|Proteomes:UP000052967}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N331 {ECO:0000313|EMBL:KFQ27413.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Preferential cleavage in neurotensin: 10-Pro-|-Tyr-11.;
CC         EC=3.4.24.16; Evidence={ECO:0000256|ARBA:ARBA00035987};
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|RuleBase:RU003435};
CC       Note=Binds 1 zinc ion. {ECO:0000256|RuleBase:RU003435};
CC   -!- SIMILARITY: Belongs to the peptidase M3 family.
CC       {ECO:0000256|ARBA:ARBA00006040, ECO:0000256|RuleBase:RU003435}.
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DR   EMBL; KK701267; KFQ27413.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A091QJQ7; -.
DR   MEROPS; M03.002; -.
DR   Proteomes; UP000052967; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd06455; M3A_TOP; 1.
DR   Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR   Gene3D; 1.10.1370.10; Neurolysin, domain 3; 1.
DR   InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR   InterPro; IPR024077; Neurolysin/TOP_dom2.
DR   InterPro; IPR024080; Neurolysin/TOP_N.
DR   InterPro; IPR045090; Pept_M3A_M3B.
DR   InterPro; IPR001567; Pept_M3A_M3B_dom.
DR   PANTHER; PTHR11804:SF44; NEUROLYSIN, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR11804; PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED; 1.
DR   Pfam; PF01432; Peptidase_M3; 1.
DR   SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU003435};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU003435};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049,
KW   ECO:0000256|RuleBase:RU003435};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|RuleBase:RU003435};
KW   Reference proteome {ECO:0000313|Proteomes:UP000052967};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU003435}.
FT   DOMAIN          152..600
FT                   /note="Peptidase M3A/M3B catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF01432"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFQ27413.1"
FT   NON_TER         605
FT                   /evidence="ECO:0000313|EMBL:KFQ27413.1"
SQ   SEQUENCE   605 AA;  69708 MW;  B65A05C800532F87 CRC64;
     TVERSMLDFP QHVSPDKEVR LASTEADKKL SNFDVEMSMR EDVFQKIVYL QQTSDLENVK
     PETKRYLEKS VQVGKRNGLH LPEEVQNEIK TMKKKLSELC IDFNKNLNEE NTFLIFSNEE
     LEGLPDDFIK SLEKTEEDKY KVTLKYPHYF PVMKKCCISE TRRKMETAFN SRCKEENTKI
     LRQLLPLRAR VAELLGYNTH ANFVLEVNTA KSTDNVTAFL DDLSKKLKPL AEEEREFILE
     LKKKECKEKK FYYDGRINAW DLHYYMNKTE ELKYSIDQEN LKEYFPIQAV TEGLLNIYQK
     LLGLVFEQVE SAHVWHDSVT LYTVKDNSTG EMLGQFYLDL YPREGKYGHA ACFGLQPGCL
     LSNGSRMMSV AALVTNFTKP ASDSPSLLRH DEVKTYFHEF GHVMHQICAQ TDFARFSGTN
     VETDFVEVPS QMFENWVWEK EPLQQMSRHY KDQSHVGDTL LEKLAASRLA NTGLLTLRQI
     VLSKVDQALH TKPSVDPADE YAKYCMEILG IPATPGTNMP ATFGHLAGGY DAQYYGYLWS
     EVFSMDIFYS CFKQEGIMNP KAGMKYRSLI LKPGGSLDGM DMLQNFLERK PSQRAFLLSK
     GLSVQ
//