GenomeNet

Database: UniProt
Entry: A0A091SJ45_9GRUI
LinkDB: A0A091SJ45_9GRUI
Original site: A0A091SJ45_9GRUI 
ID   A0A091SJ45_9GRUI        Unreviewed;       373 AA.
AC   A0A091SJ45;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   24-JAN-2024, entry version 35.
DE   RecName: Full=cathepsin E {ECO:0000256|ARBA:ARBA00013240};
DE            EC=3.4.23.34 {ECO:0000256|ARBA:ARBA00013240};
DE   Flags: Fragment;
GN   ORFNames=N332_09021 {ECO:0000313|EMBL:KFQ40270.1};
OS   Mesitornis unicolor (brown roatelo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Gruiformes; Mesitornithidae; Mesitornis.
OX   NCBI_TaxID=54374 {ECO:0000313|EMBL:KFQ40270.1, ECO:0000313|Proteomes:UP000053369};
RN   [1] {ECO:0000313|EMBL:KFQ40270.1, ECO:0000313|Proteomes:UP000053369}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N332 {ECO:0000313|EMBL:KFQ40270.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Similar to cathepsin D, but slightly broader specificity.;
CC         EC=3.4.23.34; Evidence={ECO:0000256|ARBA:ARBA00001898};
CC   -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000256|ARBA:ARBA00011748}.
CC   -!- SUBCELLULAR LOCATION: Endosome {ECO:0000256|ARBA:ARBA00004177}.
CC   -!- SIMILARITY: Belongs to the peptidase A1 family.
CC       {ECO:0000256|ARBA:ARBA00007447, ECO:0000256|RuleBase:RU000454}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KK821488; KFQ40270.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A091SJ45; -.
DR   MEROPS; A01.010; -.
DR   Proteomes; UP000053369; Unassembled WGS sequence.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.70.10; Acid Proteases; 2.
DR   InterPro; IPR001461; Aspartic_peptidase_A1.
DR   InterPro; IPR001969; Aspartic_peptidase_AS.
DR   InterPro; IPR012848; Aspartic_peptidase_N.
DR   InterPro; IPR033121; PEPTIDASE_A1.
DR   InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR   PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR   PANTHER; PTHR47966:SF26; CATHEPSIN E; 1.
DR   Pfam; PF07966; A1_Propeptide; 1.
DR   Pfam; PF00026; Asp; 1.
DR   PRINTS; PR00792; PEPSIN.
DR   SUPFAM; SSF50630; Acid proteases; 1.
DR   PROSITE; PS00141; ASP_PROTEASE; 2.
DR   PROSITE; PS51767; PEPTIDASE_A1; 1.
PE   3: Inferred from homology;
KW   Aspartyl protease {ECO:0000256|RuleBase:RU000454};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW   ECO:0000256|PIRSR:PIRSR601461-2}; Endosome {ECO:0000256|ARBA:ARBA00022753};
KW   Hydrolase {ECO:0000256|RuleBase:RU000454};
KW   Protease {ECO:0000256|RuleBase:RU000454};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053369}.
FT   DOMAIN          56..370
FT                   /note="Peptidase A1"
FT                   /evidence="ECO:0000259|PROSITE:PS51767"
FT   ACT_SITE        74
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT   ACT_SITE        259
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT   DISULFID        87..92
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
FT   DISULFID        250..254
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFQ40270.1"
FT   NON_TER         373
FT                   /evidence="ECO:0000313|EMBL:KFQ40270.1"
SQ   SEQUENCE   373 AA;  40616 MW;  8CCC317359A37C6B CRC64;
     RVTLTRHRSL RKTLRARGQL SHFWKAHGLN MVQYSQDCTA FTEANEPLIT YLDLEYFGQI
     SIGTPPQNFT VVFDTGSSNL WVPSVYCVSK ACTEHSRFQP SQSSTYQPIG TPFSIQYGTG
     SLTGVIGSDQ VVVEGLTISN QQFAESVSEP GKAFLDAEFD GILGLAYPSL AVDGVTPVFD
     NMMAQNLVEL PMFSVYLSSN PESSLGGELL FGGFDPSRFT GTLNWVPVTQ QGYWQIQLDN
     IQLGGTVVFC ANGCQAIVDT GTSLVTGPTK DIKELQGYIG AMSVDGEFAV ECSNMNVMPD
     VTFTINGLPY TLSAQAYTLM EYNDNMAFCT SGFQGLDITP PAGPLWILGD VFIRQFYSVF
     DRGNNRVGLA PAV
//
DBGET integrated database retrieval system