ID   A0A091W630_OPIHO        Unreviewed;       729 AA.
AC   A0A091W630;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=Seprase {ECO:0000313|EMBL:KFR10303.1};
DE   Flags: Fragment;
GN   ORFNames=N306_04105 {ECO:0000313|EMBL:KFR10303.1};
OS   Opisthocomus hoazin (Hoatzin) (Phasianus hoazin).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Opisthocomiformes; Opisthocomidae;
OC   Opisthocomus.
OX   NCBI_TaxID=30419 {ECO:0000313|EMBL:KFR10303.1, ECO:0000313|Proteomes:UP000053605};
RN   [1] {ECO:0000313|EMBL:KFR10303.1, ECO:0000313|Proteomes:UP000053605}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N306 {ECO:0000313|EMBL:KFR10303.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004401};
CC       Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
CC       Cell projection, invadopodium membrane {ECO:0000256|ARBA:ARBA00004341};
CC       Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004341}.
CC       Cell projection, lamellipodium membrane
CC       {ECO:0000256|ARBA:ARBA00004485}; Single-pass type II membrane protein
CC       {ECO:0000256|ARBA:ARBA00004485}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KK734692; KFR10303.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A091W630; -.
DR   STRING; 30419.A0A091W630; -.
DR   MEROPS; S09.007; -.
DR   PhylomeDB; A0A091W630; -.
DR   Proteomes; UP000053605; Unassembled WGS sequence.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0031258; C:lamellipodium membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 2.140.10.30; Dipeptidylpeptidase IV, N-terminal domain; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR002471; Pept_S9_AS.
DR   InterPro; IPR001375; Peptidase_S9.
DR   InterPro; IPR002469; Peptidase_S9B_N.
DR   PANTHER; PTHR11731:SF136; PROLYL ENDOPEPTIDASE FAP; 1.
DR   PANTHER; PTHR11731; PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED; 1.
DR   Pfam; PF00930; DPPIV_N; 1.
DR   Pfam; PF00326; Peptidase_S9; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
DR   PROSITE; PS00708; PRO_ENDOPEP_SER; 1.
PE   4: Predicted;
KW   Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053605}.
FT   DOMAIN          75..441
FT                   /note="Dipeptidylpeptidase IV N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00930"
FT   DOMAIN          523..726
FT                   /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00326"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFR10303.1"
FT   NON_TER         729
FT                   /evidence="ECO:0000313|EMBL:KFR10303.1"
SQ   SEQUENCE   729 AA;  83970 MW;  B4CF59095BF2BFAC CRC64;
     VVNTDDGSRA LTLEDYLNGN FQYKTFFPYW VSDNEYLHQS AEDDIILYNV DMNYPTTIMT
     NSTMKQVNAS NYVLSSDKYF IALESNYSKL WRYSYTASYH IYDLIYGGFV TENQLPHKIQ
     YISWSPVGHK LVYVYQNNIY LKQSPREVPI KLTSDGKQNE IFNGIPDWVY EEEMLATKYA
     LWWSPSGKYL AYVQFNDSDI PVIEYSYFGE DQYPRKIIIP YPKAGAKNPT VKVFIVDTIN
     AEVFGPKEVP VPAVVASSDH YFTWLTWVTD TRICVQWLKR IQNFSVLAIC DFKENSNTWD
     CPENQQHIEE SQTGWAGGFF VSAPYFTSDS SSYYKIFSDK SGYKHIHYIN GSVENAVQIT
     SGEWEAIYIF RVTNDAIFYS SNEFEGYPGR RNIYKISIGS KPIRKQCITC NLRKERCQYY
     TARFSEHSKY YALICYGPGI PISALFENHG DRELRVLEDN WELQSALQEI KLPKEEINKL
     EVDGITLWYK MLLPPQFDRS KKYPLLIQVY GGPCSQNVKE TFSISWITYL ASKEGIIIAL
     VDGRGTAYQG DKILHAVYRR LGVYEVEDQI SAVKKFIEMG FIDEKRIAIW GWSYGGYVTS
     LALGSGSGVF KCGMAVAPVS SWEYYASIYT ERFMGLPVES DNLEHYKNST VMARAKNFQN
     VDYLLIHGTA DDNVHFQNSA QIAKALVNAQ VDFQAMWYTD QNHGIPGLSS KHLYTHMTNF
     LKKCFSLSE
//