ID A0A091UTH0_NIPNI Unreviewed; 476 AA.
AC A0A091UTH0;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=methylcrotonoyl-CoA carboxylase {ECO:0000256|ARBA:ARBA00026116};
DE EC=6.4.1.4 {ECO:0000256|ARBA:ARBA00026116};
DE AltName: Full=3-methylcrotonyl-CoA carboxylase 2 {ECO:0000256|ARBA:ARBA00031404};
DE AltName: Full=3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit {ECO:0000256|ARBA:ARBA00031109};
DE AltName: Full=3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta {ECO:0000256|ARBA:ARBA00031237};
DE Flags: Fragment;
GN ORFNames=Y956_08781 {ECO:0000313|EMBL:KFQ94001.1};
OS Nipponia nippon (Crested ibis) (Ibis nippon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Pelecaniformes; Threskiornithidae;
OC Nipponia.
OX NCBI_TaxID=128390 {ECO:0000313|EMBL:KFQ94001.1, ECO:0000313|Proteomes:UP000053283};
RN [1] {ECO:0000313|EMBL:KFQ94001.1, ECO:0000313|Proteomes:UP000053283}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_Y956 {ECO:0000313|EMBL:KFQ94001.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-methyl-(2E)-butenoyl-CoA + ATP + hydrogencarbonate = 3-
CC methyl-(2E)-glutaconyl-CoA + ADP + H(+) + phosphate;
CC Xref=Rhea:RHEA:13589, ChEBI:CHEBI:15378, ChEBI:CHEBI:17544,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57344,
CC ChEBI:CHEBI:57346, ChEBI:CHEBI:456216; EC=6.4.1.4;
CC Evidence={ECO:0000256|ARBA:ARBA00029358};
CC -!- PATHWAY: Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-
CC 3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3.
CC {ECO:0000256|ARBA:ARBA00025711}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KL410116; KFQ94001.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091UTH0; -.
DR STRING; 128390.A0A091UTH0; -.
DR eggNOG; KOG0540; Eukaryota.
DR UniPathway; UPA00363; UER00861.
DR Proteomes; UP000053283; Unassembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:InterPro.
DR GO; GO:0006552; P:leucine catabolic process; IEA:UniProtKB-UniPathway.
DR InterPro; IPR034733; AcCoA_carboxyl_beta.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR011763; COA_CT_C.
DR InterPro; IPR011762; COA_CT_N.
DR InterPro; IPR045190; MCCB/AccD1-like.
DR PANTHER; PTHR22855; ACETYL, PROPIONYL, PYRUVATE, AND GLUTACONYL CARBOXYLASE-RELATED; 1.
DR PANTHER; PTHR22855:SF47; METHYLCROTONOYL-COA CARBOXYLASE; 1.
DR Pfam; PF01039; Carboxyl_trans; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 2.
DR PROSITE; PS50989; COA_CT_CTER; 1.
DR PROSITE; PS50980; COA_CT_NTER; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000053283}.
FT DOMAIN 1..248
FT /note="CoA carboxyltransferase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50980"
FT DOMAIN 247..476
FT /note="CoA carboxyltransferase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50989"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ94001.1"
FT NON_TER 476
FT /evidence="ECO:0000313|EMBL:KFQ94001.1"
SQ SEQUENCE 476 AA; 51435 MW; 7CDF682D41BCB814 CRC64;
ELLEMASKGG GENAILRHTQ RNKKLFVRER LKLLLDDESF LELSPLAGLN MPYGDVPAAG
CLTGIGKICG VWCVFMANDA TVKGGTIYPI GVKKQLRAQE IAMQNRLLSV YLVDSGGAFL
PLQSELFPDK SHGGRVFYNE AIMSAMRIPQ VAVVCGSCVA GGAYVPTMAE ETVIIDKIGT
LFLAGPPLVK AATGEDVSPE DLGGAKLHSK VSGCSDHFAS SEKEAYECIR NVISTLNYDP
LPEEVVEHDS PLYSSDELLG LAPQDYRLTL PVKLILSRLM DGSRFQEFKA NYGTTLVTGF
GHVEGHLVGV VANNGELSHD ASLKGSHFVQ LCSQRSIPIL FFQNTAPHTA EPTSISQAEA
HSNRLKAQAS MMAAVACAAV PKITIVIGGC YGSESYVMCG RSFSPNFLFL WPNARVALVD
SRHFSTVPQA GDSDCTGDES ELKHLKEKLE EESSAFYSSA RLWDDGVILP QNTRKV
//
