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Database: UniProt
Entry: A0A091W215_OPIHO
LinkDB: A0A091W215_OPIHO
Original site: A0A091W215_OPIHO 
ID   A0A091W215_OPIHO        Unreviewed;       567 AA.
AC   A0A091W215;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   24-JAN-2024, entry version 34.
DE   SubName: Full=Complement component C8 alpha chain {ECO:0000313|EMBL:KFR09479.1};
DE   Flags: Fragment;
GN   ORFNames=N306_02463 {ECO:0000313|EMBL:KFR09479.1};
OS   Opisthocomus hoazin (Hoatzin) (Phasianus hoazin).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Opisthocomiformes; Opisthocomidae;
OC   Opisthocomus.
OX   NCBI_TaxID=30419 {ECO:0000313|EMBL:KFR09479.1, ECO:0000313|Proteomes:UP000053605};
RN   [1] {ECO:0000313|EMBL:KFR09479.1, ECO:0000313|Proteomes:UP000053605}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N306 {ECO:0000313|EMBL:KFR09479.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the complement C6/C7/C8/C9 family.
CC       {ECO:0000256|ARBA:ARBA00009214}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR   EMBL; KK734535; KFR09479.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A091W215; -.
DR   STRING; 30419.A0A091W215; -.
DR   PhylomeDB; A0A091W215; -.
DR   Proteomes; UP000053605; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005579; C:membrane attack complex; IEA:UniProtKB-KW.
DR   GO; GO:0006957; P:complement activation, alternative pathway; IEA:UniProtKB-KW.
DR   GO; GO:0006958; P:complement activation, classical pathway; IEA:UniProtKB-KW.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR   CDD; cd00112; LDLa; 1.
DR   Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 1.
DR   Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 1.
DR   InterPro; IPR048831; C8A_B_C6_EGF-like.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR036055; LDL_receptor-like_sf.
DR   InterPro; IPR023415; LDLR_class-A_CS.
DR   InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR   InterPro; IPR001862; MAC_perforin.
DR   InterPro; IPR020864; MACPF.
DR   InterPro; IPR020863; MACPF_CS.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   PANTHER; PTHR45742; COMPLEMENT COMPONENT C6; 1.
DR   PANTHER; PTHR45742:SF1; COMPLEMENT COMPONENT C8 ALPHA CHAIN; 1.
DR   Pfam; PF21195; C8A_B_C6_EGF-like; 1.
DR   Pfam; PF00057; Ldl_recept_a; 1.
DR   Pfam; PF01823; MACPF; 1.
DR   PRINTS; PR00764; COMPLEMENTC9.
DR   PRINTS; PR01705; TSP1REPEAT.
DR   SMART; SM00192; LDLa; 1.
DR   SMART; SM00457; MACPF; 1.
DR   SUPFAM; SSF57424; LDL receptor-like module; 1.
DR   SUPFAM; SSF82895; TSP-1 type 1 repeat; 1.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS01209; LDLRA_1; 1.
DR   PROSITE; PS50068; LDLRA_2; 1.
DR   PROSITE; PS00279; MACPF_1; 1.
DR   PROSITE; PS51412; MACPF_2; 1.
DR   PROSITE; PS50092; TSP1; 1.
PE   3: Inferred from homology;
KW   Complement alternate pathway {ECO:0000256|ARBA:ARBA00023162};
KW   Complement pathway {ECO:0000256|ARBA:ARBA00022875};
KW   Cytolysis {ECO:0000256|ARBA:ARBA00022852};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Immunity {ECO:0000256|ARBA:ARBA00022859};
KW   Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW   Membrane attack complex {ECO:0000256|ARBA:ARBA00023058};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053605};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          118..481
FT                   /note="MACPF"
FT                   /evidence="ECO:0000259|PROSITE:PS51412"
FT   REGION          534..557
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        534..551
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        79..91
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        98..113
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFR09479.1"
FT   NON_TER         567
FT                   /evidence="ECO:0000313|EMBL:KFR09479.1"
SQ   SEQUENCE   567 AA;  64026 MW;  9A0F2F334AA29068 CRC64;
     RSSRDVNSPA PIDCQLSQWS GWTDCFPCQE KKVRLHRNVF IYLQMLGQPA GFAGQRCTGH
     LWGEQACRAE TTCTGPPGCG QDFRCEETGR CIKRHLVCNG ERDCRDGSDE ENCEDEDIES
     PCEHLFPIPG SEKAAQGYNI LTQEESQYIY DPYFFGGHCE YVYNGEWREL KYDAACEHLY
     YGDDEKYFRK PYNFHIYQFL AYADSGFTFE FYDDSKDLLD ALKSDKFKTK GFTIGIGPGE
     SAFQLDLGFT LSGGKGSLKN FTQYTAKEVG FIRGTTKVQT AHFKMRRDNI VLDEDVLLSL
     RELPDTYNYG MYAKFINDYG THFMTSGTMG GVFEYILVIN KEEMRRKDIS AEEISACIGW
     SLGLTVRETE VQLEASVSSS DCAKKGFLKT DAETHSAVVE DIIPRIRGGD TSYSGGLLNS
     WDGNMYRHWG RSLKYNPAVI DFELQPIHEI LRRSNLGNME TKRQNLKRAL DDYLLEFNAC
     RCGPCQNNGE PVLVGDTCFC QCRPGDGGPA CEQTRRQGGE TDGRWSCWSP WGPCQSGTAR
     RSRQCNNPAP QRGGQPCAGR DLQNRAC
//
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