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Database: UniProt
Entry: A0A091UVY0_NIPNI
LinkDB: A0A091UVY0_NIPNI
Original site: A0A091UVY0_NIPNI 
ID   A0A091UVY0_NIPNI        Unreviewed;      2013 AA.
AC   A0A091UVY0;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   28-FEB-2018, entry version 23.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   ORFNames=Y956_02222 {ECO:0000313|EMBL:KFQ94612.1};
OS   Nipponia nippon (Crested ibis) (Ibis nippon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Pelecaniformes; Threskiornithidae;
OC   Nipponia.
OX   NCBI_TaxID=128390 {ECO:0000313|EMBL:KFQ94612.1, ECO:0000313|Proteomes:UP000053283};
RN   [1] {ECO:0000313|EMBL:KFQ94612.1, ECO:0000313|Proteomes:UP000053283}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_Y956 {ECO:0000313|EMBL:KFQ94612.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; KL410194; KFQ94612.1; -; Genomic_DNA.
DR   Proteomes; UP000053283; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   SMART; SM00015; IQ; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000053283};
KW   Ion channel {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000313|EMBL:KFQ94612.1};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00085096};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053283};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084820};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084701};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    258    278       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    408    435       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    760    784       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    796    817       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    879    907       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    969    992       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1218   1236       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1257   1279       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1334   1360       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1458   1482       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1540   1558       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1570   1588       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1600   1620       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1657   1685       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1761   1784       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      140    442       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      516    718       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      769    997       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1006   1212       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1216   1490       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1539   1794       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED       22     42       {ECO:0000256|SAM:Coils}.
FT   COILED      432    477       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2013 AA;  228990 MW;  0DE4F0FBF32D17BD CRC64;
     MAQSVLVPPG PDSFRYFTRE SLAAIEQRVN EEKAKKSKQE RKDDDDEDGP KPNSDLEAGK
     TLPFIYGDIP PGMVSEPLED LDPYYINKKT FIVLNKGKAI FRFSATSALY MLTPFNPLRK
     IAIKILVHSY PFQVVSLKLM LIMCTILTNC VFMTMSNPPD WTKNVEYTFT GIYTFESLIK
     ILARGFCLED FTFLRDPWNW LDFTVITFAY VTEFVDLGNV SALRTFRVLR ALKTISVIPG
     LKTIVGALIQ SVKKLSDVMI LTVFCLSVFA LIGLQLFMGN LRNKCLQWPP DNSTFETTVI
     SYFNSSIGEN GTFINTTMTT FNWDEYIEDR NHFYFLEGQN DALLCGNSSD AGQCPEGYIC
     VKAGRNPNYG YTSFDTFSWA FLSLFRLMTQ DFWENLYQLT LRAAGKTYMI FFVLVIFLGS
     FYLINLILAV VAMAYEEQNQ ATMEEAEQKE AEFQQMLEQL KKQQEEAQAA AAAAAADSRD
     YSGVGGVGGF SESSSEASKL SSKSAKERRN RRKKKKQKEQ SEGEEKDGEE FHKSESEDSI
     KRKGFRFSIE GNRLTYEKRF SSPHQSLLSI RGSLFSPRRN SRTSLFSFRG RAKDVGSEND
     FADDEHSTFE DNESRRDSLF VPHRHGERRN SNISQASRSS RTVPPLPANG KMHSTVDCNG
     VVSLVGGPPA LTSPTGQLLP EGTTTETDLR KRRSSSYHVP MDYLTDPSAR QRAMSIASML
     TNTMEELEES RQKCPPCWYK FANTCLIWDC CTPWLKVKHI VNLIVMDPFV DLAITICIVL
     NTLFMAMEHY PMTEQFSGVL SVGNLVFTGI FTAEMFLKII AMDPYYYFQE GWNIFDGFIV
     SLSLMELGLA NVEGLSVLRS FRLLRVFKLA KSWPTLNMLI KIIGNSVGAL GNLTLVLAII
     VFIFAVVGMQ LFGKSYKECV CKISSDCELP RWHMHDFFHS FLIVFRVLCG EWIETMWDCM
     EVAGQTMCLT VFMMVMVIGN LVVLNLFLAL LLSSFSSDNL AATDDDNEMN NLQIAVARIQ
     KGIDYVKRKV REFIQKAFVR KQKVLDEIKP LEDLNNKKDS CISNHTIVDI GKNLAYLKEG
     NGTTSGIGSS VEKYVVDESD YMSFINNPSL TVTVPIAVGE SDFENLNTEE FSSESDLEES
     KEKLNASSSS EGSTVDIGLP PEGEQPEAEP EEALEPEACF TEGCVRRFKC CQVSVEDGKG
     KIWWNLRKTC YKIVEHNWFE TFIVFMILLS SGALAFEDIY IEQRKTIKTM LEYADKVFTY
     IFILEMLLKW VAYGFQTYFT NAWCWLDFLI VDVSLVSLTA NALGYSELGA IKSLRTLRAL
     RPLRALSRFE GMRVVVNALL GAIPSIMNVL LVCLIFWLIF SIMGVNLFAG KFYYCVNTTT
     DERFDISQIN NYSQCEELIK NNETARWKNV KVNFDNVGLG YLSLLQVATF KGWMDIMYAA
     VDSRNVLDQP KYEDNLYMYL YFVIFIIFGS FFTLNLFIGV IIDNFNQQKK KISQDIFMTE
     EQKKYYNAMK KLGSKKPQKP IPRPANKFQG MVFDFVTKQA FDISIMILIC LNMVTMMVET
     DDQSEDMENI LYWINLVFIV LFTGECVLKL ISLRHYYFTI GWNIFDFVVV ILSIVGMFLA
     EMIEKYFVSP TLFRVIRLAR IGRILRLIKG AKGIRTLLFA LMMSLPALFN IGLLLFLVMF
     IYAIFGMSNF AYVKREVGID DMFNFETFGN SMICLFQITT SAGWDGLLAP ILNSGEPDCD
     PHKDHPGSSV KGDCGNPSVG IFFFVSYIII SFLVVVNMYI AVILENFSVA TEESAEPLSE
     DDFEMFYEVW EKFDPDATQF IEFSKLSDFA ASLDPPLLIA KPNKVQLIAM DLPMVSGDRI
     HCLDILFAFT KRVLGESGEM DALRIQMEDR FMAANPSKVS YEPITTTLKR KQEEVSAVII
     QRAFRRHLLR QKVKKVSCIF NQDKGKDEDD LPMKEDMIMD KLNENSTPEK TDMTPSTTSP
     PSYDSVTKPD KDKYEKDKSE KEDKGKDSRE SKK
//
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