ID   A0A091W018_NIPNI        Unreviewed;       431 AA.
AC   A0A091W018;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=Lipase member H {ECO:0000313|EMBL:KFQ95188.1};
DE   Flags: Fragment;
GN   ORFNames=Y956_12518 {ECO:0000313|EMBL:KFQ95188.1};
OS   Nipponia nippon (Crested ibis) (Ibis nippon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Pelecaniformes; Threskiornithidae;
OC   Nipponia.
OX   NCBI_TaxID=128390 {ECO:0000313|EMBL:KFQ95188.1, ECO:0000313|Proteomes:UP000053283};
RN   [1] {ECO:0000313|EMBL:KFQ95188.1, ECO:0000313|Proteomes:UP000053283}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_Y956 {ECO:0000313|EMBL:KFQ95188.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.
CC       {ECO:0000256|ARBA:ARBA00010701, ECO:0000256|RuleBase:RU004262}.
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DR   EMBL; KL410274; KFQ95188.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A091W018; -.
DR   eggNOG; ENOG502QUQT; Eukaryota.
DR   Proteomes; UP000053283; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0052689; F:carboxylic ester hydrolase activity; IEA:InterPro.
DR   GO; GO:0016298; F:lipase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR   CDD; cd00707; Pancreat_lipase_like; 1.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR013818; Lipase.
DR   InterPro; IPR016272; Lipase_LIPH.
DR   InterPro; IPR033906; Lipase_N.
DR   InterPro; IPR000734; TAG_lipase.
DR   PANTHER; PTHR11610; LIPASE; 1.
DR   PANTHER; PTHR11610:SF186; LIPASE H-RELATED; 1.
DR   Pfam; PF00151; Lipase; 1.
DR   PIRSF; PIRSF000865; Lipoprotein_lipase_LIPH; 1.
DR   PRINTS; PR00821; TAGLIPASE.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|PIRSR:PIRSR000865-2};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR000865-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053283};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT   DOMAIN          22..311
FT                   /note="Lipase"
FT                   /evidence="ECO:0000259|Pfam:PF00151"
FT   ACT_SITE        139
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000865-1"
FT   ACT_SITE        163
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000865-1"
FT   ACT_SITE        233
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000865-1"
FT   BINDING         177
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000865-2"
FT   BINDING         179
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000865-2"
FT   BINDING         182
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000865-2"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFQ95188.1"
FT   NON_TER         431
FT                   /evidence="ECO:0000313|EMBL:KFQ95188.1"
SQ   SEQUENCE   431 AA;  48379 MW;  4321A709480D150C CRC64;
     SDPGETCPAF TALSISNALI GTDLKVKLLL YTRQNPNCAE ELNSTSSTYL DVTKKTTFII
     HGYRLTGSAP VWIPDLVHLL LSVEDMNVIL VDWNQGATTL IYSNASRNCK KVAEILKKLI
     DEMLVDGASL DSLHMIGVSL GAHISGFVGQ MFDGTLGRIT GLDPAGPLYR GKPPTERLDP
     TDAQFVDVIH SDTDGLGYTE ALGHIDFYPN GGTDQPGCPL TIFSGLQYFK CDHQRSVFLF
     MSSLKQSCNI TAYPCDSYRN YRNGKCTSCE TFWPMPCPIL GYYAHKWKSY LTQQSHPVTS
     MFFDTADKEP FCIYHYFVDI ITWNKNTRRG TFSIVLADET GKKAESKVNP EAAAFQRYNQ
     ITLLMGFDQD FENVERISLT FSTGSVIGPK FKLRILQMRF RSLTNPERPQ LCRYDLVLME
     NTKKTFKPIP C
//