ID A0A091TLH2_PHALP Unreviewed; 2989 AA.
AC A0A091TLH2;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Putative E3 ubiquitin-protein ligase HECTD4 {ECO:0000313|EMBL:KFQ76426.1};
DE Flags: Fragment;
GN ORFNames=N335_00735 {ECO:0000313|EMBL:KFQ76426.1};
OS Phaethon lepturus (White-tailed tropicbird).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Eurypygimorphae; Phaethontiformes;
OC Phaethontidae; Phaethon.
OX NCBI_TaxID=97097 {ECO:0000313|EMBL:KFQ76426.1, ECO:0000313|Proteomes:UP000053638};
RN [1] {ECO:0000313|EMBL:KFQ76426.1, ECO:0000313|Proteomes:UP000053638}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N335 {ECO:0000313|EMBL:KFQ76426.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KK456117; KFQ76426.1; -; Genomic_DNA.
DR PhylomeDB; A0A091TLH2; -.
DR Proteomes; UP000053638; Unassembled WGS sequence.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR CDD; cd13735; SPRY_HECT_like; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR043366; HECTD4.
DR InterPro; IPR035781; SPRY_HECTD4.
DR PANTHER; PTHR46435; E3 UBIQUITIN-PROTEIN LIGASE HECTD4-RELATED; 1.
DR PANTHER; PTHR46435:SF1; E3 UBIQUITIN-PROTEIN LIGASE HECTD4-RELATED; 1.
DR Pfam; PF00632; HECT; 1.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS50237; HECT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000053638};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 2630..2989
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 501..529
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1225..1251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1853..1907
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2019..2044
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2320..2396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1853..1880
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2029..2044
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2320..2337
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2350..2364
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2366..2396
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 2957
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ76426.1"
FT NON_TER 2989
FT /evidence="ECO:0000313|EMBL:KFQ76426.1"
SQ SEQUENCE 2989 AA; 327291 MW; 26D9DA0CD6648A98 CRC64;
SKMKELELLC SMKEVSFDGS DLENVVLALR EKFFQEVNSL IQKTSHPLAK TKTLVKSLMN
RAELLLHVTI AAQSGITRSI SGTPAETPAC KSASETKVIS HAVRQPVFLR SMSAPSDLEM
IGNEDIEFAR SSQRRRHVTS HRSSSFTLLQ SLTIEDTRDK PTYSVLLGQL FAFIGTNPDQ
AVSSSSFLLA AQTRWRRGNT RKQALVHMRE LLTAAVRVGG VTHLVGPVTM VLQGGPRIEE
LTCGGMVEQV QEAFGETMTS VVSLCARYPI ACANSIGLLC TIPYTRSEEK CLVRSGLVQL
MDRLCSLSSQ TESSSNEKQT KKQKVATMAW AAFQVLANRC VEWEKEEGGS TEAVHSGLAR
QVSSLLTNHL ARATECCGNQ AAGNDALQDV LSLLNDLSRS HIGKAILSQP ACVSKLLSLL
LDQRPSPKLV LIILQLCRAA LPLMSVEDCG NVELPPWSYS VPSLNSEQDD PSDPASKIAS
LLLAKLADYV VPGCQTVLSP TASEPDTTLA KASPKNSIKG DKDPGEESEA VDGKLSIFIH
KREDQSSHEV LQPLLSSSEG RPFRLGTGAN MEKVVKMDRD MTKSGCCEVI TEEAAAALRK
ATKWAQSGLI VSVGPPIETI NPETTSGLST GDKKKTAQTS ICRERNSELA RTDPVRPFIS
GHVANSMAAE VIALLHSLLM APESNAAQIW TTTAEKVLSR ALMYIPQLGK YAESILENGS
SSGRKLAKLQ RIARQAVAAL CALGGFKETI KIGSEVQVLG KGIAGSIGVV ASINEQEGIA
TVKFPPTSID SRKTSQASDT LTIPLSRLCV PRSEALPLHK LSITEKVVQA VQSMLLPQEG
SLSIHTSLPA TGDGSTPVMA VVRLLAEIRT RACLVMAQLL EDSSFCEEFI QQCPAAVEVL
NLVAQECSPG ERLLVVEMQC ERLRMLYRDC ARPPPPPLQA DRRQPKEITW SPSRVFPPVR
ACMFSSHLTA VTFLADPSAG GGLPRGTFIY ATSPVPVQAP SFYWEIEIVS YGDTDDDTGP
IVSFGFATEA EKRDGAWTNP VGTCLFHNNG RAVHYNGSSL LQWKSVRLDV TLSPGDVAGI
GWERTEGTPP PPGQPAKGRV YFTYCGQRLG PYLEDVSGGM WPVVHIQKKA IRANFGSRQF
AYAEGQAHRN AADLCIDLAE EISANFEALP FAMASDSDND AGTSIASDPG THGPPCRIAA
VATAQQQYDS DTSCHYKMEL SYENFITSGP DPHPPPIADD ESDDDDDDDI PREDHYALLV
KAWETKAERK SGLDQIKGAL QLGMVDIARQ TVEFLYEENG GIPRDLYLPT IEDIKDEANK
FTIDKVRKGL TVVTRSPDSN NVTSSAVGTA LPKFAIRGML KTFGLHGVVL DVDSVNELVQ
VETYLRSEGV LVRYWYPIDM LERPPAGYRR TATNGLVTLD NTNIQIHREL LRSEASLAKL
YCRMALLNIF APKSPHMFTR LFHIPAIRDI TLEHLQLLSN QLLAPPLPDG TISSSSILLA
QSLQHCIHSQ NCAATDLFYQ GNSQAIREWL TVAITRTLHQ GEESLLDLTK QICSFLQVKY
SVMVYEQFPI SESKVNMDVN FPGAAFVIVS CKESQSGFRK DSSLYKAPWA RVLVYGLGHK
VKRNGQLNLI EAVCYPRDAS PTNTGLTPPP TTNQYPSVIT PTDKVHIKLG VSPPPGAVLV
LHSLPLEFPL AMAFTEQLLT WKLEDGGGKS EDELDTIPAS VLLQVVEFLG NFLWTTDMAA
CVKELIFQLL AELLRKIHNL EQKKNPAGLS SSIALQLNPC LAMLMALQSE LHKLYDEETQ
NWVSGNACSG SGVGGADQGR FSTYFHALME VCLAVAEVTL PINMSVTANV MSSTSAPNLS
DSSSSSSSSP GQTPQSPSLL SKRKKVKMKR EKTSSSGKRS SSRAAETDAA MLSIGGSKPE
DMLWFHRALT LLIILRHLTK KDPQGLGVTN DAVADACQAL VGPTAHSRLL VISGIPTHLE
ESTVRSAIRK ACNAHGGVFK DEIYIPLQEE DPKKIKDKAE GGECRTELEK PTVSSSADSL
DISSSSSVTP AMSVSASAST SQASLCSSQG ISRTVSDISV DQFQAGLELA IPPGLLEPHV
VSSQESLDLS HCSTGSLGSL GSLGEPLDNV ETASVSDVGS MYTVTSLDNQ LLLSRPIKGF
AVVEIRSRAK IEKIRASLFN SSDLIGLSSL DGEDELMEMS TEEILTVSTV NQSLFDTQGS
PALEDYFNDK SIKGEKLVPG AREVLTEIFK SCIHSEQMLS LTPAKPIKVA DLYLSKEQIN
SQTPGNLLHV FFTNVRPPKK VLEDQLTQIL RKYGVPKPKF DKSKYNKAGK EQHPVKVVST
KRPVTKPPTK EKSMLNSVSR TALSEKKPTV KPKSPEKSKP EEKDPEKSPT KKQEVPEEKY
LTLDGFHRFV VDRSKQDIRS VWRAILSCGY DLHFERCACI DARHAQKASR KWTLEMDVAL
VQYINRLCRH LAITPARLHP HEVYLDPADA ADPRISCLLN VPVESLRLRF ALLQSLNTTL
ETFFLPLVEL RQTEMYANSI AALLQEAKGL IFYDTKVTVM NRVLNATVQR TADHAAPEIT
LDPLEIVGGE IRSSENSYFC QAARQLACVP SSQLCVKLAS GGDPTYAFNI RFTGEEVHGT
SGSFRHFLWQ VCKELQSSSL SLLLLCPSSA VNKNKGKYIL TPSPITYAEE QLFHFFGQLL
GIAIRADVPL PLDLLPSFWK TLVGEPLDPD IDLQEADILT YNYVKKFENI NDETELEALC
AEVASQHLAT ESPDCPNKPC CKFTYLTMTG EEVELCPRGR HIPVGWENKD VYATAIRSLR
MRELQTPECM TAVRAGLGSI IPLQLLTTLT PLEMELRTCG LPYINLEFLK AHTMYQVGLM
ETDQHIEFFW SALEMFTQEE LCKFIKFACN QERIPFTCPC KDGGPDTAHV PPYPMKIAPP
DGAAGSPDSR YIRVETCMFM IKLPQYSSLD IMLEKLRYAI HYREDPLSG
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