ID   A0A091RSS3_NESNO        Unreviewed;       527 AA.
AC   A0A091RSS3;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   08-NOV-2023, entry version 32.
DE   SubName: Full=T-lymphoma invasion and metastasis-inducing protein 2 {ECO:0000313|EMBL:KFQ44826.1};
DE   Flags: Fragment;
GN   ORFNames=N333_12253 {ECO:0000313|EMBL:KFQ44826.1};
OS   Nestor notabilis (Kea).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Psittaciformes; Psittacidae; Nestor.
OX   NCBI_TaxID=176057 {ECO:0000313|EMBL:KFQ44826.1, ECO:0000313|Proteomes:UP000053840};
RN   [1] {ECO:0000313|EMBL:KFQ44826.1, ECO:0000313|Proteomes:UP000053840}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N333 {ECO:0000313|EMBL:KFQ44826.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; KK930317; KFQ44826.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A091RSS3; -.
DR   Proteomes; UP000053840; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd01255; PH2_Tiam1_2; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR001331; GDS_CDC24_CS.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR043537; Tiam1/Tiam2/Sif.
DR   PANTHER; PTHR46001:SF5; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR TIAM2; 1.
DR   PANTHER; PTHR46001; TIAM (MAMMALIAN TUMOR INVASION AND METASTASIS FACTOR) HOMOLOG; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS00741; DH_1; 1.
DR   PROSITE; PS50010; DH_2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000053840}.
FT   DOMAIN          1..114
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   REGION          338..370
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          388..407
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          412..447
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        421..447
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFQ44826.1"
FT   NON_TER         527
FT                   /evidence="ECO:0000313|EMBL:KFQ44826.1"
SQ   SEQUENCE   527 AA;  59876 MW;  033AC8E8E0ACF8CB CRC64;
     FQKLLFSLGG SFLYYADHFK LYSGFCANHI KVQKVLERAK TDSAFKAFLD ARNPTKQHSS
     TLESYLIKPV QRVLKYPLLL KELVSLTDNE SEEHYHLTEA LKAMEKVASH INEMQKIYED
     YGTVFDQLVA DQSGTEKEVT ELSMGELLMH STVSWLNPFP SLGKARKDLE LTVFVFKRAV
     ILVYKENYKL KKKMPTNVRA VHNYGDLDPF KFRWLIPLSA LQVRLGNTAG TENSCIWELI
     HTKSELEGRP ETIFQLCSSD CENKTNIVKV IRSILRENFR RHIKCELPLE KTSKDRLVPL
     KNRVPATAKL ASTRSLKVLK NSSSSEWNGD LGKGTFQDSD ECSLSSSTQS SSCHTTESIQ
     EPKNSSLDKH VQSCASDFSN ALVKESDILS DDDDDDDYRN LKKGSPTKDI EIQFQRLKIS
     EEPSTDSERD QAAENEEGDG FETGDMHEHP KLVRGHFCPV KRKVNSTKRN RGTLMAMQER
     HQSLDSHSDA ANLDLNSILE REFSVQSLTS VVNEDCFYEA AERHGKS
//