ID   A0A091S254_NESNO        Unreviewed;       472 AA.
AC   A0A091S254;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   RecName: Full=exo-alpha-sialidase {ECO:0000256|ARBA:ARBA00012733};
DE            EC=3.2.1.18 {ECO:0000256|ARBA:ARBA00012733};
DE   Flags: Fragment;
GN   ORFNames=N333_12877 {ECO:0000313|EMBL:KFQ50015.1};
OS   Nestor notabilis (Kea).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Psittaciformes; Psittacidae; Nestor.
OX   NCBI_TaxID=176057 {ECO:0000313|EMBL:KFQ50015.1, ECO:0000313|Proteomes:UP000053840};
RN   [1] {ECO:0000313|EMBL:KFQ50015.1, ECO:0000313|Proteomes:UP000053840}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N333 {ECO:0000313|EMBL:KFQ50015.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-
CC         (2->8)- glycosidic linkages of terminal sialic acid residues in
CC         oligosaccharides, glycoproteins, glycolipids, colominic acid and
CC         synthetic substrates.; EC=3.2.1.18;
CC         Evidence={ECO:0000256|ARBA:ARBA00000427};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 33 family.
CC       {ECO:0000256|ARBA:ARBA00009348}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KK940069; KFQ50015.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A091S254; -.
DR   Proteomes; UP000053840; Unassembled WGS sequence.
DR   GO; GO:0052794; F:exo-alpha-(2->3)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052795; F:exo-alpha-(2->6)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052796; F:exo-alpha-(2->8)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 2.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF22; SIALIDASE-4; 1.
DR   Pfam; PF13088; BNR_2; 1.
DR   SUPFAM; SSF50939; Sialidases; 1.
PE   3: Inferred from homology;
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00022963};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053840}.
FT   DOMAIN          36..263
FT                   /note="Sialidase"
FT                   /evidence="ECO:0000259|Pfam:PF13088"
FT   NON_TER         472
FT                   /evidence="ECO:0000313|EMBL:KFQ50015.1"
SQ   SEQUENCE   472 AA;  52176 MW;  1CB1992087A8E7D3 CRC64;
     MGSRHFPART VLFEKESNGV TYRVPALLYL PCVAKLLAFA EERLSADDAH ANLLVLRRGS
     IYGSYVEWED MRVLETATLQ HHRSMNPCPL YDEFTGTLFL FFITVLGRTP EAYQIVTGQN
     VTRLCCITST DQGLSWSKAT DLTQQVIGVH PWYWATFALG PGHGIQLRSG RLLVPAYSYH
     IDCKECFGQL CKTTPHSFAF YALYSDDPGR GWRFGEFIPN LQTGECQLVS VDEEDGSNVL
     YCNARSPLGF RVQALSTDDG AVFHGGQLVQ RLVEPPHGCH GSVVGFPAPF VYVPAPPRDA
     VVPIRGSASQ LRPRVLPGFR YLPAGQAVGD ELSAVATEPE EGCPTPGHHS HAHGNTLVRR
     DPAVTPRPAG FFQAPTWILY SHPTSSMSRV NMGVHLSTFP RDVESWTEPW VIYEGPSAYS
     DLAYMELPYN EASIAGGPAI AFACLYENGT RSPYEQISFS MFTLHDVLQN IP
//