ID   A0A091UNU9_NIPNI        Unreviewed;       392 AA.
AC   A0A091UNU9;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   SubName: Full=Betaine--homocysteine S-methyltransferase 1 {ECO:0000313|EMBL:KFQ91595.1};
DE   Flags: Fragment;
GN   ORFNames=Y956_12854 {ECO:0000313|EMBL:KFQ91595.1};
OS   Nipponia nippon (Crested ibis) (Ibis nippon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Pelecaniformes; Threskiornithidae;
OC   Nipponia.
OX   NCBI_TaxID=128390 {ECO:0000313|EMBL:KFQ91595.1, ECO:0000313|Proteomes:UP000053283};
RN   [1] {ECO:0000313|EMBL:KFQ91595.1, ECO:0000313|Proteomes:UP000053283}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_Y956 {ECO:0000313|EMBL:KFQ91595.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|PIRSR:PIRSR037505-2};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000256|PIRSR:PIRSR037505-2};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de novo
CC       pathway; L-methionine from L-homocysteine (BhmT route): step 1/1.
CC       {ECO:0000256|ARBA:ARBA00005137}.
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DR   EMBL; KL409751; KFQ91595.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A091UNU9; -.
DR   STRING; 128390.A0A091UNU9; -.
DR   eggNOG; KOG1579; Eukaryota.
DR   UniPathway; UPA00051; UER00083.
DR   Proteomes; UP000053283; Unassembled WGS sequence.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:InterPro.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.20.20.330; Homocysteine-binding-like domain; 1.
DR   InterPro; IPR017226; Betaine-hCys_S-MeTrfase_BHMT.
DR   InterPro; IPR003726; HCY_dom.
DR   InterPro; IPR036589; HCY_dom_sf.
DR   PANTHER; PTHR46120; BETAINE--HOMOCYSTEINE S-METHYLTRANSFERASE 1; 1.
DR   PANTHER; PTHR46120:SF1; HCY-BINDING DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF02574; S-methyl_trans; 1.
DR   PIRSF; PIRSF037505; Betaine_HMT; 1.
DR   SUPFAM; SSF82282; Homocysteine S-methyltransferase; 1.
DR   PROSITE; PS50970; HCY; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR037505-2, ECO:0000256|PROSITE-
KW   ProRule:PRU00333};
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW   ProRule:PRU00333}; Reference proteome {ECO:0000313|Proteomes:UP000053283};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW   ProRule:PRU00333};
KW   Zinc {ECO:0000256|PIRSR:PIRSR037505-2, ECO:0000256|PROSITE-
KW   ProRule:PRU00333}.
FT   DOMAIN          1..304
FT                   /note="Hcy-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50970"
FT   BINDING         207
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR037505-2,
FT                   ECO:0000256|PROSITE-ProRule:PRU00333"
FT   BINDING         289
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR037505-2,
FT                   ECO:0000256|PROSITE-ProRule:PRU00333"
FT   BINDING         290
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR037505-2,
FT                   ECO:0000256|PROSITE-ProRule:PRU00333"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFQ91595.1"
FT   NON_TER         392
FT                   /evidence="ECO:0000313|EMBL:KFQ91595.1"
SQ   SEQUENCE   392 AA;  43522 MW;  47B49BD65903E28A CRC64;
     QGILERLDAG EIVIGDGGFV FALEKRGYVK AGPWTPEATV EHPEAVRQLH REFLRAGSNV
     LQTFTFYASE DKLENRGNYV AEKISCQKVN EAACDIAREV ANEGDALVAG GVSQTPSYLS
     CKDKAEVKAA FRKQLDVFMK KNVDFLIAEY FEHVEEAVWA VEVLKESGKP VAATMCIGPE
     GDMHGVPPGQ CAVQLVKAGA SVVGVNCHFD PDTCLETVKR MKEGLQAAKL KAHLMSQPLA
     FHTPDCGKQG FIDLPEFPFG LEPRIVTRWD IQNYARKAYD LGIRYIGGCC GFEPYHIRAI
     AEELAPERGF LPEASEKHGS WGDGLSMHTK PWVRARARKE YWENLKPASG RPYCPSMSKP
     DGWGVTKGAR ELMQQKEATS EQQLKELFQK QK
//