ID A0A091T6T1_PHALP Unreviewed; 701 AA.
AC A0A091T6T1;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
DE Flags: Fragment;
GN ORFNames=N335_10698 {ECO:0000313|EMBL:KFQ70096.1};
OS Phaethon lepturus (White-tailed tropicbird).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Eurypygimorphae; Phaethontiformes;
OC Phaethontidae; Phaethon.
OX NCBI_TaxID=97097 {ECO:0000313|EMBL:KFQ70096.1, ECO:0000313|Proteomes:UP000053638};
RN [1] {ECO:0000313|EMBL:KFQ70096.1, ECO:0000313|Proteomes:UP000053638}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N335 {ECO:0000313|EMBL:KFQ70096.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC multimeric enzyme that catalyzes the translocation of protons across
CC the membranes. Required for assembly and activity of the V-ATPase.
CC {ECO:0000256|RuleBase:RU361189}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, clathrin-coated vesicle
CC membrane {ECO:0000256|ARBA:ARBA00029431}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00029431}. Cytoplasmic vesicle, secretory
CC vesicle, synaptic vesicle membrane {ECO:0000256|ARBA:ARBA00004644};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004644}. Melanosome
CC {ECO:0000256|ARBA:ARBA00004223}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
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DR EMBL; KK440685; KFQ70096.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091T6T1; -.
DR PhylomeDB; A0A091T6T1; -.
DR Proteomes; UP000053638; Unassembled WGS sequence.
DR GO; GO:0030665; C:clathrin-coated vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
DR GO; GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR InterPro; IPR002490; V-ATPase_116kDa_su.
DR InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR PANTHER; PTHR11629:SF68; V-TYPE PROTON ATPASE 116 KDA SUBUNIT A 1; 1.
DR PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR Pfam; PF01496; V_ATPase_I; 1.
DR PIRSF; PIRSF001293; ATP6V0A1; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW ECO:0000256|RuleBase:RU361189};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361189};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW Reference proteome {ECO:0000313|Proteomes:UP000053638};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361189};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361189};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT TRANSMEM 300..324
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 344..363
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 441..462
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 468..492
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 533..557
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 670..697
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT REGION 571..591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ70096.1"
FT NON_TER 701
FT /evidence="ECO:0000313|EMBL:KFQ70096.1"
SQ SEQUENCE 701 AA; 79663 MW; CF81CE138397A819 CRC64;
IENELKEINT NQEALKRNFL ELTELKFILR KTQQFFDEVR IPGVDLLEES SSLLEPSEMG
RGAPLRLGFV AGVINRERIP MFERMLWRVC RGNVFLRQAE IENPLEDPVT GDYVHKSVFI
IFFQGDQLKN RVKKICEGFR ASLYPCPETP QERKEMASGV NTRIDDLQMV LNQTEDHRQR
VLQAAAKNIR VWFIKVRKMK AIYHTLNLCN IDVTQKCLIA EVWCPVADLD SIQFALRRGT
EHSGSTVPSI LNRMQTNQTP PTYNKTNKFT SGFQNIVDAY GIGTYREINP APYTIITFPF
LFAVMFGDFG HGILMTLIAV WMVLRESRIL SQKSDNEMFN MVFSGRYIIL LMGLFSTYTG
LIYNDCFSKS LNMFGSSWSV RPMFSKGNWS DALLENTPLL QLNPAIPGVF GGPYPFGIDP
IWNIASNKLA FLNSFKMKMS VILGIIHMIF GVTLSLLNHI YFKKPLNIYL GFIPEIIFMS
SLFGYLVILI FYKWTAYDAH TSKDAPSLLI HFINMFLFSY SDTSNKMLYK GQQGLQCFLV
VVALLCVPWM LVAKPLVLRH QYLRRKHLVG RATRGGPSQH SPERAGTRGS SGCNSRLISA
FSLQFDFGDT VVYQAIHTIE YCLGCISNTA SYLRLWALSL AHAQLSEVLW TMVIHIGLSV
RSLGGGFGLF FIFAAFATLT VAILLVMEGL SAFLHALRLH W
//
