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Database: UniProt
Entry: A0A091X8F0_OPIHO
LinkDB: A0A091X8F0_OPIHO
Original site: A0A091X8F0_OPIHO 
ID   A0A091X8F0_OPIHO        Unreviewed;      4899 AA.
AC   A0A091X8F0;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   28-FEB-2018, entry version 22.
DE   SubName: Full=Ryanodine receptor 2 {ECO:0000313|EMBL:KFR09681.1};
DE   Flags: Fragment;
GN   ORFNames=N306_02740 {ECO:0000313|EMBL:KFR09681.1};
OS   Opisthocomus hoazin (Hoatzin) (Phasianus hoazin).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Opisthocomiformes; Opisthocomidae;
OC   Opisthocomus.
OX   NCBI_TaxID=30419 {ECO:0000313|EMBL:KFR09681.1, ECO:0000313|Proteomes:UP000053605};
RN   [1] {ECO:0000313|EMBL:KFR09681.1, ECO:0000313|Proteomes:UP000053605}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N306 {ECO:0000313|EMBL:KFR09681.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; KK734554; KFR09681.1; -; Genomic_DNA.
DR   PhylomeDB; A0A091X8F0; -.
DR   Proteomes; UP000053605; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000053605};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:KFR09681.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053605};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4212   4230       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4432   4452       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4506   4525       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4642   4663       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4700   4721       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4776   4799       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       55    110       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      117    162       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      170    225       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      231    288       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      296    353       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      556    754       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      970   1167       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1302   1507       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3955   3990       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      417    437       {ECO:0000256|SAM:Coils}.
FT   COILED     3002   3022       {ECO:0000256|SAM:Coils}.
FT   COILED     4347   4370       {ECO:0000256|SAM:Coils}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:KFR09681.1}.
FT   NON_TER    4899   4899       {ECO:0000313|EMBL:KFR09681.1}.
SQ   SEQUENCE   4899 AA;  557459 MW;  1966D1AF91770702 CRC64;
     NVPPDLSICT FVLEQSLSVR ALQEMLANTE EKAEGVRNFS MTLVFIFQSA QGGGHRTLLY
     GHAILLRHSY SGMYLCCLST SRSSMDKLAF DVGLQEDTTG EACWWTIHPA SKQRSEGEKV
     RVGDDLILVS VSSERYLHLS YGNGSLHVDA AFQQTLWSVA PISSGSEAAQ GYLIGGDVLR
     LLHGHMDECL TVPSGEHGEE QRRTVHYEGG AVSIHARSLW RLETLRVAWS GSHIRWGQPF
     RLRHITTGKY LSLLDDKSLL LTDKEKADVK STAFCFRSSK EKLDIGTRKE VDGMGAPEIK
     YGDSICFIQH VDTGLWLTYQ SADAKSVRMG SVQRKAIMHH EGHMDDGLTL SRSQNEESRT
     ARVIRSTVFL FNRFIRGLDA LSKKVKSSTV DLPIESVSLS LQDLIGYFHP PGENLEHEDK
     QNRLRALKNR QNLFQEEGMI NLVLECIDRL NVYSSAAHFA DVAGKEAGEA WKSILNSLYE
     LLAALIRGNR KNCAQFSGSL DWLISRLERL EASSGILEVL HCVLVESPEA LNIIKEGHIK
     SIICLLDKHG RNHKVLDVLC SLCVCHGVAV RSNQHLICDN LLPGRDLLLQ TRLVNHVSSM
     RPNIFLGISE GSAQYRKWYY ELMVDHLEPF VTAESTHLRV GWASTEGYSP YPGGGAEWGG
     NGVGDDLYSY GFDGLHLWSG CVARTVNSPN QHLLRTDDVI SCCLDLSAPS ISFRINGQPV
     QGMFENFNID GLFFPVVSFS AGIKVRFLLG GRHGEFKFLP PPGYAPCFEA VLPKEKLKVE
     HSREYKQDRS YTRDLLGPTI SLSQAAFTPV PVDTSQIVLP PHLERIREKL AENIHELWVM
     NKIELGWQYG PIRDDNKRQH PCLVEFSKLP EQERNYNLQM SLETLKTLLA LGCHVGIADE
     HAEEKVKKMK LPKNYQLLSG YKPAPMDLSF IKLTPSQEAM VDKLAENAHN VWARDRIRQG
     WTYGIQQDVK NRRNPRLVPY ALLDDRTKKS NKDSLREAVR TLLGYGYNLE APDQDHAMRL
     DVCSGIMEKF RIFRTEKTYA VKAGKWYFEF EAVTAGDMRV GWTRPGCLPD QELGSDEEAF
     VFDGFKAQRW HQGNEHFGRS WLAGDVVGCM VDMNEHTMMF TLNGEILLDD SGSELAFKDF
     EVGDGFLPVC SLGPSQVGRM NFGKDVSTLK YFTICGLQEG YEPFAVNTNR DITIWLSKRL
     PQFLPVPQNH EHIEVMRIDG TVDSCPCLKV TQKSFGSQNS KTDVMFFRLS MPIECAEVFS
     RSAAGGLPGS GLFGPKNDLE DYDADSDFEV LMKTAHGHLV PDRIEREKDA IKTELNNHKD
     YVQEKPSRLK QRFMLRRTKP DYSMSHSARL TEDVLADDRD DYDYLMQTST YYYSVRIFPG
     QEPANVWVGW ITSDFHQYDT SFDLDRVRTV TVTLGDEKGK VHESIKRSNC YMVCAGESMS
     PGQGRNNNGL EIGCLVDAAS GLLTFTANGK ELGTYYQVEP STKLFPAVFA QATSPNVFQF
     ELGRIKNVMP LSAGLFKSEH KNPVSQCPPR LHVQFLTHVL WSRVPNHFLK VDVSRVNERQ
     GWMIQCLNPL QFMALHIPEE NRTIDILELT EQEELLKFHY HTLRLYSAVC ALGNNRVAHA
     MCSHVDESQL LYAIENKYMP GLLRAGYYDL LIDIHLNTYA TARLMMNNEF IVPMTDETKS
     ITLFPDENKK HGLPGIGLST SLRPRMQFSS PSFVSISSEC FQFSPEFPLE ILKAKTIEML
     TEAVQEGSLH VRDPVGGSTE FLFVPLIKLF YTLLIMGIFH NGDLKHILQL IEPRVFKEAV
     SQEDDIDFSE KELSSDELKS EEGEEETRGE QVPKEGLLQM KLPEPVKLQM CHLLQYLCDC
     QVRHRIEAIV AFSDDFVAKL QENQRFRYNE VMQALNMSAA LTARKTKEFR SPPQEQINML
     LNFKDDKNDC PCPEEIQDQL LDFHEDLMTH CGIELDEDGS LDGNSDLTIR GRLLYLMEKV
     TYLKKKQAEK PIDDDAKTSS TLQQLISDTM VRWAQESVIE DPELVRAMFV LLHRQYDGIG
     GLVRALPKTY TINSVSVEDT INLLASLGQI RSLLSVRMGK EEEKLMIRGL GDIMNNKVFY
     QHPNLMRALG MHETVMEVMV NVLGGGESKE ITFPKMVANC CRFLCYFCRI SRQNQKAMFD
     HLSYLLENSS VGLASPSMRG STPLDVAAAS VMDNNELALA LREPDLEKVV RYLAGCGLQS
     CPLLICKGYP DIGWNPVEGE RYLDFLRFAV FCNGESVEEN ANVVVRLLIR RPECFGPALR
     GEGGNGLLAA MEEAIQISED PTRDGPSPSN GSSKTLEMEE QEDDTIHMGN AIMTFYAALI
     DLLGRCAPEM HLIHAGKGEA IRIRSILRSL IPLEDLVGVI SIPFHMPTIA KDGTVVEPDM
     SAGFCPDHKA AMVLFLDRVY GIEDQDFLLH LLEVGFLPDL RAAASLDTAA LSATDMALAL
     NRYLCTAVLP LLTRCAPLFA GTEHHASLID SLLHTVYRLS KGCSLTKAQR DSIEECLLSI
     CGQLRPSMMQ HLLRRLVFDV PLLNEHAKMP LKLLTNHYER CWKYYCLPGG WGNFGAASEE
     ELHLSRKLFW GIFDALSQKK YEQELFKLAL PCLSAVAGAL PPDYMESNYV NMMEKQASMD
     SDGNFNPQPV DTSNITIPEK LEYFINKYAE HSHDKWSMEK FANGWTYGET YSESAKVQPL
     MKQYKLLSEK EKEIYRWPIK ESLKTMLAWG WRIERTREGD SMALYNRTRR ISQTSQISVD
     TAHGYTPRAI DMSNVTLSRD LHAMAEMMAE NYHNIWAKKK KMELEAKGGG NHPLLVPYDT
     LTAKEKAKDR EKAQDILKFL QINGYVVSRG LKELELDTPS IEKRFAYSFL QQLIRYVDEA
     HQYILEFDGG SRGKGEHFPY EQEIKFFAKV VLPLIDQYFK NHRLYFLSAA SRPLSSGGHA
     SNKEKEMVTS LFCKLGVLVR HRISLFGNDA TSIVNCLHIL GQTLDARTVM KTGLESVKMA
     LRAFLDNAAE DLEKTMENLK QGQFTHSRNQ PKGVTQIINY TTVALLPVLS SLFEHIGQHQ
     FGEDLILEDV QVSCYRILAS LYALGTRKRF LQRSALGECL AAFSGAFPVA FLETHLNKHN
     VYSIYNTKNA RDRAVLNLPA SVEEVCSNIP SLVKLMEEIV ELAESGIRYT QMPHIMEVIL
     PMLCSYMSHW WEHGPENNPD KAEMCCTALT SEHMNTLLGN ILKIIYNNLG IDEGAWMKRL
     AVFSQPIISK AKPQLLKTHF LPLMDKLKKK AAVVVSDEEH LRAEGRGDMS EAELLILDEF
     TTLARDLYAF YPLLIRFVDY NRAKWLKEPN PEAEELFRMV AEVFIYWSKS HNFKREEQNF
     VVQNEINNMS FLISDTKSKM SKAAVSDQER KKMKRKGDRY SMQTSLIVAA LKRLLPIGLN
     ICAPGDQELI ALAKNRFSMK DTEDEVRDII RNNLHLQGKL EDPAIRWQMA LYKDLPNRSE
     DSSDPEKTVE RVLDIANVLF HLEQVRHVEH PQRSKKAVWH KLLSKQRKRA VVACFRMAPL
     YNLPRHRAVN LFLQGYDKSW IETEEHYFED KLIEDLAKPG EEPPEEDESL KRVDPLHQLI
     LLFSRTALTE KCKLDEDFLY MAYADIMAKS CHDEDDDDGE EEVKSFEEKE MEKQKLLYQQ
     ARLHDRGAAE MVLQTISASK GEMGPMVAAT LKLGIAILNG GNSTVQQKML DYLKDKKDVG
     FFQSLAGLMQ SCSVLDLNAF ERQNKAEGLG MVTEEGSGEK VMQDDEFTCD LFRFLQLLCE
     GHNSDFQNYL RTQTGNNTTV NIIISTVDYL LRVQESISDF YWYYSGKDVI DEQGQRNFSK
     AIQVAKQVFN TLTEYIQGPC TGNQQSLAHS RLWDAVVGFL HVFAHMQMKL SQDSSQIELL
     KELMDLQKDM VVMLLSMLEG NVVNGTIGKQ MVDMLVESSN NVEMILKFFD MFLKLKDLTS
     SDAFKEYDPD CKGIISKRDF HKAMESHKHY TQSETEFLLS CAETDENETL DYEEFVKRFH
     EPAKDIGFNV AVLLTNLSEH MPHDTRLQTF LELSESVLNY FQPFLGRIEI MGSAKRIERV
     YFEISESSRT QWEKPQVKES KRQFIFDVVN EGGEKEKMEL FVNFCEDTIF EMQLAAQISE
     SDLNERSANK EENEKYKPED QDPRMGFFSL MTMKSALVAL KYNLMTLMKM LSMKSLKKQM
     KKVKKMTMKD MVMALFSSYW SILMGLLHFA CSVVRGFFRI ICSLLLGGSL VEGAKKIKVA
     ELLANMPDPT QDEVRGEGEE GGERKPTEAA LPTEDLTDLR TLSDESDLLS DIFGLDLKRE
     GGQYKLIPHN PNAGLSDLLS TPSLAPMPEV QEKVQVKEDE KEEKEETKSE PEKADGEDGE
     KEEKAKEDKG KQKLRQIHTH RYGEPEVQES AFWKKIIAYQ QKLLNYFARN FYNMRMLALF
     VAFAINFILL FYKVSTSAVM EEKEVPVVSA GESTNLNSLE SDHQRVIAVH YVLEESSGYM
     EPTLRILAIL HTVISFFCII GYYCLKVPLV IFKREKEVAR KLEFDGLYIT EQPSEDDIKG
     QWDRLVINTQ SFPNNYWDKF VKRKVMDKYG EFYGRDRISE LLGMDKAALD FSDAREKKKP
     KKDSSLSAVL NSIDVKYQMW KLGVVFTDNS FLYLAWYMTM SVLGHYNNFF FAAHLLDIAM
     GFKTLRTILS SVTHNGKQLV LTVGLLAVVV YLYTVVAFNF FRKFYNKSED GDMPDMKCDD
     MLTCYMFHMY VGVRAGGGIG DEIEDPAGDE YEIYRIIFDI TFFFFVIVIL LAIIQGLIID
     AFGELRDQQE QVKEDMETKC FICGIGNDYF DTVPHGFETH TLQEHNLANY LFFLMYLINK
     DETEHTGQES YVWKMYQERC WEFFPAGDCF RKQYEDQLN
//
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