ID A0A091QWE6_MERNU Unreviewed; 1834 AA.
AC A0A091QWE6;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=von Willebrand factor {ECO:0000256|ARBA:ARBA00016619};
DE Flags: Fragment;
GN ORFNames=N331_11585 {ECO:0000313|EMBL:KFQ31865.1};
OS Merops nubicus (Northern carmine bee-eater).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Coraciiformes; Meropidae; Merops.
OX NCBI_TaxID=57421 {ECO:0000313|EMBL:KFQ31865.1, ECO:0000313|Proteomes:UP000052967};
RN [1] {ECO:0000313|EMBL:KFQ31865.1, ECO:0000313|Proteomes:UP000052967}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N331 {ECO:0000313|EMBL:KFQ31865.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Multimeric. Interacts with F8.
CC {ECO:0000256|ARBA:ARBA00025858}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KK708497; KFQ31865.1; -; Genomic_DNA.
DR Proteomes; UP000052967; Unassembled WGS sequence.
DR GO; GO:0007596; P:blood coagulation; IEA:UniProtKB-KW.
DR CDD; cd19941; TIL; 4.
DR CDD; cd01450; vWFA_subfamily_ECM; 3.
DR Gene3D; 2.10.25.10; Laminin; 4.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 3.
DR InterPro; IPR036084; Ser_inhib-like_sf.
DR InterPro; IPR002919; TIL_dom.
DR InterPro; IPR032361; VWA_N2.
DR InterPro; IPR014853; VWF/SSPO/ZAN-like_Cys-rich_dom.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR001007; VWF_dom.
DR InterPro; IPR001846; VWF_type-D.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR11339; EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED; 1.
DR PANTHER; PTHR11339:SF361; VON WILLEBRAND FACTOR; 1.
DR Pfam; PF08742; C8; 3.
DR Pfam; PF01826; TIL; 3.
DR Pfam; PF00092; VWA; 3.
DR Pfam; PF16164; VWA_N2; 1.
DR Pfam; PF00094; VWD; 3.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00832; C8; 3.
DR SMART; SM00327; VWA; 3.
DR SMART; SM00215; VWC_out; 2.
DR SMART; SM00216; VWD; 2.
DR SUPFAM; SSF57567; Serine protease inhibitors; 4.
DR SUPFAM; SSF53300; vWA-like; 3.
DR PROSITE; PS50234; VWFA; 3.
DR PROSITE; PS51233; VWFD; 3.
PE 4: Predicted;
KW Blood coagulation {ECO:0000256|ARBA:ARBA00023084};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hemostasis {ECO:0000256|ARBA:ARBA00022696};
KW Reference proteome {ECO:0000313|Proteomes:UP000052967};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 209..383
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 688..855
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 1091..1267
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1312..1492
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1501..1682
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1759..1834
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ31865.1"
FT NON_TER 1834
FT /evidence="ECO:0000313|EMBL:KFQ31865.1"
SQ SEQUENCE 1834 AA; 203759 MW; E9BCB5E137117CA0 CRC64;
GTLVGNSYDF ANSWALHSEN KRCKRVQTPS NTCNISSDAA EKDVMETCQL LQTSLIFSRC
HHRVDPEPYI NLCERDICLC TQGMDCHCSV FLDYARSCAH EGVVLDGWPE ETSCRPRCPV
GMEYKECASP CAKTCQSLNI NEVCHGQCVD GCSCPEGKLL DGEDCIESSD CSCVHSGRHY
PPGFTISQDC NSCICRRGTW ICSNGECPGE CSVTGQSHFK TFDNKYFTFS GICHYLFAKD
CVENSFSVII ETVQCADDPD AVCTRSASVR IQDLDNSLIK MKHGGGISLN GQDIQIPLLQ
GALRIQRMTR TSVRLSYGED LQVDWDGRGE LLVKLSPVYS ERICGLCGNY NGNQGDDFLT
PSGMVEALLE DFGNSWKLNA DCQNLLKQDS DPCNLNPRLA KYAEDSCSVL MSSAFEPCHH
EVSPSPHVKN CRFDVCSCSN GKDCLCSAVA NYAAACARKN ILVQWREPDF CPMTCPEGQV
YQQCGTPCNQ TCRSLSYPDE DCDELCVEGC YCPPGHYLDE REQCVPKSHC SCYYDGEIFQ
PEDIFSDHYT MCYCENGFMH CSTNRAPGAF LPDVFADERP SARIKRSLTC RPPMERFICP
ANNPRAEGLE CAKTCQNYDL ECISHGCISG CLCPKGMVRH ENKCVALERC PCFHNGREYA
KGETVTNDCN TCVCHGRKWE CTKNTCDGTC TVVGTAHYLT FDGLKYKFPG NCQYVLVQDF
CRDDSGTFRI LISNEGCGFT GEKCTKRIVI LYESGEIELF NGNVNIKVPP KDDNDLEVLR
SGRYYIIFLG KNISVTWDLA MGVSVILKGN FKDQVCGLCG NFDGIQNNDL TSSNEHLEVD
PVDFGNSWKV NPYCADVEKE QTLVSPLCNG NIVKQMMVET SCSILSGELF EKCRKLVNPE
PYIDICMYDT CACESIGDCA CFCDAIAAYA HVCAQKGVPV HWRSPSLCPQ SCEDLNKQEL
DFQCEWRYNS CGPACPVTCQ HPQPLECPLQ CVEGCHVHCP AGKILDELSL DCVSPEDCPV
CAVGELKIPH GKRIVLNEDN PQHCQSCLCE GKNLTCVACE PVENILTLTT PAPEEDIELP
PSEYSCSKMM DLAFLMDGSN KLSEEDFEQL KTFITGMMKK LHISQKKIRV SILVYRAGPT
IYLGLKDIKT QSQMRKIVQG IKYTGDEVAS ATEVLKYTVF HVFGKAERTN AARIAVLFIA
SKSPGKLRNI LTALKNKKIA VVAVGIGPYV NVEQIKFIEK QSGDNRAFLM NNVLELMDNR
DLLIDHLCDL GPDESSLIQA TSTPTIASAL FPSWGLTAPP PLTEKPTSRR LDIAFIVEGS
DNVGEENFNI IKEFIERVIT RMRVGQEDIH VTVMQYSETV TLEYSFREIQ SKESIIEKVR
SIPYQGGKAT NTGNALDYIS THTFTTVNGG RQDVPHLVYM VSSNPSTDVI TRPPRNINVI
PIGITPNANI QELRKISHPN NPIILHSYNA LIEEAPELVL QSCCSHKLWT EIPELCNKPM
DVMFLLDGSS NIGASDFEEM KNFVRAFIES VEISNTSIHV SVLQYARENN IEIPWNTPQE
KENLIDLVLS IQQREQGPTR LGKAIDFVVQ NAMSESHGGR PGASKVAIVV VSGRSEDTVE
AAALAARMNR VSLFTIGVGN GYDEEQLRTL TGPSSANRIM KLQNFEDLPT MITLNSEFIK
KVCMDPVREC IDEDGNKKKP GDKWTLPDQC HTVTCFPGDY TVLESHQINC ERMPKPACHS
NLPAVKVEET CGCRWMCPCV CIGSSSRHIV TFDGLNFKLT GNCSYTLFQD LQHDVEVLLH
EGSCRATPKM NCMDSIEVKH HGTSVQLFSD MEVS
//
