ID   A0A091W6S4_NIPNI        Unreviewed;       522 AA.
AC   A0A091W6S4;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   RecName: Full=NEDD8-activating enzyme E1 regulatory subunit {ECO:0000256|ARBA:ARBA00015407};
DE   AltName: Full=Amyloid protein-binding protein 1 {ECO:0000256|ARBA:ARBA00033048};
DE   Flags: Fragment;
GN   ORFNames=Y956_02614 {ECO:0000313|EMBL:KFQ97465.1};
OS   Nipponia nippon (Crested ibis) (Ibis nippon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Pelecaniformes; Threskiornithidae;
OC   Nipponia.
OX   NCBI_TaxID=128390 {ECO:0000313|EMBL:KFQ97465.1, ECO:0000313|Proteomes:UP000053283};
RN   [1] {ECO:0000313|EMBL:KFQ97465.1, ECO:0000313|Proteomes:UP000053283}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_Y956 {ECO:0000313|EMBL:KFQ97465.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Protein modification; protein neddylation.
CC       {ECO:0000256|ARBA:ARBA00005032}.
CC   -!- SIMILARITY: Belongs to the ubiquitin-activating E1 family. ULA1
CC       subfamily. {ECO:0000256|ARBA:ARBA00006868}.
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DR   EMBL; KL410586; KFQ97465.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A091W6S4; -.
DR   STRING; 128390.A0A091W6S4; -.
DR   eggNOG; KOG2016; Eukaryota.
DR   UniPathway; UPA00885; -.
DR   Proteomes; UP000053283; Unassembled WGS sequence.
DR   GO; GO:0019781; F:NEDD8 activating enzyme activity; IEA:InterPro.
DR   GO; GO:0045116; P:protein neddylation; IEA:UniProtKB-UniPathway.
DR   CDD; cd01493; APPBP1_RUB; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   InterPro; IPR030667; APP-BP1.
DR   InterPro; IPR045886; ThiF/MoeB/HesA.
DR   InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR   InterPro; IPR035985; Ubiquitin-activating_enz.
DR   PANTHER; PTHR10953:SF29; NEDD8-ACTIVATING ENZYME E1 REGULATORY SUBUNIT; 1.
DR   PANTHER; PTHR10953; UBIQUITIN-ACTIVATING ENZYME E1; 1.
DR   Pfam; PF00899; ThiF; 1.
DR   PIRSF; PIRSF039099; APP-BP1; 1.
DR   SUPFAM; SSF69572; Activating enzymes of the ubiquitin-like proteins; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000053283}.
FT   DOMAIN          6..518
FT                   /note="THIF-type NAD/FAD binding fold"
FT                   /evidence="ECO:0000259|Pfam:PF00899"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFQ97465.1"
FT   NON_TER         522
FT                   /evidence="ECO:0000313|EMBL:KFQ97465.1"
SQ   SEQUENCE   522 AA;  58925 MW;  2B19FF22EF4BC707 CRC64;
     FPSQCRLWGD HGQEALESAH VCVINATATG TEILKNLVLP GIGSFTIVDG NQVSGEDVGN
     NFFLQKSQIG QNRAQSATEL LQELNNEVSG NFVEESPEKL LDNDPSFFNH FNLVVATQLP
     ESTLLRLAEL LWSSNVPLLV CRTYGLVGYM RVIIKEHTVV ESHPDNTLED LRLDKPFPEL
     REHIQSYDLD HMDKKDHSHT PWIVIVAKYL TKWFNEKSDQ LPKSYKEKEA FRQLIRQGIL
     KNENGTPEDE ENFEEAIKNV NTALNTTEIP RCIEEIFNDD CCINLTEQSP SFWILARAVK
     EFVANEGQGS LPVRGTIPDM IADSNKFIKL QNVYREKAKK DIAAVGNHAA KLLQSLGKAP
     ESISERELKL FCSNSAFLRV VRCRSLSEEY GLNTFNKDEI ISHMDNPDSE LVLYLMLRAV
     DRFYKQHGRY PGVYNYQVED DIGKLKSCLT GFLQEHGLSV VVKDDYVHEF CRYGAAEPHA
     IAAFMGGAAA QEVIKVITGQ FVIFNNTYIY SGMSQTSATF QL
//