ID A0A091SAM2_NESNO Unreviewed; 1025 AA.
AC A0A091SAM2;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Guanylate cyclase {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
DE EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
DE Flags: Fragment;
GN ORFNames=N333_04440 {ECO:0000313|EMBL:KFQ54007.1};
OS Nestor notabilis (Kea).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Psittaciformes; Psittacidae; Nestor.
OX NCBI_TaxID=176057 {ECO:0000313|EMBL:KFQ54007.1, ECO:0000313|Proteomes:UP000053840};
RN [1] {ECO:0000313|EMBL:KFQ54007.1, ECO:0000313|Proteomes:UP000053840}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N333 {ECO:0000313|EMBL:KFQ54007.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC Evidence={ECO:0000256|RuleBase:RU003431};
CC -!- SUBCELLULAR LOCATION: Photoreceptor outer segment membrane
CC {ECO:0000256|ARBA:ARBA00004451}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004451}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
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DR EMBL; KK945510; KFQ54007.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091SAM2; -.
DR Proteomes; UP000053840; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR CDD; cd07302; CHD; 1.
DR CDD; cd06371; PBP1_sensory_GC_DEF-like; 1.
DR CDD; cd14043; PK_GC-2D; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 6.10.250.780; -; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR011645; HNOB_dom_associated.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR11920:SF477; GUANYLATE CYCLASE D; 1.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07701; HNOBA; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 3: Inferred from homology;
KW cGMP biosynthesis {ECO:0000256|ARBA:ARBA00023293,
KW ECO:0000256|RuleBase:RU003431}; Coiled coil {ECO:0000256|SAM:Coils};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053840};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Vision {ECO:0000256|ARBA:ARBA00023305}.
FT TRANSMEM 416..438
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 552..571
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 488..758
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 830..960
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT COILED 767..794
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ54007.1"
FT NON_TER 1025
FT /evidence="ECO:0000313|EMBL:KFQ54007.1"
SQ SEQUENCE 1025 AA; 115091 MW; 1D8C011DFBAA488E CRC64;
FKIGLLGPWN CDPFFSKALP HVAARLAVER ITKDPSLDLG HRLDYVVLEE ECETSRALLR
FIDFRKLSSA FIGPLNPGFC EVATLLGENW NKAIFSWMCI NYKLDSTVHH PTFARTLPSP
IRVLFTIMKH FSWAHVGIIA SNEDIWMDTA NKLASALRNQ GLPVGIVTAM HKGEKGIEDT
WNKVKEVDGI KIIILCMHSV LIGGEEQATL LTKALEMGLA DGRYVFVPYD TLLYSLPYQN
NSFRVFDNDE KLQEAYDAVL TVTVESGERT FYDAFREAKT SGEITRDLEA TQVSPLFGTI
YDAFYFMAMA IDSARRKGAR VSGANIAQHT KNFSFPGFSH QVETDHCGKG LSNYVILDTD
GHGNQLFPTH LLDMSSDSVM SLGRDIHFPR ETLPKPDSSC WFDPDVLCTG GIEPTVIILG
VMVIFGLVLF AMGLASLIRH SVLNSQLFRG PNKIILTLDD LIFINPELQK KRMTLDSLTD
ANSVAADGRS LKSVTRSSSL KSEAATYETS NVALYEGDWV WLKKFGTGAA HHLRQSSTSI
LRKMKDLRHE NVNLFLGFFS DCGIFAIVTE YCSRGSLEDL LRNEDMKLDW MFKSSLVMDL
IKGIRYLHHR DFAHGRLKSR NCVVDGRFVL KITDYGYNEL LEAQKCPYIQ PPPEELLWTA
PELLRDPDMR RKGTFKGDIY SFAIILQEVV VRGPPYCMSE LSAEEIIKKV KKPPPLCRPN
IAPELAPMKC IQVMKECWGE APERRPTFEE VFLKFKTINK GKKTNIIDSM LRMLEQYSSN
LEDLIRERTE ELEIEKQKTE KLLSQMLPPS VAEALKTGGT VEPEYFDQVT IYFSDIVGFT
TISALSEPIE VVDLLNDLYT LFDAVLGNHD VYKVETIGDA YMVASGLPKR NGNKHAAEIA
NMSLDILSSV GSFKMRHMPD IPLRIRIGLH TGPCVAGVVG LTMPRYCLFG DTVNTASRME
STGLPYRIHV SQSTVDTLRS LNEGYEIVPR GKTELKGKGV EDTYWLVGKK GFLKPLPKPP
EIKPG
//
