ID A0A091VI91_OPIHO Unreviewed; 775 AA.
AC A0A091VI91;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Metabotropic glutamate receptor 2 {ECO:0000313|EMBL:KFR02824.1};
DE Flags: Fragment;
GN ORFNames=N306_12223 {ECO:0000313|EMBL:KFR02824.1};
OS Opisthocomus hoazin (Hoatzin) (Phasianus hoazin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Opisthocomiformes; Opisthocomidae;
OC Opisthocomus.
OX NCBI_TaxID=30419 {ECO:0000313|EMBL:KFR02824.1, ECO:0000313|Proteomes:UP000053605};
RN [1] {ECO:0000313|EMBL:KFR02824.1, ECO:0000313|Proteomes:UP000053605}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N306 {ECO:0000313|EMBL:KFR02824.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000256|ARBA:ARBA00007242}.
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DR EMBL; KK734012; KFR02824.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091VI91; -.
DR STRING; 30419.A0A091VI91; -.
DR PhylomeDB; A0A091VI91; -.
DR Proteomes; UP000053605; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd06375; PBP1_mGluR_groupII; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR001458; GPCR_3_mGluR2.
DR InterPro; IPR000162; GPCR_3_mtglu_rcpt.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24060; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR24060:SF147; METABOTROPIC GLUTAMATE RECEPTOR 2; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01052; MTABOTROPC2R.
DR PRINTS; PR00593; MTABOTROPICR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00979; G_PROTEIN_RECEP_F3_1; 1.
DR PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:KFR02824.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053605};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 539..562
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 578..598
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 652..673
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 701..720
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 732..754
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 540..775
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFR02824.1"
FT NON_TER 775
FT /evidence="ECO:0000313|EMBL:KFR02824.1"
SQ SEQUENCE 775 AA; 87309 MW; 629DE1222992A96D CRC64;
KKEISTDGDL VIGGLFPVHE KGVGSEDCGK INEHRGIQRL EAMLFALDEI NKDGSILPGV
RLGAHILDTC SKDTYALEQS LDFVRASLTR VDGSEHICPD GSYAVHDDVP TAITGVIGGS
YSDVSIQVAN LLRLFQIPQI SYASTSAKLS DKSRYDYFAR TVPPDFYQAK AMAEILRFFN
WTYVSTVASE GDYGETGIEA FEQEARMRNI CIATSEKVGR SMNKKTYDGV VRALLQKPNA
RVVVLFTRSE DARELLTAAQ RANVSFMWVA SDGWGALESV VAGSEAVAEG AITIELAAYP
IKEFATYFRN LHPYNNSRNP WFREFWEQKF KCSFHTQDCS WYSLKTGKFE PESKITFVVN
AVYAMAHSLH NMHQALCPNA TKLCDAMKPV NGKRFYKDFM LNVNFDAPFR PADTKSVVRF
DRYGDGIGRY NIFNYHHVDG RYRYQKVGYW AEGLILNTSL IPWAEMSIPV SQCSDPCKKN
EIKSMQPGDI CCWICIPCQP YEYLLDEFTC MDCGLGYWPN ETLNGCYELP QEYIRWKDVW
AIGPVTISCL GFISTLFVFG VFMKNNDTPI VKASGRELCY ILLTGVLMCY SMTFIFIAKP
STEVCTLRRL GLGTSFAVCY SALLTKTNRI ARIFSGVKEG VQRPRFISPT SQVVICMALI
SCQLIIVIIW LLVETPGTGK ETEPDKRYIV TLKCNNRDSN MLISLTYNVL LIVLCTVYAF
KTRKCPENFN EAKFIGFTMY TTCIIWLAFL PIFYVTSSDY RVQTTTMCIS VSLSG
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