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Database: UniProt
Entry: A0A091TS56_PHALP
LinkDB: A0A091TS56_PHALP
Original site: A0A091TS56_PHALP 
ID   A0A091TS56_PHALP        Unreviewed;       636 AA.
AC   A0A091TS56;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   RecName: Full=Macoilin {ECO:0000256|ARBA:ARBA00021882};
DE   AltName: Full=Transmembrane protein 57 {ECO:0000256|ARBA:ARBA00031129};
DE   Flags: Fragment;
GN   ORFNames=N335_07737 {ECO:0000313|EMBL:KFQ81159.1};
OS   Phaethon lepturus (White-tailed tropicbird).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Eurypygimorphae; Phaethontiformes;
OC   Phaethontidae; Phaethon.
OX   NCBI_TaxID=97097 {ECO:0000313|EMBL:KFQ81159.1, ECO:0000313|Proteomes:UP000053638};
RN   [1] {ECO:0000313|EMBL:KFQ81159.1, ECO:0000313|Proteomes:UP000053638}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N335 {ECO:0000313|EMBL:KFQ81159.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in the regulation of neuronal activity.
CC       {ECO:0000256|ARBA:ARBA00003440}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}. Nucleus membrane
CC       {ECO:0000256|ARBA:ARBA00004232}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004232}. Rough endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004269}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004269}.
CC   -!- SIMILARITY: Belongs to the macoilin family.
CC       {ECO:0000256|ARBA:ARBA00008298}.
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DR   EMBL; KK464782; KFQ81159.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A091TS56; -.
DR   PhylomeDB; A0A091TS56; -.
DR   Proteomes; UP000053638; Unassembled WGS sequence.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030867; C:rough endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0023041; P:neuronal signal transduction; IEA:InterPro.
DR   InterPro; IPR019130; Macoilin.
DR   PANTHER; PTHR47464; MACOILIN; 1.
DR   PANTHER; PTHR47464:SF2; MACOILIN; 1.
DR   Pfam; PF09726; Macoilin; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053638};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        47..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        90..108
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        128..148
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          295..347
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          605..636
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          355..523
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          565..592
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        295..323
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        605..627
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFQ81159.1"
FT   NON_TER         636
FT                   /evidence="ECO:0000313|EMBL:KFQ81159.1"
SQ   SEQUENCE   636 AA;  73019 MW;  2DA07E8E2FC60E27 CRC64;
     STFLYLKFLV VWALVLLADF VLEFRFEYLW PFWLFIRSVY DSFRYQGLAF SVFFVCVAFT
     SNIICLLFIP IQWLFFAAST YVWVQYVWHT ERGVCLPTVS LWILFVYIEA AIRFKDLKNF
     HVDLCRPFAA HCIGYPVVTL GFGFKSYVSY KMRLRKQKEV QKENEFYMQL LQQALPPEQQ
     MLQRQEREAE EGKGLSDIDS SILLQHNGGI PANKKLSATL PELEYREKGK EKDKDAKKHN
     LGINNNILQP VDSKIQEIEY MENHINSKRL NNDLVGSTEN LLKEDSCTAS SKNYKNVSGV
     VNSSPRSHSA TNGSIPSSST KNEKKQKCAS KSPSTHKDLM ENCIPNNQLS KPDALVRLEQ
     DIKKLKADLQ ASRQIEQELR SQISSLTNIE RGIRSEIGQL RQENELLQNK LHNAVQMKQK
     DKQMISQLEK KLKAEQEARA FVEKQLMEEK KRKKLEEATA ARAVAFAAAT RGECTETLRN
     RIRELETECK KLTIDIKLKE DQIRELEMKV QELRKYKENE KDTEVLMSAL SAMQDKTQHL
     ENSLSAETRI KLDLFSALGD AKRQLEIAQG QIIQKDQEIK DLKQKIAEVM AVMPSITYTA
     ATSTLSPVSP HYSSKFVETS PSGLDPNASV YQPLKK
//
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