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Entry: A0A091UXH8_NIPNI
LinkDB: A0A091UXH8_NIPNI
Original site: A0A091UXH8_NIPNI 
ID   A0A091UXH8_NIPNI        Unreviewed;      2154 AA.
AC   A0A091UXH8;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   25-OCT-2017, entry version 19.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
DE   Flags: Fragment;
GN   ORFNames=Y956_15229 {ECO:0000313|EMBL:KFQ95371.1};
OS   Nipponia nippon (Crested ibis) (Ibis nippon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Pelecaniformes; Threskiornithidae;
OC   Nipponia.
OX   NCBI_TaxID=128390 {ECO:0000313|EMBL:KFQ95371.1, ECO:0000313|Proteomes:UP000053283};
RN   [1] {ECO:0000313|EMBL:KFQ95371.1, ECO:0000313|Proteomes:UP000053283}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_Y956 {ECO:0000313|EMBL:KFQ95371.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1C
CC       gives rise to L-type calcium currents. Long-lasting (L-type)
CC       calcium channels belong to the 'high-voltage activated' (HVA)
CC       group. They are blocked by dihydropyridines (DHP),
CC       phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA
CC       (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-
CC       GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing the alpha-1C subunit play an important
CC       role in excitation-contraction coupling in the heart. Binding of
CC       calmodulin or CABP1 at the same regulatory sites results in an
CC       opposit effects on the channel function.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR   EMBL; KL410276; KFQ95371.1; -; Genomic_DNA.
DR   Proteomes; UP000053283; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR031688; CAC1F_C.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005452; LVDCC_a1dsu.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005446; VDCC_L_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF139; PTHR10037:SF139; 1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16885; CAC1F_C; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01630; LVDCCALPHA1.
DR   PRINTS; PR01636; LVDCCALPHA1D.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000053283};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053283};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    111    128       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    148    168       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    180    198       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    252    275       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    331    352       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    364    386       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    521    539       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    559    582       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    651    670       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    723    750       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    885    903       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    923    943       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    955    981       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1016   1038       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1072   1093       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1113   1140       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1192   1212       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1224   1244       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1256   1277       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1342   1365       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1434   1457       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1591   1625       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED      753    787       {ECO:0000256|SAM:Coils}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:KFQ95371.1}.
FT   NON_TER    2154   2154       {ECO:0000313|EMBL:KFQ95371.1}.
SQ   SEQUENCE   2154 AA;  245105 MW;  98F48CDAB3A1F604 CRC64;
     EVNYASSTRI PLPGDGPAIQ SNSSAPSKQT VLSWQAAIDA ARQAKAAQNM STTTTQPVGS
     LSQRKRQQYA KSKKQGNTSN SRPPRALFCL SLNNPIRRAC ISLVEWKPFD IFILLSIFAN
     CVALAVYIPF PEDDSNSTNH NLEKVEYAFL IIFTVETFLK IIAYGLLLHP NAYVRNGWNL
     LDFVIVVVGL FSVILEQLTK ETEGGGHSGG KPGGFDVKAL RAFRVLRPLR LVSGVPSLQV
     VLNSIIKAMV PLLHIALLVL FVIIIYAIIG LELFIGKMHK SCFLIDSDIL VEEDPAPCAF
     SGNGRQCVMN GTECKGGWVG PNGGITNFDN FAFAMLTVFQ CITMEGWTDV LYWVNDAIGC
     EWPWIYFVSL IILGSFFVLN LVLGVLSGEF SKEREKAKAR GDFQKLREKQ QLEEDLKGYL
     DWITQAEDID PENDEEVDEE GKRNRVTLAD LMEEKKKSRL SCFGRSSNKH ASMPTSETES
     VNTENVSGEG ENPACCGSLC RRWRRWNRFN RRKCRAAVKS VTFYWLVIVL VFLNTLTISS
     EHYNQPDWLT QIQDIANKVL LALFTCEMLV KMYSLGLQAY FVSLFNRFDC FVVCGGIVET
     ILVELEIMSP LGISVFRCVR LLRIFKVTRH WASLSNLVAS LLNSMKSIAS LLLLLFLFII
     IFSLLGMQLF GGKFNFDETQ TKRSTFDNFP QALLTVFQIL TGEDWNAVMY DGIMAYGGPS
     SSGMIVCIYF IILFICGNYI LLNVFLAIAV DNLADAESLN TAQKEEAEEK ERKKNARKES
     LENKKSEKSE GDQKKPKDSK VTIAEYGEGE DEDKDPYPPC DVPVGEDEED EEDEPEVPAG
     PRPRRISELN MKEKITPIPE GSAFFIFSST NPIRVGCHRL INHHIFTNLI LVFIMLSSVS
     LAAEDPIRSH SFRNNILGYA DYVFTSMFTF EIILKVTAFG AFLHKGSFCR NYFNLLDLLV
     VGVSLVSFGI QSSAISVVKI LRVLRVLRPL RAINRAKGLK HVVQCVFVAI RTIGNIMIVT
     TLLQFMFACI GVQLFLFLSH RGIYIVYKDG DVDNPMVKER VWQNSDFNFD NVLSAMMALF
     TVSTFEGWPA LLYKAIDSNG ENVGPVYNYR VEISIFFIIY IIIIAFFMMN IFVGFVIVTF
     QEQGEQEYKN CELDKNQRQC VEYALKARPL RRYIPKNPYQ YKFWYVVNST GFEYIMFVLI
     MLNTLCLAMQ HYGQSKLFND AMDIMNMVFT GVFTVEMVLK LIAFKPKIFV RKKERWLGYF
     SDAWNTFDSL IVIGSIVDVV LSEADPKPTE TVTTDESGNS EDSARISITF FRLFRVMRLV
     KLLSRGEGIR TLLWTFIKSF QALPYVALLI AMLFFIYAVI GMQVFGKVAM RDNNQINRNN
     NFQTFPQAVL LLFRCATGEA WQEIMLACLP GKRCDPESDY NPGEEYTCGS NFAIIYFISF
     YMLCAFLIIN LFVAVIMDNF DYLTRDWSIL GPHHLDEFKR IWSEYDPEAK GRIKHLDVVT
     LLRRIQPPLG FGKLCPHRVA CKRLVAMNMP LNSDGTVMFN ATLFALVRTA LKIKTEGNLE
     QANEELRAVI KKIWKKTSMK LLDQVVPPAG DDEVTVGKFY ATFLIQDYFR KFKKRKEQGL
     VGKYPAKNTT IALQAGLRTL HDIGPEIRRA ISCDLQDDEP EENNPEEEED VYKRNGALFG
     NHINHISSDR RDSFQQINTT HRPLHVQRPS IPSASDTEKN IYPQAGNSVY HNHHNHNSVG
     KHVPNSTNAN LNNANVSKVV HGKHTNFGNH EHRSENSYHS YSRTDHEKRR RPSSRRTRYY
     ETYIRSDSGD GRRPTICREE REAPDYCNDD HYLGEQEYFS GEEYYEEDSM LSGSRHIYNY
     HCRYHCHDSD FERPKGYHHP HGFFEEDDSQ ICFDTKRSPR RRLLPPTPTP NRRSSFNFEC
     LRRQSSQDDI PLSPNFHHRT ALPLHLMQQQ VMAVAGLDSS KAHKHSPSRS TRSWATPPAT
     PPNRDRTPYY TPLIQVDRAE STEHMNGSLP SLHRSSWYTD DPDISYRTFT PANLTVPNDF
     RHKHSDKQRS ADSLVEAVLI SEGLGRYAKD PKFVSATKHE IADACDMTID EMESAASNLL
     NGNISNGTNG DMFPILSRQD YELQDFGPGY SDEEPETGRY EEDLADEMIC ITSL
//
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