GenomeNet

Database: UniProt
Entry: A0A091VM10_NIPNI
LinkDB: A0A091VM10_NIPNI
Original site: A0A091VM10_NIPNI 
ID   A0A091VM10_NIPNI        Unreviewed;      2317 AA.
AC   A0A091VM10;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   25-OCT-2017, entry version 20.
DE   RecName: Full=Voltage-dependent N-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   ORFNames=Y956_15869 {ECO:0000313|EMBL:KFQ90733.1};
OS   Nipponia nippon (Crested ibis) (Ibis nippon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Pelecaniformes; Threskiornithidae;
OC   Nipponia.
OX   NCBI_TaxID=128390 {ECO:0000313|EMBL:KFQ90733.1, ECO:0000313|Proteomes:UP000053283};
RN   [1] {ECO:0000313|EMBL:KFQ90733.1, ECO:0000313|Proteomes:UP000053283}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_Y956 {ECO:0000313|EMBL:KFQ90733.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1B
CC       gives rise to N-type calcium currents. N-type calcium channels
CC       belong to the 'high-voltage activated' (HVA) group and are blocked
CC       by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-
CC       IIIA (omega-Aga-IIIA). They are however insensitive to
CC       dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing alpha-1B subunit may play a role in
CC       directed migration of immature neurons.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; KL409630; KFQ90733.1; -; Genomic_DNA.
DR   Proteomes; UP000053283; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005447; VDCC_N_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF161; PTHR10037:SF161; 2.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01631; NVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000053283};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053283};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    126    146       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    158    178       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    213    235       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    289    310       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    322    344       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    462    482       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    488    505       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    587    609       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    665    687       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1131   1150       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1170   1191       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1203   1221       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1264   1286       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1376   1401       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1457   1475       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1487   1510       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1579   1606       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1666   1690       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1828   1862       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED      696    723       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2317 AA;  262729 MW;  E42997BA667E1563 CRC64;
     MARFGDDLPT RYGGGGPAGA GRGSSRQGGP QAGQRMYKQS MAQRARTMAL YNPIPVKQNC
     FTVNRSLFIF SEDNVIRKYA KRITEWPYPF REATIIANCI VLALEQHLPD GDKTPMSERL
     DDTEPYFIGI FCFEAGIKII ALGFVFHKGS YLRNGWNVMD FVVVLTGILA TAGTDFDLRT
     LRAVRVLRPL KLVSGIPSLQ VVLKSIMKAM VPLLQIGLLL FFAIVMFAII GLEFYMGKFH
     KTCFSNETGD EVGDFPCGEE PPARQCESGT TCREYWQGPN YGITNFDNIL FAVLTVFQCI
     TMEGWTDILY NTNDAAGNTW NWLYFIPLII IGSFFMLNLV LGVLSGEFAK ERERVENRRA
     FLKLRRQQQI ERELNGYLEW IFKAEEVMLA EEDKNAEEKS PLDVLKRAAI KKSKNDLIHA
     EEGSPFARAS LKSGKNESSS YFRRKEKMFR FFIRRMVKAQ SFYWIVLCVV ALNTLCVAMV
     HYDQPEKLTT ALYFAEFVFL GLFLTEMSLK MYGLGPRNYF HSSFNCFDFG VIVGSIFEVI
     WAAVKPGTSF GISVLRALRL LRIFKVTKYW NSLRNLVVSL LNSMKSIISL LFLLFLFIVV
     FALLGMQLFG GQFNFQDETP TTNFDTFPAA ILTVFQILTG EDWNAVMYHG IESQGGVRSG
     MFSSIYFIVL TLFGNYTLLN VFLAIAVDNL ANAQELTKDE EEMEEATNQK LALQKAKEVA
     EVSPMSAANI SIAAKQQNSS KSKSVWEQRT SQIRMHNFRA SCEALYNELD PEERVRYATT
     LHIRPDMKTH LDRPLVVEPR GEGRNNISKL SPVDVQEVEQ TKVSSSDGAE APRKHHRHRD
     KDKLGEQEKG DVTKDENGES GVNNKEERHR QHRSRSKEVE GGSKEGKSDR NRGQEGGKRH
     HRRGSVEEGA EKEHRRHRTH RHSAERQGKE GNGTINGARS ERRSRHRGGS RSGNREGEPG
     SKGENGEEPH RRHRFRNRAL STYDSVEKEN GEKEGEAGEK EHRNHQPKEN QCEIEASGSV
     SVPVHTLPST YLQKVPEQPE DADNQKNVTR MIQPPLDKTT TVNIPVTITA PPGETTVIPM
     NNVEFESKTE EKKDVDDLTK NGPKPILPYS SMFILSPTNP IRRLFHYIVN LRYFEMVILI
     VIALSSIALA AEDPVQAESP RNDALKYLDY IFTGVFTFEM VIKMIDLGLL LHPGSYFRDL
     WNILDFIVVS GALVAFAFSG TKGKDINTIK SLRVLRVLRP LKTIKRLPKL KAVFDCVVNS
     LKNVLNILIV YMLFMFIFAV IAVQLFKGRF FYCTDESKEL EKDCRGQYLD YEKNEVEAQP
     REWKKYEFHY DNVLWALLTL FTVSTGEGWP TVLKHSVDAT YEEQGPSPGY RMEMSIFYVV
     YFVVFPFFFV NIFVALIIIT FQEQGDKVMS ECSLEKNERA CIDFAISAKP LTRYMPQNKQ
     SFQYKMWKFV VSPPFEYFIM VMIALNTIVL MMKFYDAPEA YEEMLKCLNI VFTSMFSMEC
     VLKIIAFGVL NYFRDAWNVF DFVTVLGSIT DILVTEIADN FINLSFLRLF RAARLIKLLR
     QGYTIRILLW TFVQSFKALP YVCLLIAMLF FIYAIIGMQV FGNIALDDET SINRHNNFRT
     FLQALMLLFR SATGEAWHEI MLSCLSNRAC DPLSGLTKNE CGSDFAYFYF VSFIFLCSFL
     MLNLFVAVIM DNFEYLTRDS SILGPHHLDE FVRVWAEYDP AACCRIHYKD MYNLLRVIAP
     PLGLGKKCPH RVAYKRLVRM NMPISPEDLT VHFTSTLMAL IRTALEIKLA SGGVKQHQCD
     AELRKEISLV WPNLSQKTLD LLVPPHKPDE MTVGKVYAAL MIFDFYKQNK NSREQVHQPP
     GGLCQPGPVS LFHPLKATLE QTQPAAFNNA KAFLRQKSSA SLNNGGALPA PEGGIKESSS
     WGTQRTQDVF YETRTPAFER GHSEEIPIER VVEMREISPT LANGEHQPGL ESQGRAASMP
     RLAAETQRSK ARSPGSYLAP IPDTSPMKRS VSTLTPQRPH AMHLYEYSLE RMPPEQGHHH
     HHHRCHRRKE KKQKSLDRSP HQLADGEAVA QSGESSSKDK KHERGRSQER KQHSSSSSEK
     QRFYSCDRYG SRDRSQPKSA DQSRPTSPNG GPEQGPHRQG SGSVNGSPLL STSGASTPCR
     GRRQLPQTPL TPRPSITYKT ANSSPVHFTS FQTGLPTFSP GRLSRGLSEH NALLRGDQQP
     PPPAVARIGS DPYLGHRDDT DSPYRAVPED TLTFEEAVAT NSGRSSRTSY VSSLTSQSHQ
     IRRVPNGYHY TLGLNTGPGT GTRGRSYYHE ADEDDWC
//
DBGET integrated database retrieval system