ID A0A091U4D0_PHORB Unreviewed; 132 AA.
AC A0A091U4D0;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Insulin-induced gene protein {ECO:0000256|RuleBase:RU241113};
DE Flags: Fragment;
GN ORFNames=N337_06757 {ECO:0000313|EMBL:KFQ85614.1};
OS Phoenicopterus ruber ruber.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Phoenicopteriformes; Phoenicopteridae;
OC Phoenicopterus.
OX NCBI_TaxID=9218 {ECO:0000313|EMBL:KFQ85614.1, ECO:0000313|Proteomes:UP000053700};
RN [1] {ECO:0000313|EMBL:KFQ85614.1, ECO:0000313|Proteomes:UP000053700}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N337 {ECO:0000313|EMBL:KFQ85614.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mediates feedback control of cholesterol synthesis.
CC {ECO:0000256|RuleBase:RU241113}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the INSIG family.
CC {ECO:0000256|ARBA:ARBA00007475, ECO:0000256|RuleBase:RU241113}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU241113}.
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DR EMBL; KK417224; KFQ85614.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091U4D0; -.
DR Proteomes; UP000053700; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
DR InterPro; IPR025929; INSIG_fam.
DR PANTHER; PTHR15301; INSULIN-INDUCED GENE 1; 1.
DR PANTHER; PTHR15301:SF10; INSULIN-INDUCED GENE 2 PROTEIN; 1.
DR Pfam; PF07281; INSIG; 1.
PE 3: Inferred from homology;
KW Cholesterol metabolism {ECO:0000256|ARBA:ARBA00022548,
KW ECO:0000256|RuleBase:RU241113};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Lipid metabolism {ECO:0000256|RuleBase:RU241113};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU241113};
KW Reference proteome {ECO:0000313|Proteomes:UP000053700};
KW Steroid metabolism {ECO:0000256|RuleBase:RU241113};
KW Sterol metabolism {ECO:0000256|ARBA:ARBA00023166};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU241113};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU241113}.
FT TRANSMEM 51..68
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU241113"
FT TRANSMEM 75..94
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU241113"
FT TRANSMEM 106..126
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU241113"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ85614.1"
FT NON_TER 132
FT /evidence="ECO:0000313|EMBL:KFQ85614.1"
SQ SEQUENCE 132 AA; 14624 MW; 7E0BE36950ECFA47 CRC64;
TAVIGLLYPC MDRHLGEPHK FKREWSSVMR CVAVFVGINH ASAKVDFANN IQLSLTLAAL
SIGLWWTFDR SRSGFGLGVG IAFLATLVSQ LLVYNGVYQY TSPDFLYVRS WLPCIFFAGG
ITMGNIGRQL AM
//
