ID A0A091W1N3_NIPNI Unreviewed; 688 AA.
AC A0A091W1N3;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=Guanylate cyclase soluble subunit alpha-1 {ECO:0000256|ARBA:ARBA00040514};
DE EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202};
DE AltName: Full=Soluble guanylate cyclase large subunit {ECO:0000256|ARBA:ARBA00042184};
GN ORFNames=Y956_01045 {ECO:0000313|EMBL:KFR08673.1};
OS Nipponia nippon (Crested ibis) (Ibis nippon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Pelecaniformes; Threskiornithidae;
OC Nipponia.
OX NCBI_TaxID=128390 {ECO:0000313|EMBL:KFR08673.1, ECO:0000313|Proteomes:UP000053283};
RN [1] {ECO:0000313|EMBL:KFR08673.1, ECO:0000313|Proteomes:UP000053283}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_Y956 {ECO:0000313|EMBL:KFR08673.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
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DR EMBL; KL411536; KFR08673.1; -; Genomic_DNA.
DR RefSeq; XP_009473026.1; XM_009474751.1.
DR AlphaFoldDB; A0A091W1N3; -.
DR STRING; 128390.A0A091W1N3; -.
DR GeneID; 104021238; -.
DR KEGG; nni:104021238; -.
DR CTD; 2982; -.
DR eggNOG; KOG4171; Eukaryota.
DR OrthoDB; 2898719at2759; -.
DR Proteomes; UP000053283; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 6.10.250.780; -; 1.
DR Gene3D; 3.90.1520.10; H-NOX domain; 1.
DR Gene3D; 3.30.450.260; Haem NO binding associated domain; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR038158; H-NOX_domain_sf.
DR InterPro; IPR011645; HNOB_dom_associated.
DR InterPro; IPR042463; HNOB_dom_associated_sf.
DR InterPro; IPR024096; NO_sig/Golgi_transp_ligand-bd.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR45655:SF4; GUANYLATE CYCLASE SOLUBLE SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45655; GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07701; HNOBA; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF111126; Ligand-binding domain in the NO signalling and Golgi transport; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134};
KW Reference proteome {ECO:0000313|Proteomes:UP000053283}.
FT DOMAIN 479..606
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT COILED 424..451
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 688 AA; 77875 MW; 03D0D51B2C0273B6 CRC64;
MFCTKLKDLK ITGECPFSLL TQSHVTEEHD KDCTENSSRA ALPICKEVHE KDAQGNLPQR
KTSRSRVYLH TLTESICKLI FPEFERLNLA LQRTLAKHRI KETRKNGDRE DFEKIISDHA
NAAGVPVESL RECLGEELFK ICYEEDEHIL GVIGGTLKDF LNSFTTLLKQ SGHSQEAGKK
DRLEDASILC LEKDQDFLNV YYFFPKKITS LILPGIIKAA AHILYETEVE VMLMPSCFHN
DCTEFANQPY LLYSIQVKSA KPSLSPCKPQ SSLVIPASVF CKTFPFHFMF DKDMSVLQIG
NGIRRLLTRR EFQAKPNFEE YFEILTPKVS CTFSGIMTML NMQFTVRVRR WDNTDMKSSM
VMDLKGQMIY IFESSAILFL GSPCVDRLED FTGRGLYLSD IPIHNALRDV VLIGEQARAQ
DGLKKRLGKL KATLEQAHQA LEEEKKKTVD LLFSIFPGEV AQQLWQGQVV QAKKFNNVTM
LFSDIVGFTA ICSQCSPMQV ITMLNELYTR FDYQCGELDV YKVETIGDAY CVAGGLHKES
ETHAVQIALM ALKMMELSDE VVSPHGEPIK MRIGLHSGSV FAGVVGVKMP RYCLFGNNVT
LANKFESCSI PRKINVSPTT YRLLKEYPGF VFTPRSREEL PPNFPSDIPG ICYFLDAYIQ
GTNSQTWFQK RDLGDGNANF LGEETGID
//
