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Database: UniProt
Entry: A0A091V2V2_NIPNI
LinkDB: A0A091V2V2_NIPNI
Original site: A0A091V2V2_NIPNI 
ID   A0A091V2V2_NIPNI        Unreviewed;      1902 AA.
AC   A0A091V2V2;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   10-MAY-2017, entry version 18.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
DE   Flags: Fragment;
GN   ORFNames=Y956_11263 {ECO:0000313|EMBL:KFQ96635.1};
OS   Nipponia nippon (Crested ibis) (Ibis nippon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Pelecaniformes; Threskiornithidae;
OC   Nipponia.
OX   NCBI_TaxID=128390 {ECO:0000313|EMBL:KFQ96635.1, ECO:0000313|Proteomes:UP000053283};
RN   [1] {ECO:0000313|EMBL:KFQ96635.1, ECO:0000313|Proteomes:UP000053283}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_Y956 {ECO:0000313|EMBL:KFQ96635.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; KL410406; KFQ96635.1; -; Genomic_DNA.
DR   Proteomes; UP000053283; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   SMART; SM00015; IQ; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000053283};
KW   Ion channel {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000313|EMBL:KFQ96635.1};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053283};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    117    142       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    187    206       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    218    239       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    245    265       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    370    387       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    407    434       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    740    758       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    770    793       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    805    829       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    850    878       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    940    963       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1175   1193       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1214   1236       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1242   1262       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1291   1317       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1415   1438       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1496   1514       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1526   1544       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1551   1576       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1613   1641       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1715   1740       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      126    441       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      741    967       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      977   1169       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1173   1446       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1495   1750       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      438    469       {ECO:0000256|SAM:Coils}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:KFQ96635.1}.
FT   NON_TER    1902   1902       {ECO:0000313|EMBL:KFQ96635.1}.
SQ   SEQUENCE   1902 AA;  215420 MW;  08C16471BB55F647 CRC64;
     PGPENLRPFT PASLAAIEQR IAEAEALKVK RQQVELPEEE EIKPSSDLEA GKNLPLIYGD
     PPLELIGIPL EDLDPFYKDK KTFIVLNKGK SIFRFSATPA LYLLGPFHPI RRGAIKVLIH
     SYPCSLMFIM ITILTNCVFM TLSNPPAWSK NVEYTFTGIY TFESLIKILS RGFCIDDFTF
     LRDPWNWLDF MVISMAYITE FVDLGNISAL RTFRVLRALK TITVIPGLKT IVGALIQSVK
     KLSDVMILTV FCLSVFALIG LQLFMGNLRQ KCVRWPPLND TLLWDLGLDN DTLANAMLYG
     NFTDDVASNF TSNFTSNSTF DFEAYINDEA NFYFLEGALD ALLCGNSSDA GKCPEGYQCM
     KAGRNPNYGY TSYDTFSWAF LALFRLMTQD FWENLFQLTL RAAGKTYMIF FVVVIFLGSF
     YLINLILAVV AMAYAEQNDA TMLEEQQKEE EFQQLMEQLK KHQEEQEKMV GGKKPGRAPA
     AADYDQGTKE ALGEDRAVAA KLNALANHLL LAKTGNSREG LRDAASRPGS LVRWGVQVKR
     KGLQLLVSYC KLMSLVVARE DLSLLPRPCS KLWSQSSAQD GPGALFASLL SPVPCGDCGK
     LPMAVGTQLQ DRRSSSGSLP RNVAEKECDS DLNSDQDKAK DCNGQVVPKV VLERSATVIG
     VRAWLYHNHL TVSNQDGPGL EKRVGSAISV ISNTVEELEE AHQKCPSWWY KFAHTFLVWN
     CCPLWLKLKE FVKLVVMDPF VDLGITICIV LNTVFMAMEH YPMTEEFENV LTVGNLVFTG
     IFTAEMVLKL IALDPYEYFQ QGWNIFDSII VTLSLVELGL ANVQGLSVLR SFRLLRVFKL
     AKSWPTLNML IKIIGNSVGA LGNLTLVLAI IVFIFAVVGM QLFGKSYIEC VCKISHDCVL
     PRWHMNDFFH SFLIVFRILC GEWIETMWDC MEVAGQTMCL IVFMMVMVIG NLVVLNLFLA
     LLLSSFSADS LAASDDDGEM NNLQIAIGRI TKGIDFVKAS VLMLLRRLWK GKKVAPEEEQ
     EHSKRDNSVL NHVDTGQEPK SEYLDGVAGK EHFFMDELDH MNFINNPNLT VQVPIASEES
     DLYEETSTQS DTEDAKNPLS SDNASSLCST VDYKPPLPVE EEVAEDAEDS NEPEECFTEA
     CVKRFPCLYV DITSDRGKVW WNIRRTCFRI VEHDWFETFI VFMILLSSGA LAFEDIYIEQ
     RKVIRTVLEY ADKVFSYVFV IEMLLKWVAY GFKVYFTNAW CWLDFLIVDV SIISLTANWL
     GYSELGAIKS LRTLRALRPL RALSRFEGMR VVVNALLGAI PSIMNVLLVC LIFWLIFSIM
     GVNLFAGKYY RCINTTTGEL FEISVVNNKS DCMALLYTNE VRWVNVKVNF DNVGLGYLSL
     LQVATFKGWM DIMYAAVDSR EIEEQPAYEI NLYMYIYFVI FIIFGAFFTL NLFIGVIIDN
     FNQQKKKISK DIFMTEEQKK YYNAMKKLGS KKPQKPIPRP SNKFQGMVFD FVTKQVFDIT
     IMILICLNMV TMMVETDDQS ELKTSVLYKI NLVFIVIFTG ECVLKMFALR YYYFTIGWNI
     FDFVVVILSI LGIVLSDIIE KYFVSPTLFR VIRLARIGRV LRLIRGAKGI RTLLFALMMS
     LPALFNIGLL LFLVMFIYSI FGMSNFAYVK KEAGIDDIFN FETFGNSIIC LFQITTSAGW
     DGLLSPILNS GPPDCDPDLE NPGSSVKGDC GNPSIGIFFF CSYIIISFLI VVNMYIAIIL
     ENFNVATEES SEPLCEDDFE MFYETWEKFD PDATQFIAYS TLSDFVDTLQ EPLKIPKPNK
     IKLITMDLPM VAGDKIHCLD ILFALTKEVL GDSGEMDALK ATMEEKFMAA NPSKVSYEPI
     TTTLKRKHEE VCATKIQRAF RRYLLRRSVK QASYMYRHSK DE
//
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