UniProt: A0A091VYL9

Database: UniProt
Entry: A0A091VYL9_OPIHO

LinkDB:  A0A091VYL9_OPIHO 
Original site:  A0A091VYL9_OPIHO

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Ontology (4)   
   GO (4)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (10)   
   InterPro (6)   
   Pfam (2)   
   PROSITE (1)   
   SMART (1)   
All databases (16)   

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ID   A0A091VYL9_OPIHO        Unreviewed;       512 AA.
AC   A0A091VYL9;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 38.
DE   RecName: Full=Cystathionine beta-synthase {ECO:0000256|ARBA:ARBA00012041, ECO:0000256|RuleBase:RU361204};
DE            EC=4.2.1.22 {ECO:0000256|ARBA:ARBA00012041, ECO:0000256|RuleBase:RU361204};
DE   Flags: Fragment;
GN   ORFNames=N306_09199 {ECO:0000313|EMBL:KFR08472.1};
OS   Opisthocomus hoazin (Hoatzin) (Phasianus hoazin).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Opisthocomiformes; Opisthocomidae;
OC   Opisthocomus.
OX   NCBI_TaxID=30419 {ECO:0000313|EMBL:KFR08472.1, ECO:0000313|Proteomes:UP000053605};
RN   [1] {ECO:0000313|EMBL:KFR08472.1, ECO:0000313|Proteomes:UP000053605}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N306 {ECO:0000313|EMBL:KFR08472.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-homocysteine + L-serine = H2O + L,L-cystathionine;
CC         Xref=Rhea:RHEA:10112, ChEBI:CHEBI:15377, ChEBI:CHEBI:33384,
CC         ChEBI:CHEBI:58161, ChEBI:CHEBI:58199; EC=4.2.1.22;
CC         Evidence={ECO:0000256|ARBA:ARBA00001175,
CC         ECO:0000256|RuleBase:RU361204};
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|RuleBase:RU361204};
CC   -!- SIMILARITY: Belongs to the cysteine synthase/cystathionine beta-
CC       synthase family. {ECO:0000256|ARBA:ARBA00007103,
CC       ECO:0000256|RuleBase:RU361204}.
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DR   EMBL; KK734466; KFR08472.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A091VYL9; -.
DR   STRING; 30419.A0A091VYL9; -.
DR   PhylomeDB; A0A091VYL9; -.
DR   UniPathway; UPA00136; -.
DR   Proteomes; UP000053605; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004122; F:cystathionine beta-synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006535; P:cysteine biosynthetic process from serine; IEA:UniProtKB-UniRule.
DR   GO; GO:0019343; P:cysteine biosynthetic process via cystathionine; IEA:UniProtKB-UniRule.
DR   CDD; cd01561; CBS_like; 1.
DR   CDD; cd04608; CBS_pair_CBS; 1.
DR   Gene3D; 3.40.50.1100; -; 2.
DR   Gene3D; 3.10.580.10; CBS-domain; 1.
DR   InterPro; IPR046353; CBS_C.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR005857; Cysta_beta_synth.
DR   InterPro; IPR001926; TrpB-like_PALP.
DR   InterPro; IPR036052; TrpB-like_PALP_sf.
DR   NCBIfam; TIGR01137; cysta_beta; 1.
DR   PANTHER; PTHR10314; CYSTATHIONINE BETA-SYNTHASE; 1.
DR   PANTHER; PTHR10314:SF247; CYSTATHIONINE BETA-SYNTHASE; 1.
DR   Pfam; PF00571; CBS; 1.
DR   Pfam; PF00291; PALP; 1.
DR   SMART; SM00116; CBS; 1.
DR   SUPFAM; SSF54631; CBS-domain pair; 1.
DR   SUPFAM; SSF53686; Tryptophan synthase beta subunit-like PLP-dependent enzymes; 1.
DR   PROSITE; PS51371; CBS; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU361204};
KW   CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703,
KW   ECO:0000256|RuleBase:RU361204};
KW   Cysteine biosynthesis {ECO:0000256|ARBA:ARBA00023192,
KW   ECO:0000256|RuleBase:RU361204};
KW   Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW   Lyase {ECO:0000256|RuleBase:RU361204};
KW   Pyridoxal phosphate {ECO:0000256|RuleBase:RU361204};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053605}.
FT   DOMAIN          379..439
FT                   /note="CBS"
FT                   /evidence="ECO:0000259|PROSITE:PS51371"
FT   REGION          1..36
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFR08472.1"
FT   NON_TER         512
FT                   /evidence="ECO:0000313|EMBL:KFR08472.1"
SQ   SEQUENCE   512 AA;  56600 MW;  E6A3992D0FE61D2D CRC64;
     KEREWISPDT PSKCTWKLGK PPSASPHHHI TPSEPPKILP NILDKVGNTP MVRINKIGKH
     YGLKCELLAK CEYFNAGGSV KDRICLRMVE EAEKAGILKP GHTIIEPTSG NTGIGLALAA
     AVKGYRCIIV MPEKMSMEKV DVLRALGAEI VRTPTTARFD SPESHVGVAW RLKNEIPNAH
     ILDQYRNANN PLTHYDTTAE EILQQCEGKI DMLVATAGTG GTITGISRKL KEKCPGCKII
     GVDPEGSILA EPEELNKTDK TMYEVEGIGY DFIPTVLDRS VMDQWYKSND EESFTLARMM
     IREEGLLCGG SSGSAMSVAV KAAKELKEGQ RCVVILPDSI RNYMSKFLSD KWMIQKGFMK
     EGDLVKKPWW WNISVQELSL SAPLTVLPTV TCAKTVEILR EKGFDQVPVV DESGVILGMV
     TLGNMLSSLL AGKVQPSDEV GKVIYKQFKQ INLKDNLGKL SHILETDHFA LVVHEQIQYH
     TDGSSSKRQM VFGIVTAIDL LNFVTARERV GK
//

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