ID A0A091WCI1_OPIHO Unreviewed; 430 AA.
AC A0A091WCI1;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Legumain {ECO:0000256|ARBA:ARBA00021147};
DE EC=3.4.22.34 {ECO:0000256|ARBA:ARBA00012628};
DE AltName: Full=Protease, cysteine 1 {ECO:0000256|ARBA:ARBA00030799};
DE Flags: Fragment;
GN ORFNames=N306_04579 {ECO:0000313|EMBL:KFR12503.1};
OS Opisthocomus hoazin (Hoatzin) (Phasianus hoazin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Opisthocomiformes; Opisthocomidae;
OC Opisthocomus.
OX NCBI_TaxID=30419 {ECO:0000313|EMBL:KFR12503.1, ECO:0000313|Proteomes:UP000053605};
RN [1] {ECO:0000313|EMBL:KFR12503.1, ECO:0000313|Proteomes:UP000053605}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N306 {ECO:0000313|EMBL:KFR12503.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of proteins and small molecule substrates at
CC -Asn-|-Xaa- bonds.; EC=3.4.22.34;
CC Evidence={ECO:0000256|ARBA:ARBA00000810};
CC -!- SIMILARITY: Belongs to the peptidase C13 family.
CC {ECO:0000256|ARBA:ARBA00009941}.
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DR EMBL; KK735116; KFR12503.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091WCI1; -.
DR STRING; 30419.A0A091WCI1; -.
DR MEROPS; C13.004; -.
DR PhylomeDB; A0A091WCI1; -.
DR Proteomes; UP000053605; Unassembled WGS sequence.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:UniProtKB-EC.
DR GO; GO:0051603; P:proteolysis involved in protein catabolic process; IEA:InterPro.
DR CDD; cd21115; legumain_C; 1.
DR Gene3D; 1.10.132.130; -; 1.
DR Gene3D; 3.40.50.1460; -; 1.
DR InterPro; IPR043577; AE.
DR InterPro; IPR048501; Legum_prodom.
DR InterPro; IPR046427; Legumain_prodom_sf.
DR InterPro; IPR001096; Peptidase_C13.
DR PANTHER; PTHR12000; HEMOGLOBINASE FAMILY MEMBER; 1.
DR PANTHER; PTHR12000:SF42; LEGUMAIN; 1.
DR Pfam; PF20985; Legum_prodom; 1.
DR Pfam; PF01650; Peptidase_C13; 1.
DR PIRSF; PIRSF500139; AE; 1.
DR PIRSF; PIRSF019663; Legumain; 1.
DR PRINTS; PR00776; HEMOGLOBNASE.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000053605};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..430
FT /note="Legumain"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001881085"
FT DOMAIN 333..428
FT /note="Legumain prodomain"
FT /evidence="ECO:0000259|Pfam:PF20985"
FT ACT_SITE 148
FT /evidence="ECO:0000256|PIRSR:PIRSR019663-1"
FT ACT_SITE 189
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR019663-1"
FT NON_TER 430
FT /evidence="ECO:0000313|EMBL:KFR12503.1"
SQ SEQUENCE 430 AA; 49027 MW; E0DF576B00005A3F CRC64;
MILKAVVLLG CALGISTFPR EEPEDGGKHW VVIVAGSNGW YNYRHQADVC HAYQIVHRNG
IPDEQIIVMM YDDIADNEEN PTKGVVINRP NGTDVYAGVP KDYTKEEVTP KNFLAVLRGD
VEAVKGVGSG KVLKSGPKDH VFVYFTDHGA PGLLAFPDDD LHVKDLNKTI WYMYRHKKYR
KMVFYIEACE SGSMMNHLAD SINVYATTAA NPRESSYACY YDDERQTYLG DWYSVNWMED
SDMEDLRKET LHKQFQLVKK RTNTSHVMQY GNRSISSMKV MQFQGLGKKA IPISLPPVEH
YDLTPSPDVP LAIMKRKLMA TNDIYEAKKI AAEIKIHLEV KEFIQESMRK IITLVTGSKE
QTNQILSDRL TISNYDCYQS AVNHFKARCF NWHLSVYEYA LRQLYALVNV CEGGYPIDRI
CLAMDQVCLG
//
