ID A0A091QRL3_HALAL Unreviewed; 269 AA.
AC A0A091QRL3;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Platelet-derived growth factor D {ECO:0000256|ARBA:ARBA00018876};
DE Flags: Fragment;
GN ORFNames=N329_01956 {ECO:0000313|EMBL:KFQ12039.1};
OS Haliaeetus albicilla (White-tailed sea-eagle) (Falco albicilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Accipitriformes; Accipitridae;
OC Accipitrinae; Haliaeetus.
OX NCBI_TaxID=8969 {ECO:0000313|EMBL:KFQ12039.1, ECO:0000313|Proteomes:UP000054379};
RN [1] {ECO:0000313|EMBL:KFQ12039.1, ECO:0000313|Proteomes:UP000054379}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N329 {ECO:0000313|EMBL:KFQ12039.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Homodimer; disulfide-linked. Interacts with PDGFRB homodimers,
CC and with heterodimers formed by PDGFRA and PDGFRB.
CC {ECO:0000256|ARBA:ARBA00026039}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR EMBL; KK666883; KFQ12039.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091QRL3; -.
DR Proteomes; UP000054379; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IEA:InterPro.
DR CDD; cd00041; CUB; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR000072; PDGF/VEGF_dom.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR11633; PLATELET-DERIVED GROWTH FACTOR; 1.
DR PANTHER; PTHR11633:SF4; PLATELET-DERIVED GROWTH FACTOR D; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF00341; PDGF; 1.
DR SMART; SM00042; CUB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS50278; PDGF_2; 1.
PE 4: Predicted;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000054379}.
FT DOMAIN 1..118
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 195..243
FT /note="Platelet-derived growth factor (PDGF) family
FT profile"
FT /evidence="ECO:0000259|PROSITE:PS50278"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ12039.1"
FT NON_TER 269
FT /evidence="ECO:0000313|EMBL:KFQ12039.1"
SQ SEQUENCE 269 AA; 30750 MW; 566819496D981A6A CRC64;
EETISVAGNG CIHSPRFPSS YPRNLLLTWR LHSPESTRIQ LAFDNQFGLE EPENDICRYD
FVEVEDVSET STVIRGRWCG HKEVPPRITS RTNQIKITFK SDDYFVAKPG FKICYSLVVS
HLAVSWGVSY PSPSVTDPTL TAEALDQTIA AFDTVEDLLK HFNPDSWQED LENLYTDSGH
HYRGRSYHDR KSKVDLDRLN DDVKRYSCTP RNYSVNLREE LKLTNVVFFP RCLLVQRCGG
NCGCGTSNWK SCTCMSGKTV KKYHEVFSL
//
